Heterotopic ossification: Pathophysiology, clinical features, and the role of radiotherapy for prophylaxis

International Journal of Radiation Oncology Biology Physics

Volumn 65, Issue 5, 2006, Pages 1289-1299

  Balboni, Tracy A ^a   Gobezie, Reuben ^a   Mamon, Harvey J ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Heterotopic bone; Heterotopic ossification; Prophylaxis; Radiation therapy

Indexed keywords

BONE; CELLS; DRUG PRODUCTS; HEALTH RISKS; JOINTS (ANATOMY); MEDICAL PROBLEMS; PATHOLOGY; RADIOTHERAPY;

GENETIC ABNORMALITIES; HETEROTOPIC BONE; HETEROTOPIC OSSIFICATION (HO); NEUROLOGIC INJURY; PATHOPHYSIOLOGY; PROPHYLAXIS;

TUMORS;

BISPHOSPHONIC ACID DERIVATIVE; INDOMETACIN; LOW MOLECULAR WEIGHT HEPARIN; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN INHIBITOR; WARFARIN;

BONE DEMINERALIZATION; BONE MALFORMATION; BRAIN INJURY; CARCINOGENESIS; CLINICAL FEATURE; DEEP VEIN THROMBOSIS; GASTRITIS; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL SYMPTOM; GENETIC DISORDER; HETEROTOPIC OSSIFICATION; HIGH RISK POPULATION; HUMAN; INCIDENCE; INJURY; JOINT; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROPHYLAXIS; PROSTHESIS; PSEUDARTHROSIS; RANGE OF MOTION; REVIEW; RISK FACTOR; SOFT TISSUE; STEM CELL; STOMACH ULCER; HIP ARTHROPLASTY; HIP PROSTHESIS;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHROPLASTY, REPLACEMENT, HIP; HIP PROSTHESIS; HUMANS; INDOMETHACIN; OSSIFICATION, HETEROTOPIC; RISK FACTORS;

EID: 33748557464     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2006.03.053     Document Type: Review

References (64)

1. Naraghi F.F., DeCoster T.A., Moneim M.S., et al. Heterotopic ossification. Orthopedics 19 (1996) 145-151
2. Sawyer J.R., Myers M.A., Rosier R.N., et al. Heterotopic ossification. Clinical and cellular aspects. Calcif Tissue Int 49 (1991) 208-215
3. Garland D.E. A clinical perspective on common forms of acquired heterotopic ossification. Clin Orthop Relat Res (1991) 13-29
4. Balen P.F., and Helms C.A. Bony ankylosis following thermal and electrical injury. Skeletal Radiol 30 (2001) 393-397
5. Toyoda T., Matsumoto H., Tsuji T., et al. Heterotopic ossification after total knee arthroplasty. J Arthroplasty 18 (2003) 760-764
6. Sperling J.W., Cofield R.H., and Rowland C.M. Heterotopic ossification after total shoulder arthroplasty. J Arthroplasty 15 (2000) 179-182
7. Taylor D.C., Englehardt D.L., and Bassett III F.H. Syndesmosis sprains of the ankle. The influence of heterotopic ossification. Am J Sports Med 20 (1992) 146-150
8. Rubin M.M., and Cozzi G.M. Heterotopic ossification of the temporomandibular joint in a burn patient. J Oral Maxillofac Surg 44 (1986) 897-899
9. Ryan J.B., Wheeler J.H., Hopkinson W.J., et al. Quadriceps contusions. West Point update. Am J Sports Med 19 (1991) 299-304
10. Reardon M.J., Tillou A., Mody D.R., et al. Heterotopic calcification in abdominal wounds. Am J Surg 173 (1997) 145-147
11. Garland D.E., Blum C.E., and Waters R.L. Periarticular heterotopic ossification in head-injured adults. Incidence and location. J Bone Joint Surg Am 62 (1980) 1143-1146
12. An H.S., Ebraheim N., Kim K., et al. Heterotopic ossification and pseudoarthrosis in the shoulder following encephalitis. A case report and review of the literature. Clin Orthop Relat Res (1987) 291-298
13. Lorber J. Ectopic ossification in tuberculous meningitis. Arch Dis Child 28 (1953) 98-103
14. Stoikovic J.P., Bonfiglio M., and Paul W.D. Myositis ossificans complicating poliomyelitis. Arch Phys Med Rehabil 36 (1955) 236-243
15. Ishikawa K., Izumi K., and Kitagawa T. Heterotopic ossification of the hip as a complication of tetanus. Clin Orthop Relat Res (1982) 249-255
16. Roberts P.H. Heterotopic ossification complicating paralysis of intracranial origin. J Bone Joint Surg Am 50 (1968) 70-77
17. Radt P. Periarticular ectopic ossification in hemiplegics. Geriatrics 25 (1970) 142-143 passim
18. Roberts J.B., and Pankratz D.G. The surgical treatment of heterotopic ossification at the elbow following long-term coma. J Bone Joint Surg Am 61 (1979) 760-763
19. Cohen R.B., Hahn G.V., Tabas J.A., et al. The natural history of heterotopic ossification in patients who have fibrodysplasia ossificans progressiva. A study of forty-four patients. J Bone Joint Surg Am 75 (1993) 215-219
20. Shore E.M., Ahn J., Jan de Beur S., et al. Paternally inherited inactivating mutations of the GNAS1 gene in progressive osseous heteroplasia. N Engl J Med 346 (2002) 99-106
21. Orzel J.A., and Rudd T.G. Heterotopic bone formation. Clinical, laboratory, and imaging correlation. J Nucl Med 26 (1985) 125-132
22. Brooker A.F., Bowerman J.W., Robinson R.A., et al. Ectopic ossification following total hip replacement. Incidence and a method of classification. J Bone Joint Surg Am 55 (1973) 1629-1632
23. Urist M.R. Bone. Formation by autoinduction. Science 150 (1965) 893-899
24. Chalmers J., Gray D.H., and Rush J. Observations on the induction of bone in soft tissues. J Bone Joint Surg Br 57 (1975) 36-45
25. Shafritz A.B., Shore E.M., Gannon F.H., et al. Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva. N Engl J Med 335 (1996) 555-561
26. Reddi A.H. Bone morphogenetic proteins, bone marrow stromal cells, and mesenchymal stem cells. Maureen Owen revisited. Clin Orthop Relat Res (1995) 115-119
27. Hannallah D., Peng H., Young B., et al. Retroviral delivery of Noggin inhibits the formation of heterotopic ossification induced by BMP-4, demineralized bone matrix, and trauma in an animal model. J Bone Joint Surg Am 86-A (2004) 80-91
28. Spencer R.F. The effect of head injury on fracture healing. A quantitative assessment. J Bone Joint Surg Br 69 (1987) 525-528
29. Ahrengart L., Lindgren U., and Reinholt F.P. Comparative study of the effects of radiation, indomethacin, prednisolone, and ethane-1-hydroxy-1,1-diphosphonate (EHDP) in the prevention of ectopic bone formation. Clin Orthop Relat Res (1988) 265-273
30. Matta J.M., and Siebenrock K.A. Does indomethacin reduce heterotopic bone formation after operations for acetabular fractures? A prospective randomised study. J Bone Joint Surg Br 79 (1997) 959-963
31. McLaren A.C. Prophylaxis with indomethacin for heterotopic bone after open reduction of fractures of the acetabulum. J Bone Joint Surg Am 72 (1990) 245-247
32. Neal B., Gray H., MacMahon S., et al. Incidence of heterotopic bone formation after major hip surgery. ANZ J Surg 72 (2002) 808-821
33. McCarthy E.F., and Sundaram M. Heterotopic ossification. A review. Skeletal Radiol 34 (2005) 609-619
34. Pape H.C., Marsh S., Morley J.R., et al. Current concepts in the development of heterotopic ossification. J Bone Joint Surg Br 86 (2004) 783-787
35. DeLee J., Ferrari A., and Charnley J. Ectopic bone formation following low friction arthroplasty of the hip. Clin Orthop Relat Res (1976) 53-59
36. Eggli S., and Woo A. Risk factors for heterotopic ossification in total hip arthroplasty. Arch Orthop Trauma Surg 121 (2001) 531-535
37. Purtill J.J., Eng K., Rothman R.H., et al. Heterotopic ossification. Incidence in cemented versus cementless total hip arthroplasty. J Arthroplasty 11 (1996) 58-63
38. Ebinger T., Roesch M., Kiefer H., et al. Influence of etiology in heterotopic bone formation of the hip. J Trauma 48 (2000) 1058-1062
39. Munster A.M., Bruck H.M., Johns L.A., et al. Heterotopic calcification following burns. A prospective study. J Trauma 12 (1972) 1071-1074
40. Padgett D.E., Holley K.G., Cummings M., et al. The efficacy of 500 CentiGray radiation in the prevention of heterotopic ossification after total hip arthroplasty. A prospective, randomized, pilot study. J Arthroplasty 18 (2003) 677-686
41. Cooley L.M., and Goss R.J. The effects of transplantation and x-irradiation on the repair of fractured bones. Am J Anat 102 (1958) 167-181
42. Craven P.L., and Urist M.R. Osteogenesis by radioisotope labelled cell populations in implants of bone matrix under the influence of ionizing radiation. Clin Orthop Relat Res 76 (1971) 231-233
43. Neuhauser E.B., Wittenborg M.H., Berman C.Z., et al. Irradiation effects of roentgen therapy on the growing spine. Radiology 59 (1952) 637-650
44. Coventry M.B., and Scanlon P.W. The use of radiation to discourage ectopic bone. A nine-year study in surgery about the hip. J Bone Joint Surg Am 63 (1981) 201-208
45. Sylvester J.E., Greenberg P., Selch M.T., et al. The use of postoperative irradiation for the prevention of heterotopic bone formation after total hip replacement. Int J Radiat Oncol Biol Phys 14 (1988) 471-476
46. Lo T.C., Healy W.L., Covall D.J., et al. Heterotopic bone formation after hip surgery. Prevention with single-dose postoperative hip irradiation. Radiology 168 (1988) 851-854
47. Pellegrini Jr. V.D., Konski A.A., Gastel J.A., et al. Prevention of heterotopic ossification with irradiation after total hip arthroplasty. Radiation therapy with a single dose of eight hundred centigray administered to a limited field. J Bone Joint Surg Am 74 (1992) 186-200
48. Healy W.L., Lo T.C., DeSimone A.A., et al. Single-dose irradiation for the prevention of heterotopic ossification after total hip arthroplasty. A comparison of doses of five hundred and fifty and seven hundred centigray. J Bone Joint Surg Am 77 (1995) 590-595
49. Kantorowitz D.A., Miller G.J., Ferrara J.A., et al. Preoperative versus postoperative irradiation in the prophylaxis of heterotopic bone formation in rats. Int J Radiat Oncol Biol Phys 19 (1990) 1431-1438
50. Seegenschmiedt M.H., Keilholz L., Martus P., et al. Prevention of heterotopic ossification about the hip. Final results of two randomized trials in 410 patients using either preoperative or postoperative radiation therapy. Int J Radiat Oncol Biol Phys 39 (1997) 161-171
51. Gregoritch S.J., Chadha M., Pelligrini V.D., et al. Randomized trial comparing preoperative versus postoperative irradiation for prevention of heterotopic ossification following prosthetic total hip replacement. Preliminary results. Int J Radiat Oncol Biol Phys 30 (1994) 55-62
52. Konski A., Weiss C., Rosier R., et al. The use of postoperative irradiation for the prevention of heterotopic bone after total hip replacement with biologic fixation (porous coated) prosthesis. An animal model. Int J Radiat Oncol Biol Phys 18 (1990) 861-865
53. Jasty M., Schutzer S., Tepper J., et al. Radiation-blocking shields to localize periarticular radiation precisely for prevention of heterotopic bone formation around uncemented total hip arthroplasties. Clin Orthop Relat Res (1990) 138-145
54. Burd T.A., Hughes M.S., and Anglen J.O. Heterotopic ossification prophylaxis with indomethacin increases the risk of long-bone nonunion. J Bone Joint Surg Br 85 (2003) 700-705
55. Burd T.A., Lowry K.J., and Anglen J.O. Indomethacin compared with localized irradiation for the prevention of heterotopic ossification following surgical treatment of acetabular fractures. J Bone Joint Surg Am 83-A (2001) 1783-1788
56. Pakos E.E., and Ioannidis J.P. Radiotherapy vs. nonsteroidal anti-inflammatory drugs for the prevention of heterotopic ossification after major hip procedures. A meta-analysis of randomized trials. Int J Radiat Oncol Biol Phys 60 (2004) 888-895
57. Kim J.H., Chu F.C., Woodard H.Q., et al. Radiation-induced soft-tissue and bone sarcoma. Radiology 129 (1978) 501-508
58. Howell S.J., and Shalet S.M. Spermatogenesis after cancer treatment. Damage and recovery. J Natl Cancer Inst Monogr (2005) 12-17
59. Patel H.Y.C., Silverman C.L., Carrascosa L., Paris K.J., Jose B.O., and Spanos W.J. Evaluation of scrotal and testicular dose when using radiation for heterotopic ossification prophylaxis. Int J Radiat Oncol Biol Phys 63 (2005) S340-S431
60. Heyd R., Strassmann G., Schopohl B., et al. Radiation therapy for the prevention of heterotopic ossification at the elbow. J Bone Joint Surg Br 83 (2001) 332-334
61. Lo T.C., Pfeifer B.A., Smiley P.M., et al. Case report. Radiation prevention of heterotopic ossification after bone and joint surgery in sites other than hips. Br J Radiol 69 (1996) 673-677
62. Lane J.E., Dean R.J., Foulkes G.D., et al. Idiopathic heterotopic ossification in the intensive care setting. Postgrad Med J 78 (2002) 494-495
63. Glaser D.L., Economides A.N., Wang L., et al. In vivo somatic cell gene transfer of an engineered Noggin mutein prevents BMP4-induced heterotopic ossification. J Bone Joint Surg Am 85-A (2003) 2332-2342
64. Schafer S.J., Schafer L.O., Anglen J.O., et al. Heterotopic ossification in rehabilitation patients who have had internal fixation of an acetabular fracture. J Rehabil Res Dev 37 (2000) 389-393