Toxicological aspects of the use of dextran microspheres and thermogelling ethyl(hydroxyethyl) cellulose (EHEC) as nasal drug delivery systems

International Journal of Pharmaceutics

Volumn 128, Issue 1-2, 1996, Pages 9-21

  Pereswetoff Morath, Lena ^a,c   Bjurstrom, Sivert ^b   Khan, Rauf ^b   Dahlin, Maria ^a   Edman, Peter ^a,b  

^a UPPSALA UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c Astra Arcus AB   (Sweden)

Author keywords

ciliotoxicity; dextran microsphere; histology; nasal administration; thermogelling polymer

Indexed keywords

CELLULOSE DERIVATIVE; CELLULOSE ETHYL HYDROXYETHYL ETHER; DEXTRAN; MICROSPHERE; NEUTRAL INSULIN; POLYMER; SEPHADEX; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL HYPERPLASIA; CILIARY MOTILITY; CONTROLLED STUDY; DEHYDRATION; DRUG DELIVERY SYSTEM; GEL; HISTOLOGY; INTRANASAL DRUG ADMINISTRATION; MALE; MICROSCOPY; MUCOCILIARY CLEARANCE; NONHUMAN; NOSE MUCOSA; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY;

EID: 0029923688     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(95)04205-9     Document Type: Article

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