Methylation of class II transactivator gene promoter IV is not associated with susceptibility to Multiple Sclerosis

BMC Medical Genetics

Volumn 9, Issue , 2008, Pages

  Ramagopalan, Sreeram V ^a,b   Dyment, David A ^a,b   Morrison, Katie M ^a,b   Herrera, Blanca M ^a,b   DeLuca, Gabriele C ^a,b   Lincoln, Matthew R ^a,b   Orton, Sarah M ^a,b   Handunnetthi, Lahiru ^a,b   Chao, Michael J ^a,b   Sadovnick, A Dessa ^c   Ebers, George C ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TRANSACTIVATOR PROTEIN;

ADULT; ARTICLE; CLINICAL ARTICLE; DNA DETERMINATION; DNA METHYLATION; DNA MODIFICATION; DNA SEQUENCE; EPIGENETICS; FEMALE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; MALE; MONOZYGOTIC TWINS; MULTIPLE SCLEROSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PROMOTER REGION; CPG ISLAND; GENE; GENETIC PREDISPOSITION; GENETICS; METABOLISM; TWINS;

ADULT; CPG ISLANDS; DISEASES IN TWINS; DNA METHYLATION; FEMALE; GENES, MHC CLASS II; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MULTIPLE SCLEROSIS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); SEQUENCE ANALYSIS, DNA; TRANS-ACTIVATORS; TWINS, MONOZYGOTIC;

EID: 47249122586     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-9-63     Document Type: Article

References (24)

1. Dyment DA Ebers GC Sadovnick AD Genetics of multiple sclerosis Lancet Neurol 2004, 3(2):104-110. 10.1016/S1474-4422(03)00663-X 14747002
2. Zhang Z Duvefelt K Svensson F Masterman T Jonasdottir G Salter H Emahazion T Hellgren D Falk G Olsson T Hillert J Anvret M Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis Genes Immun 2005, 6(2):145-152. 10.1038/sj.gene.6364171 15674389
3. Hafler DA Compston A Sawcer S Lander ES Daly MJ De Jager PL de Bakker PI Gabriel SB Mirel DB Ivinson AJ Pericak-Vance MA Gregory SG Rioux JD McCauley JL Haines JL Barcellos LF Cree B Oksenberg JR Hauser SL Risk alleles for multiple sclerosis identified by a genomewide study N Engl J Med 2007, 357(9):851-862. 10.1056/NEJMoa073493 17660530
4. Peltonen L Old Suspects Found Guilty - The First Genome Profile of Multiple Sclerosis N Engl J Med 2007. 17660531
5. Fogdell A Hillert J Sachs C Olerup O The multiple sclerosis- and narcolepsy-associated HLA class II haplotype includes the DRB5*0101 allele Tissue Antigens 1995, 46(4):333-336. 8560455
6. Lincoln MR Montpetit A Cader MZ Saarela J Dyment DA Tiislar M Ferretti V Tienari PJ Sadovnick AD Peltonen L Ebers GC Hudson TJ A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis Nat Genet 2005, 37(10):1108-1112. 10.1038/ng1647 16186814
7. Chao MJ Barnardo MC Bu GZ Lincoln MR Ramagopalan SV Herrera BM Dyment DA Sadovnick AD Ebers GC Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: Accounting for linkage disequilibrium Hum Mol Genet 2007. 17584771
8. Dyment DA Herrera BM Cader MZ Willer CJ Lincoln MR Sadovnick AD Risch N Ebers GC Complex interactions among MHC haplotypes in multiple sclerosis: Susceptibility and resistance Hum Mol Genet 2005, 14(14):2019-2026. 10.1093/hmg/ddi206 15930013
9. Ramagopalan SV Morris AP Dyment DA Herrera BM Deluca GC Lincoln MR Orton SM Chao MJ Sadovnick AD Ebers GC The Inheritance of Resistance Alleles in Multiple Sclerosis PLoS Genet 2007, 3(9):e150. 10.1371/ journal.pgen.0030150
10. Ting JP Trowsdale J Genetic control of MHC class II expression Cell 2002, 109 (Suppl):S21-33. 10.1016/S0092-8674(02)00696-7 11983150
11. Reith W LeibundGut-Landmann S Waldburger JM Regulation of MHC class II gene expression by the class II transactivator Nat Rev Immunol 2005, 5(10):793-806. 10.1038/nri1708 16200082
12. Morris AC Spangler WE Boss JM Methylation of class II trans-activator promoter IV: A novel mechanism of MHC class II gene control J Immunol 2000, 164(8):4143-4149. 10754309
13. Swanberg M Lidman O Padyukov L Eriksson P Akesson E Jagodic M Lobell A Khademi M Borjesson O Lindgren CM Lundman P Brookes AJ Kere J Luthman H Alfredsson L Hillert J Klareskog L Hamsten A Piehl F Olsson T MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction Nat Genet 2005, 37(5):486-494. 10.1038/ng1544 15821736
14. Akkad DA Jagiello P Szyld P Goedde R Wieczorek S Gross WL Epplen JT Promoter polymorphism rs3087456 in the MHC class II transactivator gene is not associated with susceptibility for selected autoimmune diseases in German patient groups Int J Immunogenet 2006, 33(1):59-61. 10.1111/ j.1744-313X.2006.00568.x 16426246
15. Sadovnick AD Risch NJ Ebers GC Canadian collaborative project on genetic susceptibility to MS, phase 2: Rationale and method. Canadian Collaborative Study Group Can J Neurol Sci 1998, 25(3):216-221. 9706723
16. Ramagopalan SV Dyment DA Valdar W Herrera BM Criscuoli M Yee IM Sadovnick AD Ebers GC Autoimmune disease in families with multiple sclerosis: A population-based study Lancet Neurol 2007, 6(7):604-610. 10.1016/S1474-4422(07)70132-1 17560172
17. Bock C Walter J Paulsen M Lengauer T CpG island mapping by epigenome prediction PLoS Comput Biol 2007, 3(6):e110. 1892605 17559301 10.1371/ journal.pcbi.0030110
18. Sambrook J Russell DW Molecular cloning: A laboratory manual Cold Spring Harbor, New York, Cold Spring Harbor Laboratory Press 3rd 2001.
19. Herman JG Graff JR Myohanen S Nelkin BD Baylin SB Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands Proc Natl Acad Sci U S A 1996, 93(18):9821-9826. 38513 8790415 10.1073/ pnas.93.18.9821
20. Bird AP CpG-rich islands and the function of DNA methylation Nature 1986, 321(6067):209-213. 10.1038/321209a0 2423876
21. Willer CJ Dyment DA Risch NJ Sadovnick AD Ebers GC Twin concordance and sibling recurrence rates in multiple sclerosis Proc Natl Acad Sci U S A 2003, 100(22):12877-12882. 240712 14569025 10.1073/pnas.1932604100
22. Fraga MF Ballestar E Paz MF Ropero S Setien F Ballestar ML Heine-Suner D Cigudosa JC Urioste M Benitez J Boix-Chornet M Sanchez-Aguilera A Ling C Carlsson E Poulsen P Vaag A Stephan Z Spector TD Wu YZ Plass C Esteller M Epigenetic differences arise during the lifetime of monozygotic twins Proc Natl Acad Sci U S A 2005, 102(30):10604-10609. 1174919 16009939 10.1073/pnas.0500398102
23. Willer CJ Dyment DA Sadovnick AD Rothwell PM Murray TJ Ebers GC Timing of birth and risk of multiple sclerosis: Population based study Bmj 2005, 330(7483):120. 544426 15585537 10.1136/bmj.38301.686030.63
24. Dean G Elian M Age at immigration to England of Asian and Caribbean immigrants and the risk of developing multiple sclerosis J Neurol Neurosurg Psychiatry 1997, 63(5):565-568. 2169801 9408093