Synthesis and in vitro evaluation of 18F-β-carboline alkaloids as PET ligands

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 51, Issue 6, 2008, Pages 277-282

  Blom, Elisabeth ^a   Karimi, Farhad ^a   Eriksson, Olof ^a   Hall, Håkan ^b   Långström, Bengt ^a,b  

^a UPPSALA UNIVERSITY   (Sweden)

^b Box 967   (Sweden)

Author keywords

Harmine analogues; MAO A; Nucleophilic 18F fluorination; One step labelling; carboline alkaloids

Indexed keywords

ALKALOIDS; CHELATION; METABOLITES; POSITRON EMISSION TOMOGRAPHY; RADIOGRAPHY;

HARMINE ANALOG; IN-VITRO EVALUATION; LABELING STRATEGY; LABELINGS; METHOXY; MONOAMINE OXIDASE A; NUCLEOPHILIC 18F-FLUORINATION; ONE-STEP LABELING; Β-CARBOLINE; Β-CARBOLINE ALKALOID;

LIGANDS;

7 (2 FLUOROETHOXY) 1 METHYL 9H BETA CARBOLINE F 18; 7 (3 FLUOROPROPOXY) 1 METHYL 9H BETA CARBOLINE F 18; 7 [2 (2 FLUOROETHOXY)ETHOXY] 1 METHYL 9H BETA CARBOLINE F 18; 7 [2 [2 (2 FLUOROETHOXY)ETHOXY]ETHOXY] 1 METHYL 9H BETA CARBOLINE F 18; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; HARMINE; RADIOPHARMACEUTICAL AGENT;

ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME BINDING; IN VITRO STUDY; ISOTOPE LABELING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT;

RATTUS;

EID: 47049090600     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.1519     Document Type: Article

References (18)

1. R. H. F. Manske, The carboline alkaloids in The Alkaloids, Vol. VIII, Academic Press, New York, 1965, pp. 47-53 (Chapter 3).
2. T. J. Hagen, P. Skolnick, J. M. Cook, J. Med. Chem. 1987, 30, 750-753.
3. Y. Song, J. Wang, S. F. Teng, D. Kesuma, Y. Deng, J. Duan, J. H. Wang, R. Zhong-Qi, M. M. Sim, Bioorg. Med. Chem. Lett. 2002, 12, 1129-1132.
4. H. Kim, S. O. Sablin, R. R. Ramsay, Arch. Biochem. Biophys. 1997, 337, 137-142.
5. H. Blaschko, Rev. Physiol. Biochem. Pharmacol. 1974, 70, 83-148.
6. J. A. Fuentes, N. H. Neff, Neuropharmacology 1975, 14, 819-825.
7. M. Bergström, G. Westerberg, T. Kihlberg, B. Långström, Nucl. Med. Biol. 1997, 24, 381-388.
8. M. Bergström, G. Westerberg, G. Németh, M. Traut, G. Gross, G. Greger, H. Müller-Peltzer, A. Safer, S.-Å. Eckernäs, A. Grahnér, B. Långström, Eur. J. Clin. Pharmacol. 1997, 52, 121-128.
9. N. Ginovart, J. H. Meyer, A. Boovariwala, D. Hussey, E. A. Rabiner, S. Houle, A. A. Wilson, J. Cereb. Blood Plow Metab. 2006, 26, 330-344.
10. S. B. Jensen, A. K. Olsen, K. Pedersen, P. Cumming, Synapse 2006, 59, 427-434.
11. R. Murthy, K. Erlandsson, D. Kumar, R. Van Heertum, J. Mann, R. Parsey, Nucl. Med. Commun. 2007, 28, 748-754.
12. H. Örlefors, A. Sundin, K.-J. Fasth, K. Öberg, B. Långström, B. Eriksson, M. Bergström, Nucl. Med. Biol. 2003, 30, 669-679.
13. W. Zhang, S. Oya, M.-P. Kung, C. Hou, D. L. Maier, H. F. Kung, Nucl. Med. Biol. 2005, 32, 799-809.
14. M. Bergström, G. Westerberg, B. Långström, Nucl. Med. Biol. 1997, 24, 287-293.
15. J. Mukherjee, Z.-Y. Yang, Nucl. Med. Biol. 1999, 26, 619-625.
16. D. W. Kim, D.-S. Ahn, Y.-H. Oh, S. Lee, H. S. Kil, S. J. Oh, S. J. Lee, J. S. Kim, J. S. Ryu, D. H. Moon, D. Y. Chi, J. Am. Chem. Soc. 2006, 128, 16394-16397.
17. www.acdlabs.com.
18. P. Bjurling, R. Reineck, G. Westerberg, A. Gee, J. Sutcliffe, B. Långström, Presented at Proceedings of the VIth Workshop on Targetry and Target Chemistry, TRIUMF, Vancouver, Canada, 1995, pp. 282-284.