The role of antioxidant vitamins in hypertensive disorders of pregnancy

Journal of Perinatal Medicine

Volumn 36, Issue 4, 2008, Pages 282-290

  Kontic Vucinic, Olivera ^a   Terzic, Milan ^a   Radunovic, Nebojsa ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Antioxidative vitamins; Hypertensive disorders; Preeclampsia; Pregnancy

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CALCIUM; COPPER; CYANOCOBALAMIN; FOLIC ACID; IRON; MANGANESE; MULTIVITAMIN; PLACEBO; PYRIDOXINE; REACTIVE OXYGEN METABOLITE; RETINOL; SELENIUM; VITAMIN; ZINC;

CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; ENDOTHELIAL DYSFUNCTION; HUMAN; IMMUNOPATHOLOGY; INFLAMMATION; MATERNAL HYPERTENSION; MATERNAL MORBIDITY; OXIDATIVE STRESS; PERINATAL CARE; PLACENTA PERFUSION; PREECLAMPSIA; PREGNANCY DISORDER; PREGNANCY TERMINATION; PRIORITY JOURNAL; REVIEW; TROPHOBLAST; VITAMIN SUPPLEMENTATION;

ANTIOXIDANTS; ASCORBIC ACID; DIETARY SUPPLEMENTS; FEMALE; HUMANS; INFANT, NEWBORN; OXIDATIVE STRESS; PRE-ECLAMPSIA; PREGNANCY; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REACTIVE OXYGEN SPECIES; VITAMIN E;

EID: 46749149189     PISSN: 03005577     EISSN: 16193997     Source Type: Journal    
DOI: 10.1515/JPM.2008.063     Document Type: Review

References (49)

1. ACOG Committee on Practice Bulletins-Obstetrics. ACOG practice bulletin: Diagnosis and management of preeclampsia and eclampsia. Int J Gynaecol Obstet. 2002;77:67-75.
2. ACOG Committee on Practice Bulletins-Obstetrics. ACOG practice bulletin: diagnosis and management of preeclampsia and eclampsia. Obstet Gynecol. 2002;99:159-67.
3. Akyol D, Mungan T, Gorkemli H, Nuhoglu G. Maternal levels of vitamin E in normal and preeclamptic pregnancy. Arch Gynecol Obstet. 2000;263:151-5.
4. Beazley D, Ahokas R, Livingston J, Griggs M, Sibai BM. Vitamin C and E supplementation in women at high risk for preeclampsia: a double-blind, placebo-controlled trial. Am J Obstet Gynecol. 2005;192:520-1.
5. Bodnar LM, Tang G, Ness RB, Harger G, Roberts JM. Periconceptional multivitamine use reduces the risk of preeclampsia. Am J Epidemiol. 2006;164:470-7.
6. Carr A, Frei B. Does vitamin C act as a pro-oxidant under physiological conditions? FASEB J. 1999;13:1007-24.
7. Chappell LC, Seed PT, Briley AL, Kelly FJ, Lee R, Hunt BJ, et al. Effect of antioxidants on occurrence of preeclampsia in women at increased risk: a randomised trial. Lancet. 1999;354:810-6.
8. Chappell LC, Seed PT, Briley AL, Kelly FJ, Hunt BJ, Charnock-Jones DS, et al. A longitudinal study of biochemical variables in women at risk of preeclampsia. Am J Obstet Gynecol. 2002;187:127-36.
9. El-Salahy EM, Ahmed MI, El-Gharieb A, Tawfik H. New scope in angiogenesis: role of vascular endothelial growth factor (VEGF), NO, lipid peroxidation, and vitamin E in the pathophysiology of preeclampsia among Egyptian females. Clin Biochem. 2001;34:323-9.
10. Evans P, Halliwell B. Micronutrients: oxidant/antioxidant status. Br J Nutr. 2001;85:S67-74.
11. Fraser WD, Audibert F, Bujold E, Leduc L, Xu H, Boulvain M, et al. The vitamin E debate: implications for ongoing trials of pre-eclampsia prevention. Br J Obstet Gynecol. 2005;112:684-8.
12. Hamilton IMJ, Gilmore WS, Benzie IFF, Mulholland CW. Interactions between vitamin C and E in human subjects. Br J Nutr. 2000;84:261-7.
13. Hernandez-Diaz S, Werler MM, Mitchell AA. Gestational hypertension in pregnancies supported by infertility treatments: role of infertility, treatments, and multiple gestations. Fertil Steril. 2007;88:438-45.
14. Holmes VA, Young IS, Maresh MJ, Pearson DW, Walker JD, McCance DR, DAPIT Study Group. The Diabetes and Pre-eclampsia Intervention Trial. Int J Gynaecol Obstet. 2004;87:66-71.
15. Hubel CA, McLaughlin MK, Evans RW, Hauth BA, Sims CJ, Roberts JM. Fasting serum triglycerides, free fatty acids, and malondiadehyde are increased in pre-eclampsia, are positively correlated, and decrease within 48 h post partum. Am J Obstet Gynecol. 1996;174:975-82.
16. Karowicz-Bilinska A, Suzin J, Sieroszewski P. Evaluation of oxidative stress indices during treatment in pregnant women with intrauterine growth retardation. Med Sci Monit. 2002;8:211-6.
17. Kharb S. Vitamin E and C in preeclampsia. Eur J Obstet Gynecol Reprod Biol. 2000;93:37-9.
18. May JM, Qu Z, Mendiratta S. Protection and recycling of α-tocopherol in human erythrocytes by intracellular ascorbic acid. Arch Biochem Biophys. 1998;349:281-9.
19. Mignini LE, Latthe PM, Villar J, Kilby MD, Carroli MD, Khan KS. Mapping the theories of preeclampsia: the role of homocysteine. Obstet Gynecol. 2005;105:411-25.
20. Muller-Schmehl K, Beninde J, Finckh B, Florian S, Dudenhausen JW, Brigelius-Flohe R, et al. Localization of alphatocopherol transfer protein in trophoblast, fetal capillaries' endothelium and amnion epithelium of human term placenta. Free Radic Res. 2004;38:413-20.
21. Ness RB, Sibai BM. Shared and disparate components of the pathophysiologies of fetal growth restriction and preeclampsia. Am J Obstet Gynecol. 2006;195:40-9.
22. Osrin D, Vaidya A, Shrestha Y, Baniya RB, Manandhar M, Manandhar D, et al. Effects of antenatal multiple micronutrient supplementation on birthweight and gestational duration in Nepal: double-blind, randomised controlled trial. Lancet. 2005;365:955-62.
23. Poston L, Raijmakers M, Kelly F. Vitamin E in preeclampsia. Ann N Y Acad Sci. 2004;1031:242-8.
24. Poston L, Briley AL, Seed PT, Kelly FJ, Shennan AH. Vitamins in Pre-eclampsia (VIP) Trial Consortium. Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial. Lancet. 2006;367:1145-54.
25. Pressman EK, Cavanaugh JI, Mingione M, Norkus EP, Woods JR. Effects of maternal antioxidant supplementation on maternal and fetal antioxidant levels: a randomized, double-blind study. Am J Obstet Gynecol. 2003;189:1720-5.
26. Raijmakers MT, Dechend R, Poston L. Oxidative stress and pre-eclampsia: rationale for antioxidant clinical trials. Hypertension. 2004;44:374-80.
27. Ramsay JE, Ferrell WR, Crawford L, Wallace AM, Greer IA, Sattar N. Maternal obesity is associated with dysregulation of metabolic, vascular, and inflammatory pathways. J Clin Endocrinol Metab. 2002;87:4231-7.
28. Roberts JM. National Institute of Child Health and Human Development, Maternal Fetal Medicine Units Network. Combined Antioxidant and Preeclampsia Prediction Studies (CAPPS). (Accessed March 31, 2006, at http:// www.clinicaltrials.gov/ct/show/NCT00135707?order=7.).
29. Roberts JM, Redman CWG. Pre-eclampsia: more than pregnancy-induced hypertension. Lancet. 1993;341:1447-51.
30. Roberts JM, Balk JL, Bodnar LM, Belizan JM, Bergel E, Martinez A. Nutrient involvement in preeclampsia. J Nutr. 2003;133:1684S-92S.
31. Rodrigo R, Parra M, Bosco C, Fernandez V, Barja P, Guajardo J, et al. Pathophysiological basis for the prophylaxis of preeclampsia through early supplementation with antioxidant vitamins. Pharmacol Ther. 2005;107:177-97.
32. Rumbold A, Crowther CA. Vitamin C supplementation during pregnancy. Cochrane Database Syst Rev. 2005;2:CD004072.
33. Rumbold A, Crowther CA. Vitamin E supplementation in pregnancy. Cochrane Database Syst Rev. 2005;2:CD004069.
34. Rumbold AR, Crowther CA, Haslam RR, Dekker GA, Robinson JS. Vitamins C and E and the risks of preeclampsia and perinatal complications. N Engl J Med. 2006;354:1796-806.
35. Rumbold A, Duley L, Crowther C, Haslam R. Antioxidants for preventing pre-eclampsia. Cochrane Database Syst Rev. 2008;(1):CD004227.
36. Rumiris D, Purwosunu Y, Wibowo N, Farina A, Sekizawa A. Lower rate of preeclampsia after antioxidant supplementation in pregnant women with low antioxidant status. Hypertens Pregnancy. 2006;25:241-53.
37. Sanchez-Vera I, Bonet B, Viana M, Sanz C. Relationship between alpha-tocopherol content in the different lipoprotein fractions in term pregnant women and in umbilical cord blood. Ann Nutr Metab. 2004;48:146-50.
38. Saugstad OD. Update on oxygen radical disease in neonatology. Curr Opin Obstet Gynecol. 2001;13:147-53.
39. Shenkin A. Micronutrients in health and disease. Postgrad Med J. 2006;82:559-67.
40. Spinnato JA 2nd, Freire S, Pinto E, Silva JL, Cunha Rudge MV, Martins-Costa S, et al. Antioxidant therapy to prevent preeclampsia: a randomized controlled trial. Obstet Gynecol. 2007;110:1311-8.
41. Staff AC, Halvorsen B, Ranheim T, Henriksen T. Elevated level of free 8-iso-prostaglandin F2alpha in the decidua basalis of women with preeclampsia. Am J Obstet Gynecol. 1999;181:1211-5.
42. Stark JM. Preeclampsia and cytokine induced oxidative stress. Br J Obstet Gynaecol. 1993;100:105-9.
43. Villar J, Say L, Shennan A, Lindheimer M, Duley L, Conde-Agudelo A, Merialdi M. Methodological and technical issues related to the diagnosis, screening, prevention, and treatment of pre-eclampsia and eclampsia. Int J Gynaecol Obstet. 2004;85:S28-41.
44. von Mandach U, Huch R, Huch A. Maternal and cord serum vitamin E levels in normal and abnormal pregnancy. Int J Vit Nutr Res. 1994;64:26-32.
45. Wang Y, Walsh SW. Antioxidant activities and mRNA expression of superoxide dismutase, catalase, and glutathione peroxidase in normal and preeclamptic placentas. J Soc Gynecol Investig. 1996;3:179-84.
46. Werler MM, Louik C, Shapiro S, Metchell AA. Prepregnant weight in relation to risk of neural tube defects. J Am Med Assoc. 1996;275:1089-92.
47. WHO. Make every mother and child count. World Health Report, 2005. Geneva: World Health Organization, 2005.
48. Woods JR, Plessinger MA, Miller RK. Vitamin C and E: missing links in preventing preterm premature rupture of membranes? Am J Obstet Gynecol. 2001;185:5-10.
49. Zhang C, Williams MA, King IB, Dashow EE, Sorensen TK, Frederick IO. Vitamin C and the risk of preeclampsia - results from dietary questionnaire and plasma assay. Epidemiology. 2002;13:409-16.