'Superwarfarin' poisoning leading to prolonged coagulopathy

Forensic Science International

Volumn 78, Issue 1, 1996, Pages 13-18

  Hui, C H ^a,b   Lie, A ^a   Lam, C K ^a   Bourke, C ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b QUEEN MARY HOSPITAL   (Hong Kong)

Author keywords

Brodifacoum intoxication; Coagulopathy; Rodenticide poisoning; Superwarfarin

Indexed keywords

ANTICOAGULANT AGENT; BRODIFACOUM; FRESH FROZEN PLASMA; NON PRESCRIPTION DRUG; RODENTICIDE; VITAMIN K GROUP; WARFARIN;

AGED; ARTICLE; BLOOD CLOTTING DISORDER; BLOOD CLOTTING TIME; CASE REPORT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTOXICATION; INTRAVENOUS DRUG ADMINISTRATION; LIVER DISEASE; MALABSORPTION; MALE; PRIORITY JOURNAL;

EID: 0029993425     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/0379-0738(95)01835-2     Document Type: Article

References (15)

1. 1 metabolism and clotting factor activity in warfarin-susceptible and warfarin-resistant rats. Biochem. Pharmacol., 30 (1981) 123-128.
2. R.A. Lipton and E.M. Klass, Human ingestion of a 'superwarfarin' rodenticide resulting in a prolonged anticoagulant effect. J. Am. Med. Assoc., 252 (1984) 3004-3005.
3. E.C. Jones, G.H. Growe, and S.C. Naiman, Prolonged anticoagulation in rat poisoning. J. Am. Med. Assoc., 252 (1984) 3005-3007.
4. S.C. Smolinske, D.L. Scherger, P.S. Kearns, K.M. Wruk K.W. Kulig and B.H. Rumack, Superwarfarin poisoning in children: a prospective study. Pediatrics, 84 (1989) 490-494.
5. C.R. Routh, D.A. Triplett, M.J. Murphy, L.J. Felice J.A. Sadowski and E.G.T. Bovill, Superwarfarin ingestion and detection. Am. J. Hematol., 36 (1991) 50-54.
6. V.T. Barnett, F. Bergmann, H. Humphrey and J. Chediak Diffuse alveolar haemorrhage secondary to superwarfirin ingestion. Chest, 102 (1992) 1301-1302.
7. B.K. Park, I.A. Choonara, B.P. Haynes, A.M. Breckenridge, R.G. Malia and F.E. Preston, Abnormal vitamin K metabolism in the presence of normal clotting factor activity in factory workers exposed to 4-hydroxycoumanns. Br. J. Clin. Pharmacol., 21 (1986) 289-294.
8. L.J. Felice and M.J. Murphy, The determination of the anticoagulant rodenticide Brodifacoum in blood serum by liquid chromatography with fluorescence detection. J. Anal. Toxicol., 13 (1989) 229-231.
9. 1 in relation to anticoagulant poisoning. Br. J. Clin. Pharmacol., 18 (1984) 655-662.
10. R. Hollinger, T.P. Pastoor, Case management and plasma half-life in a case of brodifacoum poisoning. Arch. Intern. Med., 153 (1993) 1925-1928.
11. J.N. Weitzel, J.A. Sadowski, B.C. Furie, R. Moroose H. Kim, M.E. Mount, M.J. Murphy and B. Furie, Surreptitious ingestion of a long-acting vitamin K antiagonist/rodenticide Brodificoum: Clinical and metabolic studies of three cases. Blood, 76 (1990) 2555-2559.
12. R.G. Watts, R.P. Castleberry and J.A. Sadowski Accidental poisoning with a superwarfarin compound (Brodifacoum) in a child. Pediatrics, 86 (1990) 883-887.
13. K.A. Bachmann and T.J. Sullivan, Dispositional and pharmacodynamic characteristics of brodifacoum in warfarin-sensitive rats. Pharmacology, 27 (1983) 281-288.
14. R.A. O'Reilly and P.M. Aggeler, Covert anticoagulant ingestion: study of 25 patients and review of world literature. Medicine, 55 (1976) 389-399.
15. L.L. Chong, W.K. Chau and C.H. Ho, A case of 'superwarfarin' poisoning. Scand. J. Haematol., 36 (1986) 314-315.