Insulin resistance in chronic hepatitis C, genotypes 1 and 4: The unfortunate reality

Hepatology

Volumn 47, Issue 6, 2008, Pages 2137-2139

  Torres, Dawn M ^a   Harrison, Stephen A ^a  

^a BROOKE ARMY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RNA;

ADULT; AGED; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; INSULIN RESISTANCE; LIVER BIOPSY; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; NOTE; PRIORITY JOURNAL; STEATOSIS;

EID: 46749117217     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.22353     Document Type: Note

References (18)

1. Hickman IJ, Powell EE, Prins JB, Clouston AD, Ash S, Purdie DM, et al. In overweight patients with chronic hepatitis C, circulating insulin is associated with hepatic fibrosis: implications for therapy. J Hepatol 2003;39: 1042-1048.
2. Taura N, Ichikawa T, Hamasaki K, Nakao K, Nishimura D, Goto T, et al. Association between liver fibrosis and insulin sensitivity in chronic hepatitis C patients. Am J Gastroenterol 2006;101:2752-2759.
3. Mehta SH, Brancati FL, Sulkowski SM, Strathdee SA, Szklo M, Thomas DL, et al. Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus infection in the United States. Ann Intern Med 2000; 133:593-599.
4. Zein CO, Levy C, Basu A, Zein NN. Chronic hepatitis C and type II diabetes mellitus: a prospective cross-sectional study. Am J Gastroenterol 2005;100:48-55.
5. Mehta SH, Brancati FL, Strathdee SA, Pankow JS, Netski D, Coresh J, et al. Hepatitis C virus infection and incident type 2 diabetes. HEPATOLOGY 2003;38:50-56.
6. Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Tsukamoto K, Kimura S, et al. Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance. Gastroenterology 2004;126;840-848.
7. Moucari R, Asselah T, Cazals-Hatem D, Voitot H, Boyer N, Ripault M-P, et al. Insulin resistance in chronic hepatitis C: association with genotypes 1 and 4, serum HCV RNA level, and liver fibrosis. Gastroenterology 2008; 134:416-423.
8. Harrison SA. Correlation between insulin resistance and hepatitis C viral load. HEPATOLOGY 2006;43:1168.
9. Hsu CS, Liu CJ, Liu CH, Wang CC, Chen CL, Lai MY, et al. High hepatitis C viral load is associated with insulin resistance in patients with chronic hepatitis C. Liver Int 2008;28:271-277.
10. Leandro G, Mangia A, Hui J, Fabris P, Rubbia-Brandt L, Colloredo G, et al. Relationship between steatosis, inflammation, and fibrosis in chronic hepatitis C: a meta-analysis of individual patient data. Gastroenterology 2006;130:1636-1642.
11. Castéra L, Hézode C, Roudot-Thoraval F, Bastie A, Zafrani ES, Pawlotsky JM, et al. Worsening of steatosis is an independent factor of fibrosis progression in untreated patients with chronic hepatitis C and paired liver biopsies. Gut 2003;52:288-292.
12. Hui JM, Sud A, Farrell GC, Bandara P, Byth K, Kench JG, et al. Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression. Gastroenterology 2003;125:1695-1704.
13. Adinolfi L, Gambardella M, Andreana A, Tripodi MF, Utili R, Ruggiero G. Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity. HEPATOLOGY 2001;33:1358-1364.
14. Matos C, Perez R, Pacheco M, Figueiredo-Mendes CG, Lopes-Neto E, Oliveira EB Jr, et al. Steatosis in chronic hepatitis C: relationship of the virus and host risk factors. J Gastroenterol Hepatol 2006;21:1236-1239.
15. Hourioux C, Patient R, Morin A, Blanchard E, Moreau A, Trassard S, et al. The genotype 3-specific hepatitis C virus core protein residue phenylalanine 164 increases steatosis in an in vitro cellular model. Gut 2007;56: 1302-1308.
16. Jackel-Cram C, Babiuk L, Liu Q. Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: genotype-3a core has a stronger effect than genotype 1-b core. J Hepatol 2006;45:999-1008.
17. Poustchi H, Negro F, Hui J, Cua IH, Brandt LR, Kench JG, et al. Insulin resistance and response to therapy in patients infected with chronic hepatitis C virus genotypes 2 and 3. J Hepatol 2008;48:28-34.
18. Romero-Goméz M, Del Mar Viloria M, Andrade RJ, Salmerón J, Diago M, Fernández-Rodríguez CM, et al. Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis patients. Gastroenterology 2005;128:636-641.