Aberrant cell-to-cell coupling in Ca2+-overloaded guinea pig ventricular muscles

American Journal of Physiology - Cell Physiology

Volumn 294, Issue 6, 2008, Pages

  Kurebayashi, Nagomi ^a   Nishizawa, Hiroto ^a   Nakazato, Yuji ^a   Kurihara, Hidetake ^a   Matsushita, Satoshi ^a   Daida, Hiroyuki ^a   Ogawa, Yasuo ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Arrhythmia; Ca2+ transient; Connexin43; Gap junction; Propagation delay

Indexed keywords

CALCIUM ION; CONNEXIN 43; SODIUM CHANNEL; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; HEPTANOL;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GAP JUNCTION; GUINEA PIG; HEART ARRHYTHMIA; HEART CONDUCTION; HEART MUSCLE CELL; HEART VENTRICLE WALL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ANIMAL; CALCIUM SIGNALING; CELL COMMUNICATION; CELL JUNCTION; CONFOCAL MICROSCOPY; DRUG EFFECT; HEART CONTRACTION; HEART PACING; HEART PAPILLARY MUSCLE; HEART VENTRICLE; HEART VENTRICLE TACHYCARDIA; IN VITRO STUDY; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION; TIME;

CAVIA;

ACTION POTENTIALS; ADRENERGIC BETA-AGONISTS; ANIMALS; CALCIUM SIGNALING; CARDIAC PACING, ARTIFICIAL; CELL COMMUNICATION; CONNEXIN 43; GAP JUNCTIONS; GUINEA PIGS; HEART VENTRICLES; HEPTANOL; MICROSCOPY, CONFOCAL; MYOCARDIAL CONTRACTION; PAPILLARY MUSCLES; PHOSPHORYLATION; TACHYCARDIA, VENTRICULAR; TIME FACTORS;

EID: 47249090109     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00413.2007     Document Type: Article

References (48)

1. 2+ signaling, cardiac alternans, and ventricular arrhythmias in intact rat heart. Circ Res 99: e65-e73, 2006.
2. Arutunyan A, Webster DR, Swift LM, Sarvazyan N. Localized injury in cardiomyocyte network: a new experimental model of ischemia-reperfusion arrhythmias. Am J Physiol Heart Circ Physiol 280: H1905-H1915, 2001.
3. 2+ waves in arterially perfused rat hearts. Cardiovasc Res 53: 105-115, 2002.
4. Beardslee MA, Laing JG, Beyer EC, Saffitz JE. Rapid turnover of connexin43 in the adult rat heart. Circ Res 83: 629-635, 1998.
5. Beardslee MA, Lerner DL, Tadros PN, Laing JG, Beyer EC, Yamada KA, Kleber AG, Schuessler RB, Saffitz JE. Dephosphorylation and intracellular redistribution of ventricular connexin43 during electrical uncoupling induced by ischemia. Circ Res 87: 656-662, 2000.
6. Bers DM. Excitation-Contraction Coupling and Cardiac Contractile Force. Dordrecht, Netherlands: Kluwer Academic, 2001.
7. Bridge JH, Smolley JR, Spitzer KW. The relationship between charge movements associated with ICa and INa-Ca in cardiac myocytes. Science 248: 376-378, 1990.
8. Capogrossi MC, Houser SR, Bahinski A, Lakatta EG. Synchronous occurrence of spontaneous localized calcium release from the sarcoplasmic reticulum generates action potentials in rat cardiac ventricular myocytes at normal resting membrane potential. Circ Res 61: 498-503, 1987.
9. Cascio WE, Yang H, Muller-Borer BJ, Johnson TA. Ischemia-induced arrhythmia: the role of connexins, gap junctions, and attendant changes in impulse propagation. J Electrocardiol 38: 55-59, 2005.
10. i waves in cardiac myocytes. Am J Physiol Cell Physiol 270: C148-C159, 1996.
11. Clusin WT. Calcium and cardiac arrhythmias: DADs, EADs, and alternans. Crit Rev Clin Lab Sci 40: 337-375, 2003.
12. Coumel P. Polymorphous ventricular tachyarrhythmias in the absence of structural heart disease. Pacing Clin Electrophysiol 20: 2065-2067, 1997.
13. De Mello WC. Effect of intracellular injection of calcium and strontium on cell communication in heart. J Physiol 250: 231-245, 1975.
14. Eisner DA, Diaz ME, Li Y, O'Neill SC, Trafford AW. Stability and instability of regulation of intracellular calcium. Exp Physiol 90: 3-12, 2005.
15. Fabiato A, Fabiato F. Excitation-contraction coupling of isolated cardiac fibers with disrupted or closed sarcolemmas. Calcium-dependent cyclic and tonic contractions. Circ Res 31: 293-307, 1972.
16. Fedida D, Noble D, Rankin AC, Spindler AJ. The arrhythmogenic transient inward current iTI and related contraction in isolated guinea-pig ventricular myocytes. J Physiol 392: 523-542, 1987.
17. Firek L, Weingart R. Modification of gap junction conductance by divalent cations and protons in neonatal rat heart cells. J Mol Cell Cardiol 27: 1633-1643, 1995.
18. 2+ waves in Langendorff-perfused rat heart revealed by real-time confocal microscopy. Circ Res 86: 1093-1099, 2000.
19. 2+ waves in multicellular preparations from guinea pig ventricle. Am J Physiol Cell Physiol 287: C1646-C1656, 2004.
20. 2+ overload causes delayed propagation of action potentials and increased non-phosphorylated connexin43 level in guinea pig ventricular muscle (Abstract). Biophysical Society Annual Meeting Abstracts Issue: 221a, 2006.
21. Laird DW, Puranam KL, Revel JP. Turnover and phosphorylation dynamics of connexin43 gap junction protein in cultured cardiac myocytes. Biochem J 273: 67-72, 1991.
22. Lazrak A, Peracchia C. Gap junction gating sensitivity to physiological internal calcium regardless of pH in Novikoff hepatoma cells. Biophys J 65: 2002-2012, 1993.
23. Lee HC, Mohabir R, Smith N, Franz MR, Clusin WT. Effect of ischemia on calcium-dependent fluorescence transients in rabbit hearts containing indo 1. Correlation with monophasic action potentials and contraction. Circulation 78: 1047-1059, 1988.
24. Li WE, Nagy JI. Connexin43 phosphorylation state and intercellular communication in cultured astrocytes following hypoxia and protein phosphatase inhibition. Eur J Neurosci 12: 2644-2650, 2000.
25. Marban E, Robinson SW, Wier WG. Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle. J Clin Invest 78: 1185-1192, 1986.
26. Matsushita T, Oyamada M, Fujimoto K, Yasuda Y, Masuda S, Wada Y, Oka T, Takamatsu T. Remodeling of cell-cell and cell-extracellular matrix interactions at the border zone of rat myocardial infarcts. Circ Res 85: 1046-1055, 1999.
27. Matsushita S, Kurihara H, Watanabe M, Okada T, Sakai T, Amano A. Alterations of phosphorylation state of connexin 43 during hypoxia and reoxygenation are associated with cardiac function. J Histochem Cytochem 54: 343-353, 2006.
28. Miura M, Ishide N, Oda H, Sakurai M, Shinozaki T, Takishima T. Spatial features of calcium transients during early and delayed afterdepolarizations. Am J Physiol Heart Circ Physiol 265: H439-H444, 1993.
29. 2+ waves during triggered propagated contractions in intact trabeculae. Am J Physiol Heart Circ Physiol 274: H266-H276, 1998.
30. i in perfused rabbit hearts. Circ Res 69: 1525-1537, 1991.
31. Moreno AP. Connexin phosphorylation as a regulatory event linked to channel gating. Biochim Biophys Acta 1711: 164-171, 2005.
32. Musil LS, Cunningham BA, Edelman GM, Goodenough DA. Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines. J Cell Biol 111: 2077-2088, 1990.
33. Nagy JI, Li WE, Roy C, Doble BW, Gilchrist JS, Kardami E, Hertzberg EL. Selective monoclonal antibody recognition and cellular localization of an unphosphorylated form of connexin43. Exp Cell Res 236: 127-136, 1997.
34. 2+ dynamics in cardiomyocytes at the border zone of myocardial infarcts. Cell Commun Adhes 8: 335-338, 2001.
35. Postma AV, Denjoy I, Hoorntje TM, Lupoglazoff JM, Da Costa A, Sebillon P, Mannens MM, Wilde AAM, Guicheney P. Absence of calsequestrin 2 causes severe forms of catecholaminergic polymorphic ventricular tachycardia. Circ Res 91: e21-e26, 2002.
36. Priori SG, Napolitano C, Tiso N, Memmi M, Vignati G, Bloise R, Sorrentino V, Danieli GA. Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia. Circulation 103: 196-200, 2001.
37. Ravens U, Wettwer E, Hala O. Pharmacological modulation of ion channels and transporters. Cell Calcium 35: 575-582, 2004.
38. 2+ transients in Langendorff-perfused mouse hearts. Am J Physiol Cell Physiol 284: C1654-C1668, 2003.
39. Sipido KR. Calcium overload, spontaneous calcium release, and ventricular arrhythmias. Heart Rhythm 3: 977-979, 2006.
40. +-induced ventricular fibrillation. Physiol Res 50: 247-259, 2001.
41. Turner MS, Haywood GA, Andreka P, You L, Martin PE, Evans WH, Webster KA, Bishopric NH. Reversible connexin 43 dephosphorylation during hypoxia and reoxygenation is linked to cellular ATP levels. Circ Res 95: 726-733, 2004.
42. Van Rijen HVM, Eckardt D, Degen J, Theis M, Ott T, Willecke K, Jongsma HJ, Opthof T, de Bakker JMT. Slow conduction and enhanced anisotropy increase the propensity for ventricular tachyarrhythmias in adult mice with induced deletion of connexin43. Circulation 109: 1048-1055, 2004.
43. Van Veen AA, van Rijen HV, Opthof T. Cardiac gap junction channels: modulation of expression and channel properties. Cardiovasc Res 51: 217-229, 2001.
44. Vassalle M, Lin CI. Calcium overload and cardiac function. J Biomed Sci 11: 542-565, 2004.
45. Weingart R. The actions of ouabain on intercellular coupling and conduction velocity in mammalian ventricular muscle. J Physiol 264: 341-365, 1977.
46. ++. J Gen Physiol 95: 1061-1075, 1990.
47. 2+] transient, membrane potential, and contraction. J Gen Physiol 83: 395-415, 1984.
48. 2+ 'sparks' and waves in intact ventricular muscle resolved by confocal imaging. Circ Res 81: 462-469, 1997.