Association of interleukin-6 (- 174G>C) promoter polymorphism with risk of squamous cell esophageal cancer and tumor location: An exploratory study

Clinical Immunology

Volumn 128, Issue 2, 2008, Pages 199-204

  Upadhyay, Rohit ^a   Jain, Meenu ^a   Kumar, Shaleen ^a   Ghoshal, Uday Chand ^a   Mittal, Balraj ^a  

^a SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Cancer risk; Cancer susceptibility; Esophageal cancer; Inflammation; Interleukin 6 gene polymorphism

Indexed keywords

INTERLEUKIN 6;

ADULT; AGED; ARTICLE; CANCER LOCALIZATION; CANCER RISK; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CONTROLLED STUDY; DNA POLYMORPHISM; ENVIRONMENTAL FACTOR; ESOPHAGUS CANCER; FEMALE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; METASTASIS; PRIORITY JOURNAL; PROTEIN FUNCTION; SQUAMOUS CELL CARCINOMA;

ADENOCARCINOMA; CARCINOMA, SQUAMOUS CELL; ESOPHAGEAL NEOPLASMS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; NEOPLASM METASTASIS; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); RISK FACTORS;

EID: 46749154982     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2008.03.519     Document Type: Article

References (30)

1. Layke J.C., and Lopez P.P. Esophageal cancer: a review and update. Am. Fam. Phys. 73 (2006) 2187-2194
2. Gallo A., and Cha C. Updates on esophageal and gastric cancers. World J. Gastroenterol. 12 (2006) 3237-3242
3. Kotnis A., Sarin R., and Mulherkar R. Genotype, phenotype and cancer: role of low penetrance genes and environment in tumour susceptibility. J. Biosci. 30 (2005) 93-102
4. Balkwill F., and Mantovani A. Inflammation and cancer: back to Virchow?. Lancet 357 (2001) 539-545
5. Boulanger M.J., Chow D.C., Brevnova E.E., and Garcia K.C. Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Science 300 (2003) 2101-2104
6. Diehl S., and Rincón M. The two faces of IL-6 on Th1/Th2 differentiation. Mol. Immunol. 39 (2002) 531-536
7. Asschert J.G., Vellenga E., Ruiters M.H., and de Vries E.G. Regulation of spontaneous and TNF/IFN-induced IL-6 expression in two human ovarian-carcinoma cell lines. Int. J. Cancer 82 (1999) 244-249
8. Fishman D., Faulds G., Jeffery R., Mohamed-Ali V., Yudkin J.S., Humphries S., and Woo P. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J. Clin. Invest. 102 (1998) 1369-1376
9. Oka M., Yamamoto K., Takahashi M., Hakozaki M., Abe T., Iizuka N., Hazama S., Hirazawa K., Hayashi H., Tangoku A., Hirose K., Ishihara T., and Suzuki T. Relationship between serum levels of interleukin 6, various disease parameters and malnutrition in patients with esophageal squamous cell carcinoma. Cancer Res. 56 (1996) 2776-7270
10. Wang L.S., Chow K.C., and Wu C.W. Expression and up-regulation of interleukin-6 in oesophageal carcinoma cells by n-sodium butyrate. Br. J. Cancer 80 (1999) 1617-1622
11. Fernández-Real J.M., Broch M., Vendrell J., Richart C., and Ricart W. Interleukin-6 gene polymorphism and lipid abnormalities in healthy subjects. J. Clin. Endocrinol. Metab. 85 (2000) 1334-1339
12. Foster C.B., Lehrnbecher T., Samuels S., Stein S., Mol F., Metcalf J.A., Wyvill K., Steinberg S.M., Kovacs J., Blauvelt A., Yarchoan R., and Chanock S.J. An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus. Blood 96 (2000) 2562-2567
13. Belluco C., Olivieri F., Bonafè M., Giovagnetti S., Mammano E., Scalerta R., Ambrosi A., Franceschi C., Nitti D., and Lise M. - 174 G>C polymorphism of interleukin 6 gene promoter affects interleukin 6 serum level in patients with colorectal cancer. Clin. Cancer Res. 9 (2003) 2173-2176
14. Hefler L.A., Grimm C., Ackermann S., Malur S., Radjabi-Rahat A.R., Leodolter S., Beckmann M.W., Zeillinger R., Koelbl H., and Tempfer C.B. An interleukin-6 gene promoter polymorphism influences the biological phenotype of ovarian cancer. Cancer Res. 63 (2003) 3066-3068
15. Cozen W., Gill P.S., Ingles S.A., Masood R., Martínez-Maza O., Cockburn M.G., Gauderman W.J., Pike M.C., Bernstein L., Nathwani B.N., Salam M.T., Danley K.L., Wang W., Gage J., Gundell-Miller S., and Mack T.M. IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma. Blood 103 (2004) 3216-3221
16. Campa D., Zienolddiny S., Maggini V., Skaug V., Haugen A., and Canzian F. Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer. Carcinogenesis 25 (2004) 229-235
17. Tan D., Wu X., Hou M., Lee S.O., Lou W., Wang J., Janarthan B., Nallapareddy S., Trump D.L., and Gao A.C. Interleukin-6 polymorphism is associated with more aggressive prostate cancer. J. Urol. 174 (2005) 753-756
18. Libra M., Signorelli S.S., Bevelacqua Y., Navolanic P.M., Bevelacqua V., Polesel J., Talamini R., Stivala F., Mazzarino M.C., and Malaponte G. Analysis of G(- 174)C IL-6 polymorphism and plasma concentrations of inflammatory markers in patients with type 2 diabetes and peripheral arterial disease. J. Clin. Pathol. 59 (2006) 211-215
19. Savage S.A., Abnet C.C., Haque K., Mark S.D., Qiao Y.L., Dong Z.W., Dawsey S.M., Taylor P.R., and Chanock S.J. Polymorphisms in interleukin -2, -6, and -10 are not associated with gastric cardia or esophageal cancer in a high-risk Chinese population. Cancer Epidemiol. Biomark. Prev. 13 (2004) 1547-1549
20. Jain M., Kumar S., Lal P., Tiwari A., Ghoshal U.C., and Mittal B. Role of GSTM3 polymorphism in the risk of developing esophageal cancer. Cancer Epidemiol. Biomark. Prev. 16 (2007) 178-181
21. Miller S.A., Dykes D.D., and Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16 (1988) 215
22. Ye S., Dhillon S., Ke X., Collins A.R., and Day I.N. An efficient procedure for genotyping single nucleotide polymorphisms. Nucleic Acids Res. 29 (2001) E88
23. Jain M., Kumar S., Rastogi N., Lal P., Ghoshal U.C., Tiwari A., Pant M.C., Baiq M.Q., and Mittal B. GSTT1, GSTM1 and GSTP1 genetic polymorphisms and interaction with tobacco, alcohol and occupational exposure in esophageal cancer patients from North India. Cancer Lett. 242 (2006) 60-67
24. Kaur G., Rapthap C.C., Kumar N., Kumar S., Neolia S., and Mehra N.K. Frequency distribution of cytokine gene polymorphisms in the healthy North Indian population. Tissue Antigens 69 (2007) 113-120
25. Lim C.S., Zheng S., Kim Y.S., Ahn C., Han J.S., Kim S., Lee J.S., and Chae D.W. The - 174 G to C polymorphism of interleukin-6 gene is very rare in Koreans. Cytokine 19 (2002) 52-54
26. Zhai R., Liu G., Yang C., Huang C., Wu C., and Christiani D.C. The G to C polymorphism at - 174 of the interleukin-6 gene is rare in a Southern Chinese population. Pharmacogenetics 11 (2001) 699-701
27. Tanner J., and Tosato G. Impairment of natural killer functions by interleukin 6 increases lymphoblastoid cell tumorigenicity in athymic mice. J. Clin. Invest. 88 (1991) 239-247
28. Monteiro E., Varzim G., Pires A.M., Teixeira M., and Lopes C. Cyclin D1 A870G polymorphism and amplification in laryngeal squamous cell carcinoma: implications of tumor localization and tobacco exposure. Cancer Detect Prev. 28 (2004) 237-243
29. Zhou J., Zhao L.Q., Xiong M.M., Wang X.Q., Yang G.R., Qiu Z.L., Wu M., and Liu Z.H. Gene expression profiles at different stages of human esophageal squamous cell carcinoma. World J. Gastroenterol. 9 (2003) 9-15
30. van Leeuwen D.M., van Agen E., Gottschalk R.W., Vlietinck R., Gielen M., van Herwijnen M.H., Maas L.M., Kleinjans J.C., and van Delft J.H. Cigarette smoke-induced differential gene expression in blood cells from monozygotic twin pairs. Carcinogenesis 28 (2007) 691-697