Ecto-5′-nucleotidase (CD73)-mediated extracellular adenosine production plays a critical role in hepatic fibrosis

Nucleosides, Nucleotides and Nucleic Acids

Volumn 27, Issue 6-7, 2008, Pages 821-824

  Peng, Zhongsheng ^a   Fernandez, Patricia ^a   Wilder, Tuere ^a   Yee, Herman ^a   Chiriboga, Luis ^a   Chan, Edwin S L ^a   Cronstein, Bruce N ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adenosine; Carbon tetrachloride; Ecto 5 nucleotidase; Hepatic fibrosis; Thioacetamide

Indexed keywords

ADENINE NUCLEOTIDE; ADENOSINE; ADENOSINE RECEPTOR; CARBON TETRACHLORIDE; COLLAGEN; COLLAGEN 1ALPHA1; COLLAGEN 3ALPHA1; ECTO 5' NUCLEOTIDASE; MATRIX METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE; 5' NUCLEOTIDASE;

CONFERENCE PAPER; CONTROLLED STUDY; KNOCKOUT MOUSE; LIVER FIBROSIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; WILD TYPE; ANIMAL; BIOSYNTHESIS; ENZYMOLOGY; EXTRACELLULAR SPACE; FIBROSIS; GENETICS; HUMAN; LIVER; METABOLISM; PATHOLOGY; REVIEW;

5'-NUCLEOTIDASE; ADENOSINE; ANIMALS; EXTRACELLULAR SPACE; FIBROSIS; HUMANS; LIVER;

EID: 46749091643     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770802146403     Document Type: Conference Paper

References (7)

1. Picher, M.; Burch, L.H.; Hirsh, A.J.; Spychala, J.; Boucher, R.C. Ecto 5′-nucleotidase and nonspecific alkaline phosphatase. Two AMP-hydrolyzing ectoenzymes with distinct roles in human airways. J. Biol. Chem. 2003, 278, 13468-13479.
2. Fortuna, R.; Anderson, H.C.; Carty, R.P.; Sajdera, S.W. Enzymatic characterization of the matrix vesicle alkaline phosphatase isolated from bovine fetal epiphyseal cartilage. Calcif. Tissue Int. 1980, 30, 217-225.
3. Naito, Y.; Lowenstein, J.M. 5′-Nucleotidase from rat heart. Biochemistry 1981, 20, 5188-5194.
4. Nagy, L.E.; Diamond, I.; Casso, D.J.; Franklin, C.; Gordon, A.S. Ethanol increases extracellular adenosine by inhibiting adenosine uptake via the nucleoside transporter. J. Biol. Chem. 1990, 265, 1946-1951.
5. Puig, J.G.; Fox, I.H. Ethanol-induced activation of adenine nucleotide turnover. Evidence for a role of acetate. J. Clin. Invest. 1984, 74, 936-941.
6. Chan, E.S.; Montesinos, M.C.; Fernandez, P.; Desai, A.; Delano, D.L.; Yee, H.; Reiss, A.B.; Pillinger, M.H., Chen, J.F.; Schwarzchild, M.A.; Friedman, S.L.; Cronstein, B.N. Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis. Br. J. Pharmacol. 2006, 148, 1144-1155.
7. Morabito, L.; Montesinos, M.C.; Schreibman, D.M.; Balter, L.; Thompson, L.F.; Resta, R.; Carlin, G.; Huie, M.A.; Cronstein, B.N. Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5′-nucleotidase-mediated conversion of adenine nucleotides. J. Clin. Invest. 1998, 101, 295-300.