Syntheses and Properties of Kanamycin C Derivatives Active Against Resistant Bacteria

The Journal of Antibiotics

Volumn 30, Issue 12, 1977, Pages 1150-1152

  Kondo, Shinichi ^a   Miyasaka, Tsuyoshi ^a   Yoshida, Kenzaburo ^a   Iinuma, Katsuharu ^a   Umezawa, Hamao ^a  

^a INSTITUTE OF MICROBIAL CHEMISTRY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3' DEOXYKANAMYCIN C; 3,4 DIDEOXYKANAMYCIN C; AMIKACIN; KANAMYCIN B; KANAMYCIN C; KANAMYCIN C DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BACILLUS SUBTILIS; DRUG ANALYSIS; DRUG COMPARISON; DRUG RESISTANCE; DRUG SCREENING; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERANCE; DRUG TOXICITY; ESCHERICHIA COLI; IN VITRO STUDY; INTOXICATION; INTRAVENOUS DRUG ADMINISTRATION; KLEBSIELLA PNEUMONIAE; MOUSE; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; THEORETICAL STUDY; THIN LAYER CHROMATOGRAPHY;

CHEMISTRY; ESCHERICHIA COLI; KANAMYCIN; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; PSEUDOMONAS; STAPHYLOCOCCUS AUREUS;

EID: 0017592237     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.7164/antibiotics.30.1150     Document Type: Article

References (7)

1. UMEZAWA, H.: Biochemical mechanism of resistance to aminoglycoside antibiotics. Advances in Carbohydrate Chemistry and Biochemistry. Vol. 30 (ed. by R. S. TIPSON & D. HORTON), pp. 183–225, Academic Press, New York, 1974.
2. UMEZAWA, H.: Biochemical mechanism of resistance to aminoglycoside antibiotics. Drug Action and Drug Resistance in Bacteria. 2. Aminoglycoside Antibiotics (ed. by S. MITSU-HASHI), pp. 211–248, University of Tokyo Press, Tokyo, 1975.
3. YAGISAWA, M.; S. KONDO, T. TAKEUCHI & H. UMEZAWA: Aminoglycoside 6'-N-acetyltrans-ferase of Pseudomonas aeruginosa: Structural requirements of substrate. J. Antibiotics 28: 486–489, 1975.
4. KONDO, S.; K. IINUMA, M. HAMADA, K. MAEDA & H. UMEZAWA : Syntheses of isoseryl derivatives of kanamycins and their antibacterial activities. J. Antibiotics 27: 90–93, 1974.
5. TAKAGI, Y.; T. MIYAKE, T. TSUCHIYA, S. UMEZAWA: Synthesis of 3'-deoxykanamycin B. J. Antibiotics 26: 403–406, 1973.
6. KONDO, S.; K. IINUMA, H. YAMAMOTO, K. MAEDA & H. UMEZAWA: Syntheses of 1-N-[(S)-4-amino-2-hydroxybutyryl]-kanamycin B and -3',4'-dideoxykanamycin B active against kanamycin-resistant bacteria. J. Antibiotics 26: 412–415, 1973.
7. See, for instance, KOCH, K. F.; J. A. RHOADES, E. W. HAGAMAN & E. WENKERT: Carbon-13 nuclear magnetic resonance spectral analysis of tobramycin and related antibiotics. J. Am. Chem. Soc. 96: 3300–3305, 1974.