Paget cells in the esophagus: Assessment of their histopathologic features and near-universal association with underlying esophageal adenocarcinoma

American Journal of Surgical Pathology

Volumn 32, Issue 7, 2008, Pages 1068-1074

  Abraham, Susan C ^a   Wang, Huamin ^a   Wang, Kenneth K ^b   Wu, Tsung Teh ^b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Adenocarcinoma; E cadherin; Esophagus; Extramammary; Paget

Indexed keywords

AMYLASE; PROTEIN P53; UVOMORULIN; TUMOR MARKER;

ADULT; AGED; ARTICLE; BARRETT ESOPHAGUS; CLINICAL ASSESSMENT; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOSCOPIC BIOPSY; ENDOSCOPIC MUCOSAL RESECTION; ESOPHAGEAL ADENOCARCINOMA; ESOPHAGEAL PAGET DISEASE; ESOPHAGUS DISEASE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LOWER ESOPHAGUS SPHINCTER; MAJOR CLINICAL STUDY; MALE; PREVALENCE; SQUAMOUS EPITHELIUM; ADENOCARCINOMA; ESOPHAGUS; ESOPHAGUS TUMOR; GASTROINTESTINAL ENDOSCOPY; METABOLISM; MIDDLE AGED; PAGET SKIN DISEASE; PATHOLOGY;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; BARRETT ESOPHAGUS; ENDOSCOPY, GASTROINTESTINAL; ESOPHAGEAL NEOPLASMS; ESOPHAGUS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PAGET'S DISEASE, EXTRAMAMMARY; TUMOR MARKERS, BIOLOGICAL;

EID: 47249117048     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e318160c579     Document Type: Article

References (28)

1. Chan AO. E-cadherin in gastric cancer. World J Gastroenterol. 2006;12:199-203.
2. Chen CY, Sun LM, Anderson BO. Paget disease of the breast: changing patterns of incidence, clinical presentation, and treatment in the U.S. Cancer. 2006;107:1448-1458.
3. Chu P, Stagias J, West AB, et al. Diffuse pagetoid squamous cell carcinoma in situ of the esophagus: a case report. Cancer. 1997;79: 1865-1870.
4. Costello TJ, Wang HH, Schnitt SJ, et al. Paget's disease with extensive involvement of the female genital tract initially detected by cervical cytosmear. Arch Pathol Lab Med. 1988;112:941-944.
5. Flucke U, Steinborn E, Dries V, et al. Immunoreactivity of cytokeratins (CK7, CK20) and mucin peptide core antigens (MUC1, MUC2, MUC5AC) in adenocarcinomas, normal and metaplastic tissues of the distal oesophagus, oesophago-gastric junction and proximal stomach. Histopathology. 2003;43:127-134.
6. Goldblum JR, Hart WR. Perianal Paget's disease: a histologic and immunohistochemical study of 11 cases with and without associated rectal adenocarcinoma. Am J Surg Pathol. 1998;22:170-179.
7. Guo L, Kuroda N, Miyazaki E, et al. Anal canal neuroendocrine carcinoma with Pagetoid extension. Pathol Int. 2004;54:630-635.
8. Haleem A, Kfoury H, Al Juboury M, et al. Paget's disease of the oesophagus associated with mucous gland carcinoma of the lower oesophagus. Histopathology. 2003;42:61-65.
9. Harada O, Ota H, Katsuyama T, et al. Esophageal gland duct adenoma: immunohistochemical comparison with the normal esophageal gland and ultrastructural analysis. Am J Surg Pathol. 2007;31:469-475.
10. Higashiyama M, Doi O, Kodama K, et al. Extramammary Paget's disease of the bronchial epithelium. Arch Pathol Lab Med. 1991;115:185-188.
11. Ishihara A, Mori T, Koono M. Diffuse pagetoid squamous cell carcinoma of the esophagus combined with choriocarcinoma and mucoepidermoid carcinoma: an autopsy case report. Pathol Int. 2002;52:147-152.
12. Kanitakis J. Mammary and extramammary Paget's disease. J Eur Acad Dermatol Venereol. 2007;21:581-590.
13. Karakok M, Aydin A, Sari I, et al. Paget's disease of the esophagus. Dis Esophagus. 2002;15:334-335.
14. Kume K, Abe S, Okubo Y, et al. Superficial spreading carcinoma involving the whole esophagus. Dig Dis Sci.2001;46:776-778.
15. Liegl B, Leibl S, Gogg-Kamerer M, et al. Mammary and extramammary Paget's disease: an immunohistochemical study of 83 cases. Histopathology. 2007;50:439-447.
16. Lloyd J, Flanagan AM. Mammary and extramammary Paget's disease. J Clin Pathol. 2000;53:742-749.
17. Matsukuma S, Aida S, Shima S, et al. Paget's disease of the esophagus. A case report with review of the literature. Am J Surg Pathol. 1995;19:948-955.
18. Nair KS, Naidoo R, Chetty R. Expression of cell adhesion molecules in oesophageal carcinoma and its prognostic value. J Clin Pathol. 2005;58:343-351.
19. Nicoletti G, Scevola S, Ruggeriero R, et al. Gigantic Paget disease of the breast. Breast. 2004;13:425-427.
20. Nonomura A, Kimura A, Mizukami Y, et al. Paget's disease of the esophagus. J Clin Gastroenterol. 1993;16:130-135.
21. Norihisa Y, Kakudo K, Tsutsumi Y, et al. Paget's extension of esophageal carcinoma. Immunohistochemical and mucin histochem-ical evidence of Paget's cells in the esophageal mucosa. Acta Pathol Jpn. 1988;38:651-658.
22. Paget J. On disease of the mammary areola preceding cancer of the mammary gland. St Bartholemew Hosp Res London. 1874;10:87-89.
23. Regauer S. Extramammary Paget's disease - a proliferation of adnexal origin? Histopathology. 2006;48:723-729.
24. Suarez Vilela D, Izquierdo García F, Alonso Orcajo N. Squamous carcinoma of the esophagus with extensive pagetoid dissemination. Gastroenterol Hepatol. 1997;20:360-362.
25. Suenaga M, Oya M, Ueno M, et al. Anal canal carcinoma with Pagetoid spread: report of a case. Surg Today. 2006;36:666-669.
26. Theaker JM. Extramammary Paget's disease of the oral mucosa with in situ carcinoma of minor salivary glands. Am J Surg Pathol. 1988;12:890-895.
27. Tulchinsky H, Zmora O, Brazowski E, et al. Extramammary Paget's disease of the perianal region. Colorectal Dis. 2004;6:206-209.
28. Yates DR, Koss LG. Paget's disease of the esophageal epithelium. Report of first case. Arch Pathol. 1968;86:447-452.