The pathobiology of psoriatic synovium

Current Opinion in Rheumatology

Volumn 20, Issue 4, 2008, Pages 404-407

  Boyle, David L ^a   Kavanaugh, Arthur ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Enthesitis; Pathogenesis; Psoriasis; Psoriatic arthritis; Synovitis

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 1BETA CONVERTING ENZYME;

AUTOIMMUNITY; B LYMPHOCYTE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INNATE IMMUNITY; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PSORIATIC ARTHRITIS; REVIEW; SKIN INFLAMMATION; SYNOVITIS; SYNOVIUM; T LYMPHOCYTE; TREATMENT RESPONSE; ANIMAL; HUMAN; MOUSE;

ANIMALS; ARTHRITIS, PSORIATIC; HUMANS; MICE; SYNOVITIS;

EID: 47049123313     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/BOR.0b013e32830435a7     Document Type: Review

References (17)

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2. Turkiewicz AM, Moreland LW. Psoriatic arthritis: current concepts on pathogenesis-oriented therapeutic options. Arthritis Rheum 2007; 56:1051-1066.
3. McGonagle D, Lories RJ, Tan AL, Benjamin M. The concept of a 'synovioentheseal complex' and its implications for understanding joint inflammation and damage in psoriatic arthritis and beyond. Arthritis Rheum 2007; 56:2482-2491. These authors pose a novel way of considering PsA, merging anatomical observations with immunologic hypotheses.
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5. Gisondi P, Tinazzi I, El-Dalati, et al. Lower limb enthesopathy in patients with psoriasis without clinical signs of arthropathy: a hospital-based case-control study. Ann Rheum Dis 2008; 67:26-30 An important study demonstrating subclinical entheseal involvement in asymptomatic patients having psoriasis. The finding that such abnormalities are common may have relevance as regards the etiology of PsA and is of great clinical relevance.
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7. van Kuijk AW, Reinders-Blankert P, Smeets TJ, et al. Detailed analysis of the cell infiltrate and the expression of mediators of synovial inflammation and joint destruction in the synovium of patients with psoriatic arthritis: implications for treatment. Ann Rheum Dis 2006; 65:1551-1557.
8. Canete JD, Santiago B, Cantaert T, et al. Ectopic lymphoid neogenesis in psoriatic arthritis. Ann Rheum Dis 2007; 66:720-726. A detailed analysis of psoriatic synovium explores the possibility of altered lymphocytic architecture and potential function. This has relevance for the therapy of PsA.
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17. Lande R, Gregorio J, Facchinetti V, et al. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 2007; 449:564-569. An interesting study of innate immune activation of plasmacytoid dendritic cells in psoriatic skin.