Bromadiolone poisoning: LC-MS method and pharmacokinetic data

Journal of Forensic Sciences

Volumn 53, Issue 4, 2008, Pages 993-996

  Vindenes, Vigdis ^a   Karinen, Ritva ^a   Hasvold, Inger ^a   Bernard, Jean Paul ^a   Mørland, Jørg G ^a   Christophersen, Asbjørg S ^a  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

Author keywords

Bromadiolone; Forensic science; Forensic toxicology; Liquid chromatography mass spectrometry; Poisoning; Superwarfarins

Indexed keywords

BROMADIOLONE;

ADULT; ARTICLE; BLOOD SAMPLING; CASE REPORT; DRUG ELIMINATION; FEMALE; FREEZE ETCHING; HALF LIFE TIME; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHODOLOGY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; THAWING;

4-HYDROXYCOUMARINS; ANTICOAGULANTS; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; FEMALE; FORENSIC TOXICOLOGY; HALF-LIFE; HUMANS; MASS SPECTROMETRY; MIDDLE AGED; MOLECULAR STRUCTURE;

EID: 47349108774     PISSN: 00221198     EISSN: 15564029     Source Type: Journal    
DOI: 10.1111/j.1556-4029.2008.00737.x     Document Type: Article

References (14)

1. Routh CR, Triplett DA, Murphy MJ, Felice LJ, Sadowski JA, Bovill EG. Superwarfarin ingestion and detection. Am J Hematol 1991 36 : 50 4.
2. Sharma P, Bentley P. Of rats and men: superwarfarin toxicity. Lancet 2005 365 : 552 3.
3. Chua JD, Friedenberg WR. Superwarfarin poisoning. Arch Intern Med 1998 158 : 1929 32.
4. Hui CH, Lie A, Lam CK, Bourke C. "Superwarfarin" poisoning leading to prolonged coagulopathy. Forensic Sci Int 1996 78 : 13 8.
5. Sarin S, Mukhtar H, Mirza MA. Prolonged coagulopathy related to superwarfarin overdose. Ann Intern Med 2005 142 : 56.
6. Kuijpers EA, den Hartigh J, Savelkoul TJ, de Wolff FA. A method for the simultaneous identification and quantitation of five superwarfarin rodenticides in human serum. J Anal Toxicol 1995 19 : 557 62.
7. Jin MC, Ren YP, Xu XM, Chen XH. Determination of bromadiolone in whole blood by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Forensic Sci Int 2007 171 : 52 6.
8. Grobosch T, Angelow B, Schonberg L, Lampe D. Acute bromadiolone intoxication. J Anal Toxicol 2006 30 : 281 6.
9. Lipton RA, Klass EM. Human ingestion of a "superwarfarin" rodenticide resulting in a prolonged anticoagulant effect. JAMA 1984 252 : 3004 5.
10. Rowland M, Tozer TN, editors. Clinical pharmacokinetics; concepts and applications, 3rd ed. Media, PA : Lippincott Williams & Wilkins, 1995.
11. Chow EY, Haley LP, Vickars LM, Murphy MJ. A case of bromadiolone (superwarfarin) ingestion. CMAJ 1992 147 : 60 2.
12. Pavlu J, Harrington DJ, Voong K, Savidge GF, Jan-Mohamed R, Kaczmarski R. Superwarfarin poisoning. Lancet 2005 365 : 628.
13. Smith-Kielland A, Skuterud B, Morland J. Urinary excretion of 11-nor-9-carboxy-delta9-tetrahydrocannabinol and cannabinoids in frequent and infrequent drug users. J Anal Toxicol 1999 23 : 323 32.
14. Hasler JA. Pharmacogenetics of cytochromes P450. Mol Aspects Med 1999 20 : 12 137.