A randomized, double-blind study of valsartan versus metoprolol on arterial distensibility and endothelial function in essential hypertension

Nephrology Dialysis Transplantation

Volumn 23, Issue 7, 2008, Pages 2280-2285

  Kosch, Markus ^a   Levers, Andrea ^a   Lang, Detlef ^a   Bartels, Valerie ^a   Rahn, Karl Heinz ^a   Pavenstädt, Hermann ^a   Hausberg, Martin ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Arterial distensibility and compliance; AT1 receptor blocker; Endothelial function; Essential hypertension; Intima media thickness

Indexed keywords

HYDROCHLOROTHIAZIDE; METOPROLOL; VALSARTAN;

ADD ON THERAPY; ADRENERGIC STIMULATION; ADULT; ARTERY COMPLIANCE; ARTICLE; BLOOD PRESSURE MEASUREMENT; BRACHIAL ARTERY; CAROTID ARTERY; CLINICAL TRIAL; COLD PRESSOR TEST; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ESSENTIAL HYPERTENSION; FEMALE; HUMAN; INTIMA; MAJOR CLINICAL STUDY; MALE; PARAMETER; PRIORITY JOURNAL; PULSE WAVE; RANDOMIZED CONTROLLED TRIAL; REST; SHORT COURSE THERAPY; THICKNESS; TUNICA MEDIA; VASCULAR ENDOTHELIUM; YOUNG MODULUS;

ADULT; ANTIHYPERTENSIVE AGENTS; BLOOD FLOW VELOCITY; BLOOD PRESSURE; BRACHIAL ARTERY; CAROTID ARTERIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ELASTICITY; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; HYPERTENSION; MALE; METOPROLOL; MIDDLE AGED; SYMPATHETIC NERVOUS SYSTEM; TETRAZOLES; TUNICA INTIMA; TUNICA MEDIA; VALINE;

EID: 46849094515     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfm936     Document Type: Article

References (25)

1. Panza JA, Quyyumi AA, Brush JE Jr et al. Abnormal endothelium dependent vascular relaxation in patients with essential hypertension. N Engl J Med 1990; 323: 22-27
2. Panza JA, Casino PR, Kilcoyne CM et al. Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension. Circulation 1993; 87: 1468-1474
3. Brush JE Jr, Faxon DP, Salmon S et al. Abnormal endothelium-dependent coronary vasomotion in hypertensive patients. J Am Coll Cardiol 1992; 19: 809-815
4. Tonkin AL, Wing LMH. Effects of age and isolated systolic hypertension on cardiovascular reflexes. J Hypertens 1994; 12: 1083-1088
5. Safar ME, Levy BI, Laurent S et al. Hypertension and the arterial system: clinical and therapeutic aspects. J Hypertens 1990; 8(Suppl 7): S113-S119
6. Rizzoni D, Muiesan ML, Porteri E et al. Effects of long-term antihypertensive treatment with lisinopril on resistance arteries in hypertensive patients with left ventricular hypertrophy. J Hypertens 1997; 15: 197-204
7. Schiffrin EL. Vascular and cardiac benefits of angiotensin receptor blockers. Am J Med 2002; 113: 409-418
8. Antony I, Lerebours G, Nitenberg A. Angiotensin-converting enzyme inhibition restores flow-dependent and cold pressure test induced dilations in coronary arteries of hypertensive patients. Circulation 1996; 94: 3115-3122
9. Creager MA, Roddy MA. Effect of captopril and enalapril on endothelial function in hypertensive patients. Hypertension 1994; 24: 499-505
10. Taddei S, Virdis A, Ghiadoni L et al. Effects of angiotensin converting enzyme inhibition on endothelium-dependent vasodilatation in essential hypertensive patients. J Hypertens 1998; 16: 447-456
11. Schiffrin EL, Park JB, Intengan HD et al. Correction of arterial structure and endothelial dysfunction in human essential hypertension by the angiotensin receptor antagonist losartan. Circulation 2000; 101: 1653-1659
12. Kosch M, Barenbrock M, Kisters K et al. Relation between muscle sympathetic nerve activity and large artery mechanical vessel wall properties in renal transplant patients. J Hypertens 2002; 20: 501-508
13. Wilkinson IB, Franklin SS, Cockcroft JR. Nitric oxide and the regulation of large artery stiffness. Hypertension 2004; 44: 112-116
14. Hausberg M, Kosch M, Stam F et al. Effect of fluvastatin on endothelium-dependent brachial artery vasodilation in patients after renal transplantation. Kidney Int 2001; 59: 1473-1479
15. Kosch M, Hausberg M, Suwelack M. Studies on effects of calcineurin inhibitor withdrawal on arterial distensibility and endothelial function in renal transplant recipient. Transplantation 2003; 76: 1516-1519
16. Kosch M, Levers A, Barenbrock M et al. Acute effects of hemodialysis on endothelial function and large artery elasticity. Nephrol Dial Transplant 2001; 16: 1663-1668
17. Kosch M, Barenbrock M, Hausberg M et al. Arterial distensibility and pulse wave velocity in patients with primary hyperparathyroidism before and after parathyroidectomy. Clin Neph 2001; 55: 303-308
18. Ghiadoni L, Virdis A, Magagna A et al. Effect of the angiotensin II type 1 receptor blocker candesartan on endothelial function in patients with essential hypertension. Hypertension 2000; 35: 501-506
19. Prasad A, Tupas-Habib T, Schenke WH et al. Acute and chronic angiotensin-1 receptor antagonism reverses endothelial dysfunction in atherosclerosis. Circulation 2000; 101: 2349-2354
20. Park JB, Intengan HD, Schiffrin EL. Reduction of resistance artery stiffness by treatment with the AT1-receptor antagonist losartan in essential hypertension. J Renin Angiotensin Aldosterone Syst 2000; 1: 40-45
21. von zur Mühlen B, Kahan T, Hagg A et al. Treatment with irbesartan or atenolol improves endothelial function in essential hypertension. J Hypertens 2001; 19: 1813-1818
22. Kiowski W, Linder L, Nuesch R et al. Effect of cilazapril on vascular structure and function in essential hypertension. Hypertension 1996; 27: 371-376
23. Schiffrin EL, Park JB, Pu Q. Effect of crossing over hypertensive patients from a beta-blocker to an angiotensin receptor antagonist on resistance artery structure and on endothelial function. J Hypertens 2002; 20: 71-78
24. Anderson TJ, Elstein E, Haber H et al. Comparative study of ACE-inhibition, angiotensin II antagonism, and calcium channel blockade on flow-mediated vasodilatation in patients with coronary disease (BANFF Study). J Am Coll Cardiol 2000; 35: 60-66
25. Klingbeil A, John S, Schneider MP et al. Effect of AT1 receptor blockade on endothelial function in essential hypertension. Am J Hypertens 2003; 16: 123-128