Hepatoprotective effect of Andrographis paniculata against cadmium induced toxicity in male Wistar rats

Toxicology International

Volumn 15, Issue 1, 2008, Pages 21-25

  Prabu, S Milton ^a   Selvarajan, N ^a   Hemalatha, S ^a   Rameshkumar, T ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Andrographis paniculata; Antioxidant; Cadmium chloride; Rats

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANDROGRAPHIS PANICULATA EXTRACT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CADMIUM CHLORIDE; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LACTATE DEHYDROGENASE; LIPID; MALONALDEHYDE; SUPEROXIDE DISMUTASE;

ANDROGRAPHIS PANICULATA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CADMIUM POISONING; CONTROLLED STUDY; ENZYME ACTIVITY; LIPID PEROXIDATION; LIVER PARENCHYMA; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; TRADITIONAL MEDICINE; TREATMENT OUTCOME;

ANDROGRAPHIS PANICULATA; RATTUS; RATTUS NORVEGICUS;

EID: 47249090509     PISSN: 09716580     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. ATSDR (1993): Agency for Toxic Substances and Disease Registry. Toxicology profile for cadmium. Prepared under contract No. 205-88.0606 for: US Department of Health and Human Services. Public Health Service. Atlanda. G.A: ATSDR.
2. Choudhri BR and Poddar, MK. (1994): Andrographolide and Andrographis paniculata extracts: In vivo and invitro effect on hepatic lipid peroxidation. Fund. Exp. Clin. Pharmacol., 6: 481-484.
3. Dudley, RE, Svoboda, DJ and Klaassen, CD, (1982): Acute exposure to cadmium causes severe liver injury in rats. Toxicol. Appl. Pharmacol., 65: 302-313.
4. Flora, SJ, Gubrelay, V. Kannan, GM and Mathur. R. (1998). Effects of zinc supplementation during chelating agents administration in cadmium intoxication in rats. J. Appl. Toxicol., 18: 357-362.
5. Handa, SS and Sharma, A (1990): Hepatoprotective effect of andrographolide from Andrographis paniculata against CCl4. Indian J. Med. Res., 92: 276-278.
6. Isselbacher, KJ, (1994): Bilirubin metabolism and hyperbilirubinemia. In: Harrison's Principles of Internal Medicine. 13th Edition, pp. 165-167.
7. Jayaprakash, K and P. Chinnaswamy, (2005): Effect of Spirulina and Liv-52 on cadmium induced toxicity in albino rats. Indian J. Exp. Biol., 43: 773-781.
8. Kakkar P, B Das and Visvanathan, PN, (1984): A modified spectrophotometric assay of superoxide dismutase. Indian J. Biochem. Biophys., 211: 131-132.
9. Khandelwal, S., Shukla, LJ, Shankar R, (2002): Modulation of acute cadmium toxicity by Emblica officinalis fruit in rat. Indian. J. Exp. Biol., 40: 564-570.
10. Lowry OH, NJ Rosebrough, AL Farr and Randall, RJ, (1951): Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193: 163.
11. Manca, D. Richard, AC. Troltier, B and Cheralier G, (1971): Studies on lipid peroxidation in rat tissue following administration of low and moderate doses of cadmium chloride. Toxicology, 67: 303.
12. Mita Das, N Ghosh, D Chattopadhyay, S Addya and Chatterjee, GC, (1998): Effects of acute oral administration of cadmium chloride on uptake of element and control of lipoperoxidative process in hepatic and renal nuclear fractions of rats. Indian. J. Exp. Biol., 26: 449-452.
13. Moron, MS, JW Deflere and Mannervik, B, (1979): Levels of glutathione, glutathione reductase and glutathione-s-transferase activities in rat hung and liver. Biochem. Biophys. Acta., 585: 67-78.
14. Ohkawa, H. Ohishi, N and Yagi, K, (1979): Assay of lipid peroxides in animal tissue by thiobarbituric acid reaction. Anal. Biochem. 95: 351-358.
15. Ostrowski, SR., Wilbur S., CH. Chou, HR. Poul, YW. Stevens, PM. Allred, N. Roney, M. Fay and Jylenda CA., (1999): ATSDR. 1990-priority lists of hazardous substances. Latent effects, carcinogenesis, neurotoxicology and developmental deficits in humans and animals. Toxicol. Ind. Health., 15: 602-644.
16. Rana, SVS, Singh R and Verma S, (1996): Protective effects of few antioxidants on liver function in rats treated with cadmium and mercury. Indian J. Exp. Biol., 34: 177-179.
17. Rotruck, JR, AL Pope, HE Gamther and Swanson, AB, (1973): Selenium: Biochemical roles as a component of glutathione peroxidase. Science, 179:588.
18. Shaikh, ZA, Vu, T and Zaman, K, (1998): Oxidative stress as a mechanism of chronic cadmium induced hepatotoxicity and renal toxicity and protection by antioxidants. Toxicol. Appl. Pharmacol., 154: 256-263.
19. Sinha, KA. (1972): Colorimetric assay of catalase. Anal. Biochem., 47: 389-394.
20. Stohs SJ, Bagchi, D. Hassoun, E and Bagchi. M. (2000): Oxidative mechanism in the toxicity of chromium and cadmium ions. J. Environ. Pathol. Oncol., 19: 201.
21. Sunanda P, G Pratima and Anand, K, (1997): Protective role of aswaghandha in cadmium induced hepatotoxicity and nephrotoxicity in male mouse. Curr. Sci., 72: 546-547.
22. Sunderman, FW. Jr., (1987): Metal induction of heme oxygenase. Ann. N.Y. Acad. Sci., 514: 65-80.
23. Trivedy N and Rawal, UM, (2000): Hepatoprotective and toxicological evaluation of Andrographis paniculata on severe liver damage. Indian J. Pharmacol., 32: 288-293.
24. Visen, PK S, R Shukla, GK Patnaik, S Kaul, NK Kapoor and Dhawan, BN, (1991): Heptaprotective activity of picroliv, the active principle of Picrorhiza kurroa on rat hepatocytes against paracetamol toxicity. Drug Development Research, 22: 209-219.
25. Visen, PKS, Binduja Shukla GK and Bhawan BN, (1993): Andrographolide protects rat hepatocytes against paracetamol induced damage. J. Ethnopharmacol., 40: 131-136.
26. Yadav, N and Khandelwal, S, (2005): Ameliorative potential of turmeric (Curcuma longa) against cadmium induced hepatotoxicity in mice. Toxicol. Int. 12: 119-124.
27. Zimmerman, HJ, and Seeff, LF, (1970): Enzymes in hepatic diseases, In: E.E. Goodly (Ed.). Diagnostic Enzymology. Lea and Febiger. Philadelphia, pp. 1-38.