Axonal loss in the retinal nerve fiber layer in patients with multiple sclerosis

Multiple Sclerosis

Volumn 14, Issue 5, 2008, Pages 609-614

  Pueyo, Victoria ^a,b   Martin, J ^a   Fernandez, J ^a   Almarcegui, C ^a   Ara, J ^a   Egea, C ^a   Pablo, L ^a   Honrubia, F ^a  

^a Isabel la Catolica   (Spain)

^b NONE   (Spain)

Author keywords

Axonal loss; Multiple sclerosis; Relapsing remitting

Indexed keywords

ADULT; ANALYSIS OF VARIANCE; ARTICLE; CELL LOSS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS-SECTIONAL STUDY; DISEASE DURATION; EVOKED VISUAL RESPONSE; EXPANDED DISABILITY STATUS SCALE; FEMALE; FUNCTIONAL ASSESSMENT; HUMAN; MALE; MULTIPLE SCLEROSIS; NEUROLOGIC EXAMINATION; OPTIC NERVE; OPTIC NEURITIS; OPTICAL COHERENCE TOMOGRAPHY; POLARIMETRY; QUANTITATIVE ANALYSIS; RETINA NERVE CELL; THICKNESS; VISUAL ACUITY; VISUAL FIELD; VISUAL SYSTEM EXAMINATION;

ADULT; AXONS; CROSS-SECTIONAL STUDIES; DIAGNOSTIC TECHNIQUES, OPHTHALMOLOGICAL; DISABILITY EVALUATION; EVOKED POTENTIALS, VISUAL; FEMALE; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; OPTIC NERVE; OPTIC NEURITIS; RETINA; TOMOGRAPHY, OPTICAL COHERENCE; VISUAL ACUITY;

EID: 46849088970     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/1352458507087326     Document Type: Article

References (36)

1. Hauser, SL, Oksenberg, JR. The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. Neuron 2006; 52: 61-76.
2. Imitola, J, Chitnis, T, Khoury, SJ. Insights into the molecular pathogenesis of progression in multiple sclerosis: potential implications for future therapies. Arch Neurol 2006; 63: 25-33.
3. Smith, KJ, Kapoor, R, Hall, SM, Davies, M. Electrically active axons degenerate when exposed to nitric oxide. Ann Neurol 2001; 49: 470-476.
4. Brosnan, CF, Battistini, L, Raine, CS, Dickson, DW, Casadevall, A, Lee, SC. Reactive nitrogen intermediates in human neuropathology: an overview. Dev Neurosci 1994; 16: 152-161.
5. McDonald, WI, Barnes, D. The ocular manifestations of multiple sclerosis. 1. Abnormalities of the afferent visual system. J Neurol Neurosurg Psychiatty 1992; 55: 747-752.
6. Jaffe, GJ, Caprioli, J. Optical coherence tomography to detect and manage retinal disease and glaucoma. Am J Ophthalmol 2004; 137: 156-169.
7. Paunescu, LA, Schuman, JS, Price, LL, Stark, PC, Beaton, S, Ishikawa, H, et al. Reproducibility of nerve fiber thickness, macular thickness, and optic nerve head measurements using StratusOCT. Invest Ophthalmol Vis Sci 2004; 45: 1716-1724.
8. Weinreb, RN, Shakiba, S, Zangwill, L. Scanning laser polarimetry to measure the nerve fiber layer of normal and glaucomatous eyes. Am J Ophthalmol 1995; 119: 627-636.
9. Costello, F, Coupland, S, Hodge, W, Lorello, GR, Koroluk, J, Pan, YI, et al. Quantifying axonal loss after optic neuritis with optical coherence tomography. Ann Neurol 2006; 59: 963-969.
10. Danesh-Meyer, HV, Carroll, SC, Ku, JY, Hsiang, J, Gaskin, B, Gamble, GG, et al. Correlation of retinal nerve fiber layer measured by scanning laser polarimeter to visual field in ischemic optic neuropathy. Arch Ophthalmol 2006; 124: 1720-1726.
11. Steel, DH, Waldock, A. Measurement of the retinal nerve fibre layer with scanning laser polarimetry in patients with previous demyelinating optic neuritis. J Neurol Neurosurg Psychiatry 1998; 64: 505-509.
12. Poser, CM, Paty, DW, Scheinberg, L, McDonald, WI, Davis, FA, Ebers, GC, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983; 13: 227-231.
13. Huang, D, Swanson, EA, Lin, CP, Schuman, JS, Stinson, WG, Chang, W, et al. Optical coherence tomography. Science 1991; 254: 1178-1181.
14. Celesia, GG, Bodis-Wollner, I, Chatrian, GE, Harding, GF, Sokol, S, Spekreijse, H. Recommended standards for electroretinograms and visual evoked potentials. Report of an IFCN committee. Electroencephalogr Clin Neurophysiol 1993; 87: 421-436.
15. Kalkers, NF, Bergers, E, Castelijns, JA, van Walderveen, MA, Bot, JC, Ader, HJ, et al. Optimizing the association between disability and biological markers in MS. Neurology 2001; 57: 1253-1258.
16. Trapp, BD, Peterson, J, Ransohoff, RM, Rudick, R, Mork, S, Bo, L. Axonal transection in the lesions of multiple sclerosis. New Engl J Med 1998; 338: 278-285.
17. Frohman, E, Costello, F, Zivadinov, R, Stuve, O, Conger, A, Winslow, H, et al. Optical coherence tomography in multiple sclerosis. Lancet Neurol 2006; 5: 853-863.
18. Frisen, L, Hoyt, WF. Insidious atrophy of retinal nerve fibers in multiple sclerosis. Funduscopic identification in patients with and without visual complaints. Arch Ophthalmol 1974; 92: 91-97.
19. Elbol, P, Work, K. Retinal nerve fiber layer in multiple sclerosis. Acta Ophthalmol (Copenh) 1990; 68: 481-486.
20. Honrubia, F, Calonge, B. Evaluation of the nerve fiber layer and peripapillary atrophy in ocular hypertension. Int Ophthalmol 1989; 13: 57-62.
21. Quigley, HA, Addicks, EM. Quantitative studies of retinal nerve fiber layer defects. Arch Ophthalmol 1982; 100: 807-814.
22. Funaki, S, Shirakashi, M, Funaki, H, Yaoeda, K, Abe, H. Relationship between age and the thickness of the retinal nerve fiber layer in normal subjects. Jpn J Ophthalmol 1999; 43: 180-185.
23. Budenz, DL, Anderson, DR, Varma, R, Schuman, J, Cantor, L, Savell, J, et al. Determinants of normal retinal nerve fiber layer thickness measured by stratus OCT. Ophthalmology 2007; 114: 1046-1052.
24. Jones, SJ. Visual evoked potentials after optic neuritis. Effect of time interval, age and disease dissemination. J Neurol 1993; 240: 489-494.
25. Trip, SA, Schlottmann, PG, Jones, SJ, Garway-Heath, DF, Thompson, AJ, Plant, GT, et al. Quantification of optic nerve head topography in optic neuritis: a pilot study. Br J Ophthalmol 2006; 90: 1128-1131.
26. Trip, SA, Schlottmann, PG, Jones, SJ, Altmann, DR, Garway-Heath, DF, Thompson, AJ, et al. Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis. Ann Neurol 2005; 58: 383-391.
27. Monteiro, ML, Medeiros, FA, Ostroscki, MR. Quantitative analysis of axonal loss in band atrophy of the optic nerve using scanning laser polarimetry. Br J Ophthalmol 2003; 87: 32-37.
28. Della, MG, Bacchetti, S, Zeppieri, M, Brusini, P, Cutuli, D, Gigli, GL. Nerve fibre layer analysis with GDx with a variable corneal compensator in patients with multiple sclerosis. Ophthalmologica 2007; 22: 186-189.
29. Banks, MC, Robe-Collignon, NJ, Rizzo, JF, Pasquale, LR. Scanning laser polarimetry of edematous and atrophic optic nerve heads. Arch Ophthalmol 2003; 121: 484-490.
30. Halliday, AM. Visual evoked potentials in demyelinating disease. Adv Neurol 1981; 31: 201-215.
31. Weinstock-Guttman, B, Baier, M, Stockton, R, Weinstock, A, Justinger, T, Munschauer, F, et al. Pattern reversal visual evoked potentials as a measure of visual pathway pathology in multiple sclerosis. Mult Scler 2003; 9: 529-534.
32. Parisi, V, Manni, G, Spadaro, M, Colacino, G, Restuccia, R, Marchi, S, et al. Correlation between morphological and functional retinal impairment in multiple sclerosis patients. Invest Ophthalmol Vis Sci 1999; 40: 2520-2527.
33. Ferguson, B, Matyszak, MK, Esiri, MM, Perry, VH. Axonal damage in acute multiple sclerosis lesions. Brain 1997; 120: 393-399.
34. Losseff, NA, Wang, L, Lai, HM, Yoo, DS, Gawne-Cain, ML, McDonald, WI, et al. Progressive cerebral atrophy in multiple sclerosis. A serial MRI study. Brain 1996; 119: 2009-2019.
35. Sepulcre, J, Murie-Fernandez, M, Salinas-Alaman, A, Garcia-Layana, A, Bejarano, B, Villoslada, P. Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS. Neurology 2007; 68: 1488-1494.
36. Fisher, JB, Jacobs, DA, Markowitz, CE, Galetta, SL, Volpe, NJ, Nano-Schiavi, ML, et al. Relation of visual function to retinal nerve fiber layer thickness in multiple sclerosis. Ophthalmology 113; 324-332.