Formation of Fmoc-β-alanine during Fmoc-protections with Fmoc-OSu

Journal of Peptide Science

Volumn 14, Issue 6, 2008, Pages 763-766

  Obkircher, Markus ^a   Stähelin, Christian ^a   Dick, Fritz ^a  

^a Bachem Holding AG   (Switzerland)

Author keywords

Amino acid derivative; Fmoc Alanine impurity; Fmoc OSu; Lossen rearrangement; Peptide synthesis

Indexed keywords

9 FLUORENYLMETHYLSUCCINIMIDYLCARBONATE; 9H FLUOREN 9 YLMETHOXYCARBONYL BETA ALANINE; 9H FLUOREN 9 YLMETHOXYCARBONYL BETA ALANYLHYDROXIDE; ALPHA METHYLVALYLHYDROXIDE; AMINO ACID DERIVATIVE; BETA ALANINE; REAGENT;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; COUNTERCURRENT EXTRACTION; ELIMINATION REACTION; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN ISOLATION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; REACTION ANALYSIS; SEQUENCE ANALYSIS;

ALANINE; FLUORESCEINS; MASS SPECTROMETRY;

EID: 47249117200     PISSN: 10752617     EISSN: 10991387     Source Type: Journal    
DOI: 10.1002/psc.1001     Document Type: Article

References (4)

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3. Atherton E, Wellings DA. Preparation of 9-Fluorenylmethoxycarbonyl amino acids. In Houben-Weyl, Synthesis of Peptides and Peptidomimetics, Workbench Edition E22a. Goodman M (ed.). Georg Thieme Verlag: Stuttgart, 2004; 742.
4. Isidro-Llobet A, Just-Baringo X, Ewenson A, Álvarez M, Albericio F. Fmoc-2-Mercaptobenzothiazole, for the introduction of the Fmoc moiety free of side-reactions. Biopolymers (Pept. Sci.) 2007; 88: 733-737.