Solid-phase synthesis of 4,8-disubstituted-8,9-dihydropyrazino[2,3-g]quinazolin-7(6H)-ones

Biopolymers - Peptide Science Section

Volumn 90, Issue 3, 2008, Pages 439-443

  Zhang, Yandong ^a   Yao, Chao ^a   Houghten, Richard A ^a,b   Yu, Yongping ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

Combinatorial chemistry; Quinazolines; Solid phase

Indexed keywords

AMINES; AMINO ACIDS; ARSENIC COMPOUNDS; CHLORINE COMPOUNDS; COMPLEXATION; ESTERS; KETONES; ORGANIC ACIDS; ORGANIC COMPOUNDS;

AMINO ACID METHYL ESTERS; ARYL-AMINES; CHEMO-SELECTIVE; COMBINATORIAL CHEMISTRY; GOOD YIELDS; INTRAMOLECULAR CYCLIZATION; NITRO GROUPS; QUINAZOLINES; SOLID PHASE; SOLID-PHASE SYNTHESIS;

RESINS;

4 (3,4 DIMETHOXYPHENYLAMINO) 8 ISOBUTYL 8,9 DIHYDROPYRAZINO[2,3 G]QUINAZOLIN 7(6H) ONE; 4 (3,4 DIMETHOXYPHENYLAMINO) 8 METHYL 8,9 DIHYDROPYRAZINO[2,3 G]QUINAZOLIN 7(6H) ONE; 4 (3,4 DIMETHOXYPHENYLAMINO) 8 SEC BUTYL 8,9 DIHYDROPYRAZINO[2,3 G]QUINAZOLIN 7(6H) ONE; 4 (4 FLUOROPHENYLAMINO) 8 SEC BUTYL 8,9 DIHYDROPYRAZINO[2,3 G]QUINAZOLIN 7(6H) ONE; 4 (4 METHOXYPHENYLAMINO) 8 (4 HYDROXYBENZYL) 8,9 DIHYDROPYRAZINO[2,3 G]QUINAZOLIN 7(6H) ONE; 4 (4 METHOXYPHENYLAMINO) 8 ISOBUTYL 8,9 DIHYDROPYRAZINO[2,3 G]QUINAZOLIN 7(6H) ONE; 4 (4 METHOXYPHENYLAMINO) 8 ISOPROPYL 8,9 DIHYDROPYRAZINO[2,3 G]QUINAZOLIN 7(6H) ONE; 4 (4 METHOXYPHENYLAMINO) 8 METHYL 8,9 DIHYDROPYRAZINO[2,3 G]QUINAZOLIN 7(6H) ONE; 4 (4 METHOXYPHENYLAMINO) 8 SEC BUTYL 8,9 DIHYDROPYRAZINO[2,3 G]QUINAZOLIN 7(6H) ONE; 4 (4 METHOXYPHENYLAMINO) 8,9 DIHYDROPYRAZINO[2,3 G]QUINAZOLIN 7(6H) ONE; 4 (4 TERT BUTYLPHENYLAMINO) 8 SEC BUTYL 8,9 DIHYDROPYRAZINO[2,3 G]QUINAZOLIN 7(6H) ONE; 4 (4 TERT BUTYLPHENYLAMINO) 8,9 DIHYDROPYRAZINO[2,3 G]QUINAZOLIN 7(6H) ONE; 4 (4 TOLUIDINO) 8 METHYL 8,9 DIHYDROPYRAZINO[2,3 G]QUINAZOLIN 7(6H) ONE; 4 (4 TOLUIDINO) 8,9 DIHYDROPYRAZINO[2,3 G]QUINAZOLIN 7(6H) ONE; 4 (PHENYLAMINO) 8 ISOPROPYL 8,9 DIHYDROPYRAZINO[2,3 G]QUINAZOLIN 7(6H) ONE; 4 (PHENYLAMINO) 8 SEC BUTYL 8,9 DIHYDROPYRAZINO[2,3 G]QUINAZOLIN 7(6H) ONE; AROMATIC AMINE; QUINAZOLINE; QUINAZOLINE DERIVATIVE; RESIN; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION KINETICS; COMBINATORIAL CHEMISTRY; CYCLIZATION; DRUG PURITY; DRUG STRUCTURE; SOLID PHASE SYNTHESIS; STRUCTURE ANALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STANDARD; SYNTHESIS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMBINATORIAL CHEMISTRY TECHNIQUES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; QUINAZOLINES; REFERENCE STANDARDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 46749096038     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.20842     Document Type: Article

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