B56β, a regulatory subunit of protein phosphatase 2A, interacts with CALEB/NGC and inhibits CALEB/NGC-mediated dendritic branching

FASEB Journal

Volumn 22, Issue 7, 2008, Pages 2521-2533

  Brandt, Nicola ^a   Franke, Kristin ^a   Johannes, Sascha ^a   Buck, Friedrich ^b   Harder, Sönke ^b   Hasse, Burkhard ^b   Nitsch, Robert ^a   Schumacher, Stefan ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Akt signaling; Dendritic tree elaboration; Mass spectrometry; Neuronal differentiation; Spine morphogenesis

Indexed keywords

EPIDERMAL GROWTH FACTOR; NEUROGLYCAN C; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN B56BETA; PROTEIN CALEB; PROTEIN KINASE B; PROTEIN SUBUNIT; REGULATOR PROTEIN; GLUTATHIONE TRANSFERASE; MEMBRANE PROTEIN; PEPTIDE FRAGMENT; PHOSPHOPROTEIN PHOSPHATASE 2; PPP2R5B PROTEIN, HUMAN;

AFFINITY CHROMATOGRAPHY; ARTICLE; CATALYSIS; CELL DIFFERENTIATION; CONTROLLED STUDY; DENDRITE; HIPPOCAMPUS; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MASS SPECTROMETRY; MORPHOGENESIS; NERVE CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; TWO HYBRID SYSTEM; AMINO ACID SEQUENCE; ANIMAL; BRAIN; CHEMISTRY; ENZYMOLOGY; GENE LIBRARY; GENETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; MOUSE; PHYSIOLOGY; POLYMERASE CHAIN REACTION; ULTRASTRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; BRAIN; CLONING, MOLECULAR; DENDRITES; GENE LIBRARY; GLUTATHIONE TRANSFERASE; HUMANS; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; POLYMERASE CHAIN REACTION; PROTEIN PHOSPHATASE 2; PROTEIN SUBUNITS;

EID: 46749152149     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.07-096115     Document Type: Article

References (32)

1. Jan, Y. N., and Jan, L. Y. (2003) The control of dendrite development. Neuron 40, 229-242
2. Yuste, R., and Bonhoeffer, T. (2004) Genesis of dendritic spines: insights from ultrastructural and imaging studies. Nat. Rev. Neurosci. 5, 24-34
3. Halpain, S., Spencer, K., and Graber, S. (2005) Dynamics and pathology of dendritic spines. Prog. Brain. Res. 147, 29-37
4. Newey, S. E., Velamoor, V., Govek, E. E., and Van Aelst, L. (2005) Rho GTPases, dendritic structure, and mental retardation. J. Neurobiol. 64, 58-74
5. Whitford, K. L., Dijkhuizen, P., Polleux, F., and Ghosh, A. (2002) Molecular control of cortical dendrite development. Annu. Rev. Neurosci. 25, 127-149
6. Hering, H., and Sheng, M. (2001) Dendritic spines: structure, dynamics and regulation. Nat. Rev. Neurosci. 2, 880-888
7. Ethell, I. M., and Pasquale, E. B. (2005) Molecular mechanisms of dendritic spine development and remodeling. Prog. Neurobiol. 75, 161-205
8. Brandt, N., Franke, K., Rasin, M. R., Baumgart, J., Vogt, J., Khrulev, S., Hassel, B., Pohl, E. E., Sestan, N., Nitsch, R., and Schumacher, S. (2007) The neural EGF family member CALEB/NGC mediates dendritic tree and spine complexity. EMBO J. 26, 2371-2386
9. Schumacher, S., Jung, M., Norenberg, U., Dorner, A., Chiquet-Ehrismann, R., Stuermer, C. A., and Rathjen, F. G. (2001) CALEB binds via its acidic stretch to the fibrinogen-like domain of tenascin-C or tenascin-R and its expression is dynamically regulated after optic nerve lesion. J. Biol. Chem. 276, 7337-7345
10. Schumacher, S., and Stube, E. M. (2003) Regulated binding of the fibrinogen-like domains of tenascin-R and tenascin-C to the neural EGF family member CALEB. J. Neurochem. 87, 1213-1223
11. Hassel, B., Schreff, M., Stube, E. M., Blaich, U., and Schumacher, S. (2003) CALEB/NGC interacts with the Golgi-associated protein PIST. J. Biol. Chem. 278, 40136-40143
12. Janssens, V., and Goris, J. (2001) Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem. J. 353, 417-439
13. McCright, B., and Virshup, D. M. (1995) Identification of a new family of protein phosphatase 2A regulatory subunits. J. Biol. Chem. 270, 26123-26128
14. McCright, B., Rivers, A. M., Audlin, S., and Virshup, D. M. (1996) The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. J. Biol. Chem. 271, 22081-22089
15. Zolnierowicz, S., Van Hoof, C., Andjelkovic, N., Cron, P., Stevens, I., Merlevede, W., Goris, J., and Hemmings, B. A. (1996) The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits. Biochem. J. 317, 187-194
16. Seeling, J. M., Miller, J. R., Gil, R., Moon, R. T., White, R., and Virshup, D. M. (1999) Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. Science 283, 2089-2091
17. Li, X., Yost, H. J., Virshup, D. M., and Seeling, J. M. (2001) Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus. EMBO J. 20, 4122-4131
18. Yamamoto, H., Hinoi, T., Michiue, T., Fukui, A., Usui, H., Janssens, V., Van Hoof, C., Goris, J., Asashima, M., and Kikuchi, A. (2001) Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A. J. Biol. Chem. 276, 26875-26882
19. Li, X., Scuderi, A., Letsou, A., and Virshup, D. M. (2002) B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster. Mol. Cell. Biol. 22, 3674-3684
20. Ruvolo, P. P., Clark, W., Mumby, M., Gao, F., and May, W. S. (2002) A functional role for the B56 alpha-subunit of protein phosphatase 2A in ceramide-mediated regulation of Bcl2 phosphorylation status and function. J. Biol. Chem. 277, 22847-22852
21. Letourneux, C., Rocher, G., and Porteu, F. (2006) B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK. EMBO J. 25, 727-738
22. Rocher, G., Letourneux, C., Lenormand, P., and Porteu, F. (2007) Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity. J. Biol. Chem. 282, 5468-5477
23. Schumacher, S., Volkmer, H., Buck, F., Otto, A., Tarnok, A., Roth, S., and Rathjen, F. G. (1997) Chicken acidic leucine-rich EGF-like domain containing brain protein (CALEB), a neural member of the EGF family of differentiation factors, is implicated in neurite formation. J. Cell Biol. 136, 895-906
24. Nakanishi, K., Aono, S., Hirano, K., Kuroda, Y., Ida, M., Tokita, Y., Matsui, F., and Oohira, A. (2006) Identification of neurite outgrowth-promoting domains of neuroglycan C, a brain-specific chondroitin sulfate proteoglycan, and involvement of phosphatidylinositol 3-kinase and protein kinase C signaling pathways in neuritogenesis. J. Biol. Chem. 281, 24970-24978
25. Juttner, R., More, M. I., Das, D., Babich, A., Meier, J., Henning, M., Erdmann, B., Mu ller, E. C., Otto, A., Grantyn, R., and Rathjen, F. G. (2005) Impaired synapse function during postnatal development in the absence of CALEB, an EGF-like protein processed by neuronal activity. Neuron 46, 233-245
26. Jaworski, J., Spangler, S., Seeburg, D. P., Hoogenraad, C. C., and Sheng, M. (2005) Control of dendritic arborization by the phosphoinositide-3′- kinase-Akt-mammalian target of rapamycin pathway. J. Neurosci. 25, 11300-11312
27. Kumar, V., Zhang, M. X., Swank, M. W., Kunz, J., and Wu, G. Y. (2005) Regulation of dendritic morphogenesis by Ras-PI3K-Akt-mTOR and Ras-MAPK signaling pathways. J. Neurosci. 25, 11288-11299
28. Leemhuis, J., Boutillier, S., Scale barth, H., Feuerstein, T. J., Brock, C., Nurnberg, B., Aktories, K., and Meyer, D. K. (2004) Rho GTPases and phosphoinositide 3-kinase organize formation of branched dendrites. J. Biol. Chem. 279, 585-596
29. Yu, X., and Malenka, R. C. (2003) Beta-catenin is critical for dendritic morphogenesis. Nat. Neurosci. 6, 1169-1177
30. Young, D., O'Neill, K., Jessell, T., and Wigler, M. (1988) Characterization of the rat mas oncogene and its high-level expression in the hippocampus and cerebral cortex of rat brain. Proc. Natl. Acad. Sci. U. S. A. 85, 5339-5342
31. Banker, G., and Goslin, K. (eds) (1998) Culturing Nerve Cells, MIT Press, Cambridge, MA, USA
32. Brewer, G. J., Torricelli, J. R., Evege, E. K., and Price, P. J. (1993) Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination. J. Neurosci. Res. 35, 567-576