Spirulina platensis effects on the levels of total cholesterol, HDL and triacylglycerols in rabbits fed with a hypercholesterolemic diet

Brazilian Archives of Biology and Technology

Volumn 51, Issue 2, 2008, Pages 405-411

  Colla, Luciane Maria ^a   Muccillo Baisch, Ana Luiza ^b   Vieira Costa, Jorge Alberto ^c  

^a UNIVERSITY OF PASSO FUNDO   (Brazil)

^b Departamento de Ciências Fisiológicas

^c FEDERAL UNIVERSITY OF RIO GRANDE   (Brazil)

Author keywords

Cholesterol; Rabbits; Spirulina platensis

Indexed keywords

ANIMALIA; ORYCTOLAGUS CUNICULUS; SPIRULINA; SPIRULINA PLATENSIS;

EID: 46949103660     PISSN: 15168913     EISSN: 15168913     Source Type: Journal    
DOI: 10.1590/S1516-89132008000200022     Document Type: Article

References (36)

1. A.O.A.C. (1995). Official methods of analysis. 16. ed. Association of Official Analytical Chemists. Arlington.
2. Alonso D. and Maroto F. (2000), Plant as 'chemical factories' for the production of polyunsaturated fatty acids: Biotechnol. Adv. 18, 481-497.
3. Amaral, D.M.; Moreira, M.; Lobato, M.A.; Abreu, S.M. (1995), Efeito inibidor de substâncias antioxidantes existentes no vinho tinto na aterogênese experimental no coelho. Vittalle, 7, 17-24.
4. Becker, E.W.; Jakober, B.; Luft, D.; Schumuling, R.M.; (1986), Clinical and biochemical evaluations of the alga Spirulina with regard of its application in the treatment of obesity: Nutr. Rep. Int. 33, 565-574.
5. Belay, A.; Ota, Y.; Miyakawa, K.; Shimamatsu, H. (1993), Current knowledge on potential health benefits of Spirulina. Journal of Applied Phycology. 5, 235-241.
6. Bhat, V.B.; Madyastha, M. (2001), Scavenging of Peroxynitrite by phycocyanin and phycocyanobilin from Spirulina platensis: protection against oxidative damage to DNA: Biochemical and Biophysical Research Communications 285, 262-266.
7. Blé-Castillo, J.L.B.; Rodriguez-Hernandez, A.; Miranada-Zamora, R.; Juárez-Oropeza, M. A.; Díaz-Zagoya, J.C. (2002), Arthospira maxima prevents the acute fatty liver induced by the administration of simvastatin, ethanol and a hypercholesterolemic diet to mice. Life Sciences 70, 2665-2673.
8. Champe, P.C.; Harvey, R.A. (1997), Bioquímica ilustrada, 2. ed., Porto Alegre: Arles Médicas.
9. Cohen Z.; Reungjitchachawali M.; Angdung W.; Tanticharoen M. (1993), Production and partial purification of gamma-linolenic acid and some pigments from Spirulina platensis: J. Appl. Phycol. 5, 109-115.
10. Cohen Z.; Vonshak A.; Richmond A. (1987), Fatty acid composition of Spirulina strains grown under various environmental conditions. Phytochem.: 26 (8), 2255-2258.
11. Colla, L.M.; Bertolin, T.E.; Costa, J.A.V. (2004), Fatty acids profile of Spirulina platensis grown under different temperatures and nitrogen concentrations: Z. Naturforsch. C, 59, 55-59.
12. Estrada, J.E.P.; Bescós, P.B.; Villar del Fresno, A.M. (2001), Antioxidant activity of different fractions of Spirulina platensis protean extract: Il Farmaco 56, 497-500.
13. Gardner, P.T.; White, T.A.C.; McPhail, D.B.; Duthie, G.G. (2000), The relative contributions of vitamin C, carotenoids and phenolics to the antioxidant potential of fruit juices. Food Chemistry, 68, 471-474.
14. Gugliucci, A. (1996), Antioxidant effects of Ilex paraguariensis induction of decreased oxidability of human LDL in vivo. Biochemical and Biophysical Research Communications, 224 (2), 338-344.
15. Henrikson, R. (1994), Microalga Spirulina -Superalimento del futuro. Barcelona: Ediciones S.A. Urano, ISBN 84-7953-047-2.
16. Hill, S.A.; McQueen, M.J. (1997), Reverse cholesterol transport - a review of the process and its clinical implications. Clinical Biochemistry, 30 (7), 517-525.
17. Ishikawa T.; Fujiyama Y.; Igarashi C.; Morino M.; Fada N.; Kagami A.; Sakamoto T.; Nagano M.; Nakamura, H. (1989), Clinical features of familial hypercholesterolemia: Atherosclerosis, 75, 95-103.
18. Iwata, K.; Inayama, T.; Kato, T. (1987), Effects of Spirulina platensis on fructose-induced hyperlipidemia in rats. J. Jap. Soc. Nutr. Food Sci., 40, 463-467.
19. Kato, T.; Takemoto, K.; Katayama, H.; Kuwabara, Y. (1984), Effects of Spirulina (Spirulina platensis) on dietary hypercholesterolemia in rats. J. Jap. Soc. Nutr. Food Sci., 37, 323-332.
20. Kay, R. A. (1991), Microalgae as food and supplement: Crit. Rev. Food Sci. Nutr. 30, 555-573.
21. Keaney, J.F.; Gaziano, M.; Xu, A.; Frei, B.; Celentano, J.C. Shwaery, G.T., Loscalzo, J.; Vita, J. A. (1993), Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits: Proc. Nat. Acad. Sci 90, 11880-11884.
22. Kurushima, H.; Hayashi, K.; Shingu, T.; Kuga, Y.; Ohtani, H.; Okura, Y.; Tanaka, K.; Yasunobu, Y.; Nomura, K.; Kajiyama, G. (1995), Opposite effects on cholesterol metabolism and their mechanisms induced by dietary oleic acid and palmitic acid in hamsters. Biochimica et Biophysica Acta, v. 1258, 251-256.
23. Mahfouz, M.M.; Kawano, H.; Dummerow, F.A. (1997), Effect of cholesterol-rich diets with and without added vitamins E and C on the severity of atherosclerosis in rabbits: Am. J. Clin. Nutr. 66, 1240-1249.
24. Miranda, M.S.; Cintra, R.G.; Barros, S.B.M.; Filho, J.M. (1998), Antioxidant activity of the microalga Spirulina maxima. Brazilian Journal of Medical and Biological Research, 31, 1075-1079.
25. Nagaoka, S.; Shimizu, K.; Kaneko, H.; Shibayama, F.; Morikawa, K.; Kanamaru, Y.; Otsuka, A.; Hirahashi, T.; Kato, T. (2005). A novel protein C-phycocyanin plays a crucial role in the hypocholesterolemic action of Spirulina platensis concentrate in rats: Journal of Nutrition, 135, 2425-2430.
26. Nakaya, N.; Honma, Y.; Goto, Y. (1988), Cholesterol lowering effect of Spirulina. Nutr. Rep. Int., 37, 1329-1337.
27. Olguín E.; Galicia S.; Angulo-Guerrero O.; Hernández E. (2001), The effect of low light flux and nitrogen deficiency on the chemical composition of Spirulina sp. (Arthospira) grown on digested pig waste: Biores. Technol. 77, 19-24.
28. Perugini, C.; Bagnati, M.; Cau, C.; Bordone, R.; Zoppis, E.; Paffoni, P.; Re, R.; Albano, E.; Bellomo, G. (2000), Distribution of lipid-soluble antioxidants in lipoproteins from healthy subjects. Correlation with plasma antioxidant levels and composition of lipoproteins. Pharmacological Research, 41 (1), 55-65.
29. Quoc K.; Dubacq J.; Demandre C.; Mazliak P. (1994), Comparative effects of exogenous fatty acid supplementations on the lipids from the cyanobacterium Spirulina platensis: Plant Physiol. Biochem. 32, 501-509.
30. Ramamoorthy, A.; Premakumari, S. (1996), Effect of suplementation of Spirulina on hypercholesterolemic patients. J. Food Sci. Technol, 33 (2), 124-128.
31. Reddy, M.C.; Subhashini, J.; Mahipal, S.V.K.; Bhat, V.B.; Reddy, P.S.; Kiranmai, G.; Madyastha, K.M.; Reddanna, P. (2003). C-phycocyanin, a selective cyclooxigenase-2 inhibitor, induces apoptosis in lipopolysaccharide-stimulated RAW 264.7 macrophages. Biochemical and Biophysical Research Communications 304, 385-392.
32. Renaud, S.; Lorgeril, M. (1992), Wine, alcohol, platelets, and the French paradox for coronary heart disease. The Lancet, 1523-1526.
33. Schinella, G.R.; Troiani, G.; Dávila, V.; de Buschiazzo, P.M.; Tournier, H.A. (2000), Antioxidant effects of an aqueous extract of Ilex paraguariensis. Biochemical and Biophysical Research Communications, 269 (2), 357-360.
34. 99m TC-β-VLDL in rabbits: Brazilian Journal of Medical and Biological Resesarch 30, 705-717.
35. Stryer, L. (1996), Bioquímica, 4. ed., Stanford University, Rio de Janeiro: Guanabara Koogan. ISBN 0-7167-3687-X.
36. Torres-Durán, P.V.; Miranda-Zamora, R.; Paredes-Carbajal, M.C.; Masher, D.; Blé-Castillo, J.; Díaz-Zagoya, J.C.; Juárez-Oropeza, M.A. (1999), Studies on the preventive effect of Spirulina maxima on fatty liver development induced by carbon tetrachloride, in the rat: Journal of Ethnopharmacology 64, 141-147.