Hyaluronan fragments generated by sperm-secreted hyaluronidase stimulate cytokine/chemokine production via the TLR 2 and TLR4 pathway in cumulus cells of ovulated COCs, which may enhance fertilization

Development

Volumn 135, Issue 11, 2008, Pages 2001-2011

  Shimada, Masayuki ^a   Yanai, Yoshiari ^a   Okazaki, Tetsuji ^a   Noma, Noritaka ^a   Kawashima, Ikkou ^a   Mori, Takahide ^b   Richards, JoAnne S ^c  

^a HIROSHIMA UNIVERSITY   (Japan)

^b Infertility Center   (Japan)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Cumulus cell; Cytokine chemokine; Fertilization; Sperm; Toll like receptor

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; BETA ACTIN; CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR5; CYTOKINE; HYALURONIC ACID; HYALURONIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 9; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUTRALIZING ANTIBODY; RANTES; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TYROSINE;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL CULTURE; COCULTURE; CONTROLLED STUDY; CUMULUS OOPHORUS; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME RELEASE; FEMALE; FERTILIZATION; FERTILIZATION IN VITRO; GENE ACTIVATION; HUMAN; HUMAN CELL; MACROPHAGE; MALE; MOUSE; NONHUMAN; OVULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; SPERMATOCYTE; SPERMATOZOON CAPACITATION;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CHEMOKINES; CUMULUS CELLS; CYTOKINES; FEMALE; FERTILIZATION; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; HYALURONIC ACID; HYALURONOGLUCOSAMINIDASE; MALE; MICE; MICE, INBRED C57BL; OVARIAN FOLLICLE; OVULATION; PEPTIDE FRAGMENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPERMATOZOA; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

BACTERIA (MICROORGANISMS);

EID: 46749110462     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.020461     Document Type: Article

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