Targeting of the small GTPase Rap2b, but not Rap1b, to lipid rafts is promoted by palmitoylation at Cys176 and Cys177 and is required for efficient protein activation in human platelets

Cellular Signalling

Volumn 20, Issue 9, 2008, Pages 1662-1670

  Canobbio, Ilaria ^a   Trionfini, Piera ^a   Guidetti, Gianni F ^a   Balduini, Cesare ^a   Torti, Mauro ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

Human platelets; Lipid rafts; Palmitoylation; Platelet aggregation; Rap1b; Rap2b

Indexed keywords

CYSTEINE; GUANOSINE TRIPHOSPHATASE; RAP PROTEIN; RAP1 PROTEIN; RAP1B PROTEIN; RAP2B PROTEIN; SERINE;

AMINO ACID SUBSTITUTION; ARTICLE; CELL STIMULATION; CELL STRAIN HEK293; ENZYME ACTIVATION; GENE DELETION; HUMAN; HUMAN CELL; LIPID RAFT; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE AGGREGATION INHIBITION;

AMINO ACID SEQUENCE; BLOOD PLATELETS; CELL LINE; CHOLESTEROL; CYSTEINE; DETERGENTS; ENZYME ACTIVATION; HUMANS; LIPOYLATION; MEMBRANE MICRODOMAINS; MOLECULAR SEQUENCE DATA; MONOMERIC GTP-BINDING PROTEINS; PLATELET ACTIVATION; PROTEIN TRANSPORT; RAP GTP-BINDING PROTEINS; SUBCELLULAR FRACTIONS;

EID: 46849119837     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2008.05.016     Document Type: Article

References (38)

1. Ehrhardt A., Ehrhardt G.R., Guo X., and Schrader J.W. Exp. Hematol. 30 (2002) 1089-1106
2. Paganini S., Guidetti G.F., Catricalà S., Trionfini P., Panelli S., Balduini C., and Torti M. Biochimie 88 (2006) 285-295
3. Torti M., and Lapetina E.G. Thromb. Haemost. 71 (1994) 533-543
4. Bos J.L., de Bruyn K., Enserink J., Kuiperij B., Rangarajan S., Rehmann H., Riedl J., de Rooij J., van Mansfeld F., and Zwartkruis F. Biochem. Soc. Trans. 31 (2003) 83-86
5. Bertoni A., Tadokoro S., Eto K., Pampori N., Parise L.V., White G.C., and Shattil S.J. J. Biol. Chem. 277 (2002) 25715-25721
6. Chrzanowska-Wodnicka M., Smyth S.S., Schoenwaelder S.M., Fischer T.H., and 2nd White G.C. J. Clin. Invest. 115 (2005) 680-687
7. Bernardi B., Guidetti G.F., Campus F., Crittenden J.R., Graybiel A.M., Balduini C., and Torti M. Blood 107 (2006) 2728-2735
8. McLeod S.J., Shum A.J., Lee R.L., Takei F., and Gold M.R. J. Biol. Chem. 279 (2004) 12009-12019
9. Lerosey I., Pizon V., Tavitian A., and de Gunzburg J. Biochem. Biophys. Res. Commun. 175 (1991) 430-436
10. Kitayama H., Sugimoto Y., Matsuzaki T., Ikawa Y., and Noda M. Cell 56 (1989) 77-84
11. Jimenez B., Pizon V., Lerosey I., Beranger F., Tavitian A., and de Gunzburg J. Int. J. Cancer 49 (1991) 471-479
12. Stope M.B., Vom Dorp F., Szatkowski D., Bohm A., Keiper M., Nolte J., Oude Weernink P.A., Rosskopf D., Evellin S., Jakobs K.H., and Schmidt M. Mol. Cell Biol. 24 (2004) 4664-4676
13. Greco F., Sinigaglia F., Balduini C., and Torti M. J. Thromb. Haemost. 2 (2004) 2223-2230
14. Kawata M., Farnsworth C.C., Yoshida Y., Gelb M.H., Glomset J.A., and Takai Y. Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 8960-8964
15. Farrell F.X., Yamamoto K., and Lapetina E.G. Biochem. J. 289 (1993) 349-355
16. Akbar U., Winegar D.A., and Lapetina E.G. J. Biol. Chem. 266 (1991) 4387-4391
17. Willumsen B.M., Christensen A., Hubbert N.L., Papageorge A.G., and Lowy D.R. Nature 310 (1984) 583-586
18. Hancock J.F., Paterson H., and Marshall C.J. Cell 63 (1990) 133-139
19. Hancock J.F., Magee A.I., Childs J.E., and Marshall C.J. Cell 57 (1989) 1167-1177
20. Prior I.A., and Hancock J.F. J. Cell Sci. 114 (2001) 1603-1608
21. Hancock J.F. Nat. Rev., Mol. Cell. Biol. 4 (2003) 373-384
22. Pike L.J. Biochem. J. 378 (2004) 281-292
23. Hoessli D.C., Ilangumaran S., Soltermann A., Robinson P.J., Borisch B., and Nasir-Ud-Din. Glycoconj. J. 17 (2000) 191-197
24. Gousset K., Wolkers W.F., Tsvetkova N.M., Oliver A.E., Field C.L., Walker N.J., Crowe J.H., and Tablin F. J. Cell. Physiol. 190 (2002) 117-128
25. Bodin S., Tronchere H., and Payrastre B. Biochim. Biophys. Acta 1610 (2003) 247-257
26. Locke D., Chen H., Liu Y., Liu C., and Kahn M.L. J. Biol. Chem. 277 (2002) 18801-18809
27. Ezumi Y., Kodama K., Uchiyama T., and Takayama H. Blood 99 (2002) 3250-3255
28. Shrimpton C.N., Borthakur G., Larrucea S., Cruz M.A., Dong J.F., and Lopez J.A. J. Exp. Med. 196 (2002) 1057-1066
29. Bodin S., Viala C., Ragab A., and Payrastre B. Thromb Haemost. 89 (2003) 318-330
30. Sardjono C.T., Harbour S.N., Yip J.C., Paddock C., Tridandapani S., Newman P.J., and Jackson D.E. Thromb. Haemost. 96 (2006) 756-766
31. Dorahy D.J., and Burns G.F. Biochem. J. 333 (1998) 373-379
32. Wonerow P., Obergfell A., Wilde J.I., Bobe R., Asazuma N., Brdicka T., Leo A., Schraven B., Horejsi V., Shattil S.J., and Watson S.P. Biochem. J. 364 (2002) 755-765
33. Canobbio I., Stefanini L., Guidetti G.F., Balduini C., and Torti M. Cell Signal. 18 (2006) 861-870
34. Ramaschi G., Torti M., Tolnai Festetics E., Sinigaglia F., Malavasi F., and Balduini C. Blood 87 (1996) 2308-2313
35. Zhang W., Trible R.P., and Samelson L.E. Immunity 9 (1998) 239-246
36. Beranger F., Tavitian A., and de Gunzburg J. Oncogene 6 (1991) 1835-1842
37. Linder M.E., and Deschenes R.J. J. Cell Sci. 117 (2004) 521-526
38. Kilsdonk E.P., Yancey P.G., Stoudt G.W., Bangerter F.W., Johnson W.J., Phillips M.C., and Rothblat G.H. J. Biol. Chem. 270 (1995) 17250-17256