The LTK63 adjuvant improves protection conferred by Ag85B DNA-protein prime-boosting vaccination against Mycobacterium tuberculosis infection by dampening IFN-γ response

Vaccine

Volumn 26, Issue 33, 2008, Pages 4237-4243

  Palma, Carla ^a   Iona, Elisabetta ^a   Giannoni, Federico ^a   Pardini, Manuela ^a   Brunori, Lara ^a   Fattorini, Lanfranco ^a   Del Giudice, Giuseppe ^b   Cassone, Antonio ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b NOVARTIS VACCINES AND DIAGNOSTICS   (Italy)

Author keywords

Adjuvant; Mycobacterium tuberculosis; Th1 responses

Indexed keywords

DNA VACCINE; ESCHERICHIA COLI ENTEROTOXIN; GAMMA INTERFERON; IMMUNOGLOBULIN G2B; LTK 63; PROTEIN AG85B; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GROWTH; BONE MARROW CELL; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFECT; FEMALE; HUMORAL IMMUNITY; INNATE IMMUNITY; MACROPHAGE; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; SPLEEN CELL; TH1 CELL; TUBERCULOSIS; VACCINATION;

ACYLTRANSFERASES; ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL TOXINS; CD4-POSITIVE T-LYMPHOCYTES; COLONY COUNT, MICROBIAL; ENTEROTOXINS; ESCHERICHIA COLI PROTEINS; FEMALE; IMMUNIZATION, SECONDARY; IMMUNOGLOBULIN G; LUNG; MICE; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS; TUBERCULOSIS VACCINES; VACCINES, DNA; VACCINES, SUBUNIT;

EID: 47149094823     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2008.05.050     Document Type: Article

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