메뉴 건너뛰기




Volumn 20, Issue 3, 2008, Pages 291-296

Treatment options in myelodysplastic syndromes: A new frontier

Author keywords

Epigenetic drugs; Growth factors; Immunosuppressive agents; Myelodysplastic syndromes; Tyrosine kinase inhibitors

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AMG 153; ANTINEOPLASTIC AGENT; AZACITIDINE; CYCLOSPORIN; CYTARABINE; DASATINIB; ETANERCEPT; GRANULOCYTE COLONY STIMULATING FACTOR; GROWTH FACTOR; HISTONE DEACETYLASE INHIBITOR; IMATINIB; IMMUNOMODULATING AGENT; IMMUNOSUPPRESSIVE AGENT; LENALIDOMIDE; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; RECOMBINANT ERYTHROPOIETIN; RETINOIC ACID; SODIUM PHENYLBUTYRATE; SUBERANOYL HYDROXAMIC ACID; THALIDOMIDE; THYMOCYTE ANTIBODY; VALPROIC ACID;

EID: 47349094477     PISSN: 1120009X     EISSN: None     Source Type: Journal    
DOI: 10.1179/joc.2008.20.3.291     Document Type: Review
Times cited : (3)

References (42)
  • 1
    • 32844460736 scopus 로고    scopus 로고
    • Molecular cytogenetic profiling of complex karyotypes in primary myelodysplastic syndromes and acute myeloid leukemia
    • Trost D, Hildebrandt B, Beier M, et al. Molecular cytogenetic profiling of complex karyotypes in primary myelodysplastic syndromes and acute myeloid leukemia. Cancer Genet Cytogenet 2006; 165, 1: 51-63.
    • (2006) Cancer Genet Cytogenet , vol.165 , Issue.1 , pp. 51-63
    • Trost, D.1    Hildebrandt, B.2    Beier, M.3
  • 2
    • 38049174262 scopus 로고    scopus 로고
    • Hematology Am Soc Hematol Educ Program
    • Look AT. Molecular Pathogenesis of MDS. Hematology Am Soc Hematol Educ Program 2005; 156-60.
    • (2005) Molecular Pathogenesis of MDS , pp. 156-160
    • Look, A.T.1
  • 3
    • 85036952913 scopus 로고    scopus 로고
    • Silverman L. Myelodysplastic syndromes.In: Kue DW, Weichselbaum RR, Bast RC, et al. (eds). Cancer Medicine, 6th ed Hamilton (Canada): BC Decker Inc, 2003.
    • Silverman L. Myelodysplastic syndromes.In: Kue DW, Weichselbaum RR, Bast RC, et al. (eds). Cancer Medicine, 6th ed Hamilton (Canada): BC Decker Inc, 2003.
  • 4
    • 33846515640 scopus 로고    scopus 로고
    • Myelodysplastic syndromes: The complexity of stem-cell diseases
    • Corey SJ, Minden MD, Barber DL, et al. Myelodysplastic syndromes: the complexity of stem-cell diseases. Nat Rev Cancer 2007; 7, 2: 118-29.
    • (2007) Nat Rev Cancer , vol.7 , Issue.2 , pp. 118-129
    • Corey, S.J.1    Minden, M.D.2    Barber, D.L.3
  • 5
    • 29244431621 scopus 로고    scopus 로고
    • The myelodysplastic syndromes: Diagnosis, molecular biology and risk assessment
    • Bennett JM and Komrokji RS. The myelodysplastic syndromes: diagnosis, molecular biology and risk assessment. Hematology 2005; 10, Suppl 1: 258-69.
    • (2005) Hematology , vol.10 , Issue.SUPPL. 1 , pp. 258-269
    • Bennett, J.M.1    Komrokji, R.S.2
  • 7
    • 33947710653 scopus 로고    scopus 로고
    • Hematopathological concepts and controversies in the diagnosis and classification of myelodysplastic syndromes
    • Vardiman JW. Hematopathological concepts and controversies in the diagnosis and classification of myelodysplastic syndromes. Hematology Am Soc Hematol Educ Program 2006; 199-204.
    • (2006) Hematology Am Soc Hematol Educ Program , pp. 199-204
    • Vardiman, J.W.1
  • 8
    • 0030897009 scopus 로고    scopus 로고
    • International scoring system for evaluating prognosis in myelodysplastic syndromes
    • Greenberg P, Cox C, LeBeau MM, et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 1997; 89, 6: 2079-88.
    • (1997) Blood , vol.89 , Issue.6 , pp. 2079-2088
    • Greenberg, P.1    Cox, C.2    LeBeau, M.M.3
  • 9
    • 32144431895 scopus 로고    scopus 로고
    • Prognostic factors and life expectancy in myelodysplastic syndromes classified according to WHO criteria: A basis for clinical decision making
    • Malcovati L, Porta MG, Pascutto C, et al. Prognostic factors and life expectancy in myelodysplastic syndromes classified according to WHO criteria: a basis for clinical decision making. J Clin Oncol 2005; 23, 30: 7594-603.
    • (2005) J Clin Oncol , vol.23 , Issue.30 , pp. 7594-7603
    • Malcovati, L.1    Porta, M.G.2    Pascutto, C.3
  • 10
    • 33745968917 scopus 로고    scopus 로고
    • Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia
    • Cheson BD, Greenberg PL, Bennett JM, et al. Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia. Blood 2006; 108, 2:419-25.
    • (2006) Blood , vol.108 , Issue.2 , pp. 419-425
    • Cheson, B.D.1    Greenberg, P.L.2    Bennett, J.M.3
  • 11
    • 33645057481 scopus 로고    scopus 로고
    • Myelodysplastic syndromes clinical practice guidelines in oncology
    • Greenberg PL, Baer MR, Bennett JM, et al. Myelodysplastic syndromes clinical practice guidelines in oncology. J Natl Compr Canc Netw 2006; 4, 1: 58-77.
    • (2006) J Natl Compr Canc Netw , vol.4 , Issue.1 , pp. 58-77
    • Greenberg, P.L.1    Baer, M.R.2    Bennett, J.M.3
  • 12
    • 0029933087 scopus 로고    scopus 로고
    • The effect of iron chelation on haemopoiesis in MDS patients with transfusional iron overload
    • Jensen PD, Heickendorff L, Pedersen B, et al. The effect of iron chelation on haemopoiesis in MDS patients with transfusional iron overload. Br J Haematol 1996; 94, 2: 288-99.
    • (1996) Br J Haematol , vol.94 , Issue.2 , pp. 288-299
    • Jensen, P.D.1    Heickendorff, L.2    Pedersen, B.3
  • 13
    • 33646414765 scopus 로고    scopus 로고
    • A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia
    • Cappellini MD, Cohen A, Piga A, et al. A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia. Blood 2006; 107, 9: 3455-62.
    • (2006) Blood , vol.107 , Issue.9 , pp. 3455-3462
    • Cappellini, M.D.1    Cohen, A.2    Piga, A.3
  • 14
    • 0032409909 scopus 로고    scopus 로고
    • A randomized double-blind placebo-controlled study with subcutaneous recombinant human erythropoietin in patients with low-risk myelodysplastic syndromes. Italian Cooperative Study Group for rHuEpo in Myelodysplastic Syndromes. Br J Haematol 1998; 103, 4: 1070-4
    • A randomized double-blind placebo-controlled study with subcutaneous recombinant human erythropoietin in patients with low-risk myelodysplastic syndromes. Italian Cooperative Study Group for rHuEpo in Myelodysplastic Syndromes. Br J Haematol 1998; 103, 4: 1070-4.
  • 15
    • 33646237362 scopus 로고    scopus 로고
    • High-dose darbepoetin alpha in the treatment of anaemia of lower risk myelodysplastic syndrome results of a phase II study
    • Mannone L, Gardin C, Quarre MC, et al. High-dose darbepoetin alpha in the treatment of anaemia of lower risk myelodysplastic syndrome results of a phase II study. Br J Haematol 2006; 133, 5: 513-9.
    • (2006) Br J Haematol , vol.133 , Issue.5 , pp. 513-519
    • Mannone, L.1    Gardin, C.2    Quarre, M.C.3
  • 16
    • 19944432966 scopus 로고    scopus 로고
    • Darbepoetin alpha for the treatment of anaemia in low-intermediate risk myelodysplastic syndromes
    • Musto P, Lanza F, Balleari E, et al. Darbepoetin alpha for the treatment of anaemia in low-intermediate risk myelodysplastic syndromes. Br J Haematol 2005; 128, 2: 204-9.
    • (2005) Br J Haematol , vol.128 , Issue.2 , pp. 204-209
    • Musto, P.1    Lanza, F.2    Balleari, E.3
  • 17
    • 28444489284 scopus 로고    scopus 로고
    • Darbepoetin alfa for the treatment of anemic patients with low- and intermediate-1-risk myelodysplastic syndromes
    • Stasi R, Abruzzese E, Lanzetta G, et al. Darbepoetin alfa for the treatment of anemic patients with low- and intermediate-1-risk myelodysplastic syndromes. Ann Oncol 2005; 16, 12: 1921-7.
    • (2005) Ann Oncol , vol.16 , Issue.12 , pp. 1921-1927
    • Stasi, R.1    Abruzzese, E.2    Lanzetta, G.3
  • 18
    • 0030695069 scopus 로고    scopus 로고
    • Antithymocyte globulin for patients with myelodysplastic syndrome
    • Molldrem JJ, Caples M, Mavroudis D, et al. Antithymocyte globulin for patients with myelodysplastic syndrome. Br J Haematol 1997; 99, 3:699-705.
    • (1997) Br J Haematol , vol.99 , Issue.3 , pp. 699-705
    • Molldrem, J.J.1    Caples, M.2    Mavroudis, D.3
  • 19
    • 0036720903 scopus 로고    scopus 로고
    • HLA-DR15 (DR2) is overrepresented in myelodysplastic syndrome and aplastic anemia and predicts a response to immunosuppression in myelodysplastic syndrome
    • Saunthararajah Y, Nakamura R, Nam JM, et al. HLA-DR15 (DR2) is overrepresented in myelodysplastic syndrome and aplastic anemia and predicts a response to immunosuppression in myelodysplastic syndrome. Blood 2002; 100, 5:1570-4.
    • (2002) Blood , vol.100 , Issue.5 , pp. 1570-1574
    • Saunthararajah, Y.1    Nakamura, R.2    Nam, J.M.3
  • 20
    • 34250767166 scopus 로고    scopus 로고
    • Low IPSS score and bone marrow hypocellularity in MDS patients predict hematological responses to antithymocyte globulin
    • Lim ZY, Killick S, Germing U, et al. Low IPSS score and bone marrow hypocellularity in MDS patients predict hematological responses to antithymocyte globulin. Leukemia 2007; 21, 7: 1436-41.
    • (2007) Leukemia , vol.21 , Issue.7 , pp. 1436-1441
    • Lim, Z.Y.1    Killick, S.2    Germing, U.3
  • 21
    • 0034903101 scopus 로고    scopus 로고
    • Searching for the magic bullet against cancer: The butyrate saga
    • Santini V, Gozzini A, Scappini B, et al. Searching for the magic bullet against cancer: the butyrate saga. Leuk Lymphoma 2001; 42, 3:275-89.
    • (2001) Leuk Lymphoma , vol.42 , Issue.3 , pp. 275-289
    • Santini, V.1    Gozzini, A.2    Scappini, B.3
  • 22
    • 0036554808 scopus 로고    scopus 로고
    • Impact of prolonged infusions of the putative differentiating agent sodium phenylbutyrate on myelodysplastic syndromes and acute myeloid leukemia
    • Gore SD, Weng LJ, Figg WD, et al. Impact of prolonged infusions of the putative differentiating agent sodium phenylbutyrate on myelodysplastic syndromes and acute myeloid leukemia. Clin Cancer Res 2002; 8, 4: 963-70.
    • (2002) Clin Cancer Res , vol.8 , Issue.4 , pp. 963-970
    • Gore, S.D.1    Weng, L.J.2    Figg, W.D.3
  • 23
    • 29144481615 scopus 로고    scopus 로고
    • Results of a phase 2 study of valproic acid alone or in combination with all-trans retinoic acid in 75 patients with myelodysplastic syndrome and relapsed or refractory acute myeloid leukemia
    • Kuendgen A, Knipp S, Fox F, et al. Results of a phase 2 study of valproic acid alone or in combination with all-trans retinoic acid in 75 patients with myelodysplastic syndrome and relapsed or refractory acute myeloid leukemia. Ann Hematol 2005; 84 Suppl 13: 61-6.
    • (2005) Ann Hematol , vol.84 , Issue.SUPPL. 13 , pp. 61-66
    • Kuendgen, A.1    Knipp, S.2    Fox, F.3
  • 24
    • 0027154222 scopus 로고
    • Effects of treatment with 5-azacytidine on the in vivo and in vitro hematopoiesis in patients with myelodysplastic syndromes
    • Silverman LR, Holland JF, Weinberg RS, et al. Effects of treatment with 5-azacytidine on the in vivo and in vitro hematopoiesis in patients with myelodysplastic syndromes. Leukemia 1993; 7 Suppl 1: 21-9.
    • (1993) Leukemia , vol.7 , Issue.SUPPL. 1 , pp. 21-29
    • Silverman, L.R.1    Holland, J.F.2    Weinberg, R.S.3
  • 25
    • 33748474416 scopus 로고    scopus 로고
    • Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: Studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B
    • Silverman LR, McKenzie DR, Peterson BL, et al. Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B. J Clin Oncol 2006; 24, 24: 3895-903.
    • (2006) J Clin Oncol , vol.24 , Issue.24 , pp. 3895-3903
    • Silverman, L.R.1    McKenzie, D.R.2    Peterson, B.L.3
  • 27
    • 31344446955 scopus 로고    scopus 로고
    • Combination therapy with DNA methyltrans-ferase inhibitors in hematologic malignancies
    • Gore SD. Combination therapy with DNA methyltrans-ferase inhibitors in hematologic malignancies. Nat Clin Pract Oncol 2005; 2, Suppl 1: S30-5.
    • (2005) Nat Clin Pract Oncol , vol.2 , Issue.SUPPL. 1
    • Gore, S.D.1
  • 28
    • 33646051586 scopus 로고    scopus 로고
    • Superiority of prolonged low-dose azanucleoside administration? Results of 5-aza-2′-deoxycytidine retreatment in high-risk myelodysplasia patients
    • Ruter B, Wijermans PW and Lubbert M. Superiority of prolonged low-dose azanucleoside administration? Results of 5-aza-2′-deoxycytidine retreatment in high-risk myelodysplasia patients. Cancer 2006; 106, 8: 1744-50.
    • (2006) Cancer , vol.106 , Issue.8 , pp. 1744-1750
    • Ruter, B.1    Wijermans, P.W.2    Lubbert, M.3
  • 29
    • 29144473297 scopus 로고    scopus 로고
    • An epigenetic approach to the treatment of advanced MDS; the experience with the DNA demethylating agent 5-aza-2′-deoxycytidine (decitabine) in 177 patients
    • Wijermans PW, Lubbert M, Verhoef G, et al. An epigenetic approach to the treatment of advanced MDS; the experience with the DNA demethylating agent 5-aza-2′-deoxycytidine (decitabine) in 177 patients. Ann Hematol 2005; 84, Suppl 13: 9-17.
    • (2005) Ann Hematol , vol.84 , Issue.SUPPL. 13 , pp. 9-17
    • Wijermans, P.W.1    Lubbert, M.2    Verhoef, G.3
  • 30
    • 33846011361 scopus 로고    scopus 로고
    • Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia
    • Kantarjian H, Oki Y, Garcia-Manero G, et al. Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia. Blood 2007; 109, 1: 52-7.
    • (2007) Blood , vol.109 , Issue.1 , pp. 52-57
    • Kantarjian, H.1    Oki, Y.2    Garcia-Manero, G.3
  • 31
    • 33646071894 scopus 로고    scopus 로고
    • Decitabine improves patient outcomes in myelodysplastic syndromes: Results of a phase III randomized study
    • Kantarjian H, Issa JP, Rosenfeld CS, et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer 2006; 106, 8: 1794-803.
    • (2006) Cancer , vol.106 , Issue.8 , pp. 1794-1803
    • Kantarjian, H.1    Issa, J.P.2    Rosenfeld, C.S.3
  • 32
    • 33750530675 scopus 로고    scopus 로고
    • Phase 1/2 study of the combination of 5-aza-2-deoxycytidine with valproic acid in patients with leukemia
    • Garcia-Manero G, Kantarjian HM, Sanchez-Gonzalez B, et al. Phase 1/2 study of the combination of 5-aza-2-deoxycytidine with valproic acid in patients with leukemia. Blood 2006; 108, 10: 3271-9.
    • (2006) Blood , vol.108 , Issue.10 , pp. 3271-3279
    • Garcia-Manero, G.1    Kantarjian, H.M.2    Sanchez-Gonzalez, B.3
  • 33
    • 34548529948 scopus 로고    scopus 로고
    • Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia
    • Blum W, Klisovic RB, Hackanson B, et al. Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia. J Clin Oncol. 2007; 25: 3884-91.
    • (2007) J Clin Oncol , vol.25 , pp. 3884-3891
    • Blum, W.1    Klisovic, R.B.2    Hackanson, B.3
  • 34
    • 13444256401 scopus 로고    scopus 로고
    • Efficacy of lenalidomide in myelodysplastic syndromes
    • List A, Kurtin S, Roe DJ, et al. Efficacy of lenalidomide in myelodysplastic syndromes. N Engl J Med 2005; 352, 6: 549-57.
    • (2005) N Engl J Med , vol.352 , Issue.6 , pp. 549-557
    • List, A.1    Kurtin, S.2    Roe, D.J.3
  • 35
    • 33749438404 scopus 로고    scopus 로고
    • Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion
    • List A, Dewald G, Bennett J, et al. Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. N Engl J Med 2006; 355, 14: 1456-65.
    • (2006) N Engl J Med , vol.355 , Issue.14 , pp. 1456-1465
    • List, A.1    Dewald, G.2    Bennett, J.3
  • 36
    • 27144551665 scopus 로고    scopus 로고
    • The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRbeta and FIPlLl-PDGFRalpha in vitro and in vivo
    • Stover EH, Chen J, Lee BH, et al. The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRbeta and FIPlLl-PDGFRalpha in vitro and in vivo. Blood 2005; 106, 9: 3206-13.
    • (2005) Blood , vol.106 , Issue.9 , pp. 3206-3213
    • Stover, E.H.1    Chen, J.2    Lee, B.H.3
  • 37
    • 33750299561 scopus 로고    scopus 로고
    • The JAK2 V617F mutation is rare in RARS but common in RARS-T
    • Ceesay MM, Lea NC, Ingram W, et al. The JAK2 V617F mutation is rare in RARS but common in RARS-T. Leukemia 2006; 20, 11: 2060-1.
    • (2006) Leukemia , vol.20 , Issue.11 , pp. 2060-2061
    • Ceesay, M.M.1    Lea, N.C.2    Ingram, W.3
  • 38
    • 3142580475 scopus 로고    scopus 로고
    • A decision analysis of allogeneic bone marrow transplantation for the myelodysplastic syndromes: Delayed transplantation for low-risk myelodysplasia is associated with improved outcome
    • Cutler CS, Lee SJ, Greenberg P, et al A decision analysis of allogeneic bone marrow transplantation for the myelodysplastic syndromes: delayed transplantation for low-risk myelodysplasia is associated with improved outcome. Blood. 2004; 104(2): 579-85.
    • (2004) Blood , vol.104 , Issue.2 , pp. 579-585
    • Cutler, C.S.1    Lee, S.J.2    Greenberg, P.3
  • 39
    • 34249786233 scopus 로고    scopus 로고
    • Valent P, Horny HP, Bennett JM, et al Definitions and standards in the diagnosis and treatment of the myelodysplastic syndromes: Consensus statements and report from a working conference. Leuk Res. 2007; 31(6): 727-36.
    • Valent P, Horny HP, Bennett JM, et al Definitions and standards in the diagnosis and treatment of the myelodysplastic syndromes: Consensus statements and report from a working conference. Leuk Res. 2007; 31(6): 727-36.
  • 40
    • 35349014739 scopus 로고    scopus 로고
    • Autologous stem cell transplantation in myelodysplastic syndromes.Semin
    • de Witte T, Suciu S, Brand R, et al. Autologous stem cell transplantation in myelodysplastic syndromes.Semin Hematol. 2007; 44(4): 274-7.
    • (2007) Hematol , vol.44 , Issue.4 , pp. 274-277
    • de Witte, T.1    Suciu, S.2    Brand, R.3
  • 41
    • 34548136106 scopus 로고    scopus 로고
    • A retrospective comparison of autologous and unrelated donor hematopoietic cell transplantation in myelodysplastic syndrome and secondary acute myeloid leukemia: A report on behalf of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)
    • Al-Ali HK, Brand R, van Biezen A, et al. A retrospective comparison of autologous and unrelated donor hematopoietic cell transplantation in myelodysplastic syndrome and secondary acute myeloid leukemia: a report on behalf of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT). Leukemia. 2007; 21(9): 1945-51.
    • (2007) Leukemia , vol.21 , Issue.9 , pp. 1945-1951
    • Al-Ali, H.K.1    Brand, R.2    van Biezen, A.3
  • 42
    • 33846222884 scopus 로고    scopus 로고
    • Autologous and allogeneic stem cell transplantation for myelodysplastic syndrome
    • de Witte T, Oosterveld M, Muus P. Autologous and allogeneic stem cell transplantation for myelodysplastic syndrome. Blood Rev. 2007; 21(1): 49-59.
    • (2007) Blood Rev , vol.21 , Issue.1 , pp. 49-59
    • de Witte, T.1    Oosterveld, M.2    Muus, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.