Kaempferol, but not resveratrol inhibits angiotensin converting enzyme

Journal of Physiology and Pharmacology

Volumn 59, Issue 2, 2008, Pages 387-392

  Olszanecki, Rafal ^a,b   Bujak Gizycka, B ^a   Madej, J ^a   Suski, M ^a   Wolkow P P ^a   Jawien J ^a   Korbut, R ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b Department of Pharmacology ^*  (Poland)

Author keywords

ACE inhibitors (ACEi); Angiotensin converting enzyme (ACE); Flavonoids; French wine; Hypertension; Resveratrol

Indexed keywords

ANGIOTENSIN I; ANGIOTENSIN II; DIPEPTIDYL CARBOXYPEPTIDASE; FLAVONOID; KAEMPFEROL; PERINDOPRILAT; RESVERATROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; ENZYME INHIBITION; HYPERTENSION; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; RAT; WINE; WISTAR KYOTO RAT;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; KAEMPFEROLS; MALE; PEPTIDYL-DIPEPTIDASE A; RATS; RATS, INBRED WKY; STILBENES;

EID: 46849104289     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Atlas SA. The renin-angiotensin aldosterone system: pathophysiological role and pharmacologic inhibition. J Manag Care Pharm 2007; 13(8 Suppl B): 9-20.
2. Kramkowski K, Mogielnicki A, Buczko W. The physiological significance of the alternative pathways of angiotensin II production. J Physiol Pharmacol 2006; 57: 529-539.
3. Wong J, Patel RA, Kowey PR. The clinical use of angiotensin-converting enzyme inhibitors. Prog Cardiovasc Dis 2004; 47: 116-130.
4. Ross JA, Kasum CM. Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr 2002; 22: 19-34.
5. Ryszawa N, Kawczynska-Drozdz A, Pryjma J, et al. Effects of novel plant antioxidants on platelet superoxide production and aggregation in atherosclerosis. J Physiol Pharmacol 2006; 57: 611-626.
6. Dell'Agli M, Busciala A, Bosisio E. Vascular effects of wine polyphenols. Cardiovasc Res 2004; 63: 593-602.
7. Olszanecki R, Gebska A, Kozlovski VI, Gryglewski RJ. Flavonoids and nitric oxide synthase. J Physiol Pharmacol 2002; 53(4 Pt 1): 571-584.
8. Graf BA, Milbury PE, Blumberg JB. Flavonols, flavones, flavanones, and human health: epidemiological evidence. J Med Food 2005; 8: 281-290.
9. Pervaiz S. Resveratrol: from grapevines to mammalian biology. FASEB J 2003; 17:1975-1985.
10. Bujak-Gizycka B, Madej J, Wolkow PP, et al. Measurement of angiotensin metabolites in organ bath and cell culture experiments by liquid chromatography - electrospray ionization - mass spectrometry (LC-ESI-MS). J Physiol Pharmacol 2007; 58: 529-540.
11. Cui L, Nithipatikom K, Campbell WB. Simultaneous analysis of angiotensin peptides by LC-MS and LC-MS/MS: metabolism by bovine adrenal endothelial cells. Anal Biochem 2007; 369: 27-33.
12. Actis-Goretta L, Ottaviani JI, Keen CL, Fraga CG. Inhibition of angiotensin converting enzyme (ACE) activity by flavan-3-ols and procyanidins. FEBS Lett 2003; 555: 597-600.
13. Ottaviani JI, Actis-Goretta L, Villordo JJ, Fraga CG. Procyanidin structure defines the extent and specificity of angiotensin I converting enzyme inhibition. Biochimie 2006; 88:359-365.
14. Loizzo MR, Said A, Tundis R, et al. Inhibition of angiotensin converting enzyme (ACE) by flavonoids isolated from Ailanthus excelsa (Roxb) (Simaroubaceae). Phytother Res 2007; 21: 32-36.
15. Oh H, Kang DG, Kwon JW, et al. Isolation of angiotensin converting enzyme (ACE) inhibitory flavonoids from Sedum sarmentosum. Biol Pharm Bull 2004; 27: 2035-2037.
16. Persson IA, Josefsson M, Persson K, Andersson RG. Tea flavanols inhibit angiotensin-converting enzyme activity and increase nitric oxide production in human endothelial cells. J Pharm Pharmacol 2006; 58: 1139-1144.
17. Bormann H, Melzig MF. Inhibition of metallopeptidases by flavonoids and related compounds. Pharmazie 2000; 55: 129-132.
18. Uchida S, Ikari N, Ohta H, et al. Inhibitory effects of condensed tannins on angiotensin converting enzyme. Jpn J Pharmacol 1987; 43: 242-246.
19. Scalbert A, Johnson IT, Saltmarsh M. Polyphenols: antioxidants and beyond. Am J Clin Nutr 2005; 81(1 Suppl): 215S-217S.