Cost of Radiotherapy Versus NSAID Administration for Prevention of Heterotopic Ossification After Total Hip Arthroplasty

International Journal of Radiation Oncology Biology Physics

Volumn 71, Issue 5, 2008, Pages 1460-1464

  Strauss, Jonathan B ^a   Chen, Sea S ^a   Shah, Anand P ^a   Coon, Alan B ^a   Dickler, Adam ^b  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b Mary Hospital   (United States)

Author keywords

Cost effectiveness; Economics; Heterotopic ossification; Nonsteroidal anti inflammatory drug; Radiotherapy

Indexed keywords

BONE; CHEMOTHERAPY; COMPENSATION (PERSONNEL); COST ACCOUNTING; COST EFFECTIVENESS; DRUG DELIVERY; DRUG DOSAGE; ELECTROTHERAPEUTICS; ESTIMATION; HEALTH; RADIOTHERAPY; SURGERY; WAGES; WEIGHT CONTROL;

ADDITIONAL COSTS; BONE FORMATION; CENSUS BUREAU; ECONOMICS; ESTIMATED COSTS; GASTROINTESTINAL BLEEDING; GROUP CODES; HETEROTOPIC OSSIFICATION; NON-STEROIDAL ANTI-INFLAMMATORY DRUGS; NONSTEROIDAL ANTI-INFLAMMATORY DRUG; PRODUCTIVITY LOSSES; QUALITY-OF-LIFE; REVISION TOTAL HIP ARTHROPLASTY; TOTAL HIP ARTHROPLASTY; TREATMENT FAILURE;

COST BENEFIT ANALYSIS;

INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT;

ARTICLE; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DRUG COST; DRUG EFFICACY; GASTROINTESTINAL HEMORRHAGE; HEALTH CARE COST; HETEROTOPIC OSSIFICATION; HOSPITALIZATION; HUMAN; JOINT FUNCTION; JOINT MOBILITY; MEDICARE; MORBIDITY; PRIORITY JOURNAL; PROPHYLAXIS; RADIATION DOSE; SENSITIVITY ANALYSIS; SURGICAL TECHNIQUE; TOTAL HIP PROSTHESIS;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHROPLASTY, REPLACEMENT, HIP; COST-BENEFIT ANALYSIS; EFFICIENCY; GASTROINTESTINAL HEMORRHAGE; HEALTH CARE COSTS; HOSPITALIZATION; HUMANS; MEDICARE ASSIGNMENT; MIDDLE AGED; OSSIFICATION, HETEROTOPIC; RADIOTHERAPY; REOPERATION; UNITED STATES;

EID: 47149093887     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2007.12.006     Document Type: Article

References (26)

1. Chalmers J., Gray D.H., and Rush J. Observations on the induction of bone in soft tissues. J Bone Joint Surg Br 57 (1975) 36-45
2. Brooker A.F., Bowerman J.W., Robinson R.A., et al. Ectopic ossification following total hip replacement: Incidence and a method of classification. J Bone Joint Surg Am 55 (1973) 1629-1632
3. Pohl F., Seufert J., Tauscher A., et al. The influence of heterotopic ossification on functional status of hip joint following total hip arthroplasty. Strahlenther Onkol 181 (2005) 529-533
4. Hu H., Kuijpers W., Slooff T., et al. The effect of biphosphonate on induced heterotopic bone. Clin Orthop Relat Res 272 (1991) 259-267
5. Haran M., Bhuta T., and Lee B. Pharmacological interventions for treating acute heterotopic ossification. Cochrane Database Syst Rev (2004) Issue 4: Art. No. CD003321
6. Coventry M.B., and Scanlon P.W. The use of radiation to discourage ectopic bone: A nine-year study in surgery about the hip. J Bone Joint Surg Am 63 (1981) 201-208
7. Craven P.L., and Urist M.R. Osteogenesis by radioisotope labeled cell populations in implants of bone matrix under the influence of ionizing radiation. Clin Orthop Relat Res 76 (1971) 231-233
8. Jee W.S., and Ma Y.F. The in vivo anabolic actions of prostaglandins in bone. Bone 21 (1997) 297-304
9. Sell S., Wilms R., Jany R., et al. The suppression of heterotopic ossifications: Radiation versus NSAID therapy-A prospective study. J Arthroplas 13 (1998) 854-859
10. Kolbl O., Flentje M., Eulert J., et al. Prospective study on the prevention of heterotopic ossification after total hip replacement: Nonsteroidal anti-inflammatory agents versus radiation therapy. Strahlenther Onkol 173 (1997) 677-682
11. Pakos E., and Ionnidis J. Radiotherapy vs. nonsteroidal anti-inflammatory drugs for the prevention of heterotopic ossification after major hip procedures: A meta-analysis of randomized trials. Int J Radiat Oncol Biol Phys 60 (2004) 888-895
12. Karunakar M.A., Sen A., Bosse M.J., et al. Indomethacin as prophylaxis for heterotopic ossification after the operative treatment of fractures of the acetabulum. J Bone Joint Surg [Br] 88-B (2006) 1613-1617
13. Moore K.D., Goss K., and Anglen J.O. Indomethacin versus radiation therapy for prophylaxis against heterotopic ossification in acetabular fractures. J Bone Joint Surg [Br] 80-B (1998) 259-263
14. Knelles D., Barthel T., Karrer A., et al. Prevention of heterotopic ossification after total hip replacement. J Bone Joint Surg [Br] 79-B (1997) 596-602
15. Healy W.L., Lo T.C., DeSimone A.A., et al. Single-dose irradiation for the prevention of heterotopic ossification after total hip arthroplasty: A comparison of doses of five hundred and fifty and seven hundred centigray. J Bone Joint Surg [Am] 77-A (1995) 590-595
16. Inpatient PPS PC Pricer. Available from: http://www.cms.hhs.gov/PCPricre/03_inpatient.asp. Accessed November 7, 2007.
17. Drugstore.com. Available from: http://www.drugstore.com/pharmacy/prices/drugprice.asp#00378014301_prices. Accessed November 7, 2007.
18. U.S. Census Bureau, Current Population Survey, 2007 Annual Social and Economic Supplement. Available from: http://pubdb3.census.gov/macro/032007/perinc/new01_001.htm. Accessed November 6, 2007.
19. Fransen M., Anderson C., Douglas J., et al. Safety and efficacy of routine postoperative ibuprofen for pain and disability related to ectopic bone formation after hip replacement surgery (HIPAID): Randomized controlled trial. BMJ 333 (2006) 519 Epub 2006 August 2
20. Hayman J.A., Lash K.A., Tao M.L., et al. A comparison of two methods for estimating the technical costs of external beam radiation therapy. Int J Radiat Oncol Biol Phys 47 (2000) 461-467
21. Potter B.K., Burns T.C., Lacap A.P., et al. Heterotopic ossification following traumatic and combat-related amputations: Prevalence, risk factors, and preliminary results of excision. J Bone Joint Surg Am 89 (2007) 476-486
22. Singh G. Recent considerations in nonsteroidal anti-inflammatory drug gastropathy. Am J Med 105 (1998) 31S-38S
23. Gabriel S.E., Jaakkimainen L., and Bombardier C. Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs: A meta-analysis. Ann Intern Med 115 (1991) 787-796
24. Singh G., Ramey D.R., Morfeld D., et al. Gastrointestinal tract complications of nonsteroidal anti-inflammatory drug treatment in rheumatoid arthritis: A prospective observational cohort study. Arch Intern Med 156 (1996) 1530-1536
25. Balboni T.A., Gobezie R., and Mamon H.J. Heterotopic ossification: pathophysiology, clinical features, and the role of radiotherapy for prophylaxis. Int J Radiat Oncol Biol Phys 65 (2006) 1289-1299
26. Singh G., and Triadafilopoulos G. Epidemiology of NSAID induced gastrointestinal complications. J Rheumatol 26 Suppl. (1999) 18-24