Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro

Thorax

Volumn 63, Issue 7, 2008, Pages 621-626

  Geraghty, P ^a   Rogan, M P ^a   Greene, C M ^a   Brantly, M L ^b   O'Neill, S J ^a   Taggart, C C ^a,c   McElvaney, N G ^a  

^a BEAUMONT HOSPITAL   (Ireland)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; CATHEPSIN B; GELATINASE A; LACTOFERRIN; LEUKOCYTE ELASTASE; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR;

ADULT; ALPHA 1 ANTITRYPSIN DEFICIENCY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; DRUG MECHANISM; DRY POWDER; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; LUNG LAVAGE; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UNITED STATES;

ADMINISTRATION, INHALATION; ALPHA 1-ANTITRYPSIN; ALPHA 1-ANTITRYPSIN DEFICIENCY; BRONCHOALVEOLAR LAVAGE FLUID; CATHEPSIN B; FEMALE; HUMANS; LEUKOCYTE ELASTASE; MALE; MATRIX METALLOPROTEINASE 2; MIDDLE AGED; MONOCYTES; PNEUMONIA; SERINE PROTEINASE INHIBITORS;

EID: 47049124349     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.2007.088559     Document Type: Article

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