Autograft versus allograft with or without demineralized bone matrix in posterolateral lumbar fusion in rabbits: Laboratory investigation

Journal of Neurosurgery: Spine

Volumn 9, Issue 1, 2008, Pages 84-89

  Urrutia, Julio ^a,b   Thumm, Nicolas ^a   Apablaza, Daniel ^a   Pizarro, Felipe ^a   Zylberberg, Alejandro ^a   Quezada, Felipe ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b NONE   (Chile)

Author keywords

Allograft; Autograft; Bone graft; Demineralized bone matrix; Rabbit model; Spine fusion

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTHRODESIS; ARTICLE; BONE ALLOGRAFT; BONE GRAFT; BONE MATRIX; CONTROLLED STUDY; ILIAC CREST; INTERMETHOD COMPARISON; LUMBAR SPINE; MALE; NONHUMAN; RABBIT;

ANIMALS; BONE MATRIX; BONE TRANSPLANTATION; LUMBAR VERTEBRAE; MALE; RABBITS; SPINAL FUSION; TRANSPLANTATION, AUTOLOGOUS; TRANSPLANTATION, HOMOLOGOUS;

EID: 46749085833     PISSN: 15475654     EISSN: 15475646     Source Type: Journal    
DOI: 10.3171/SPI/2008/9/7/084     Document Type: Article

References (53)

1. An HS, Lynch K, Toth J: Prospective comparison of autograft vs. allograft for adult posterolateral lumbar spine fusion: differences among freeze-dried, frozen, and mixed grafts. J Spinal Disord 8:131-135, 1995
2. An HS, Simpson JM, Glover JM, Stephany J: Comparison between allograft plus demineralized bone matrix versus autograft in anterior cervical fusion. A prospective multicenter study. Spine 20:2211-2216, 1995
3. Arrington ED, Smith WJ, Chambers HG, Bucknell AL, Davino NA: Complications of iliac crest bone graft harvesting. Clin Orthop Relat Res 329:300-309, 1996
4. Aspenberg P, Thorngren KG, Lohmander LS: Rabbit bone matrix induces bone formation in the athymic rat. Acta Orthop Scand 59:276-278, 1988
5. Bae HW, Zhao L, Kanim LE, Wong P, Delamarter RB, Dawson EG: Intervariability and intravariability of bone morphogenetic proteins in commercially available demineralized bone matrix products. Spine 31:1299-1308, 2006
6. Berven S, Tay BK, Kleinstueck FS, Bradford DS: Clinical applications of bone graft substitutes in spine surgery: consideration of mineralized and demineralized preparations and growth factor supplementation. Eur Spine J 10 (2 Suppl):S169-S177, 2001
7. Boden SD, Martin GJ Jr, Horton WC, Truss TL, Sandhu HS: Laparoscopic anterior spinal arthrodesis with rhBMP-2 in a titanium interbody threaded cage. J Spinal Disord 11:95-101, 1998
8. Boden SD, Schimandle JH, Hutton WC: An experimental lumbar intertransverse process spinal fusion model. Radiographic, histologic and biomechanical healing characteristics. Spine 20:412-420, 1995
9. Boden SD, Zdeblick TA, Sandhu HS, Heim SE: The use of rhBMP-2 in interbody fusion cages. Definitive evidence of osteoinduction in humans: a preliminary report. Spine 25:376-381, 2000
10. Bridwell KH, Sedgewick TA, O'Brien MF, Lenke LG, Baldus C: The role of fusion and instrumentation in the treatment of degenerative spondylolisthesis with spinal stenosis. J Spinal Disord 6:461-472, 1993
11. Burkus JK, Dorchak JD, Sanders DL: Radiographic assessment of interbody fusion using recombinant human bone morphogenetic protein type 2. Spine 28:372-377, 2003
12. Burkus JK, Gornet MF, Dickman CA, Zdeblick TA: Anterior lumbar interbody fusion using rhBMP-2 with tapered interbody cages. J Spinal Disord Tech 15:337-349, 2002
13. Burkus JK, Heim SE, Gornet MF, Zdeblick TA: Is INFUSE bone graft superior to autograft bone? An integrated analysis of clinical trials using the LT-CAGE lumbar tapered fusion device. J Spinal Disord Tech 16:113-122, 2003
14. Burkus JK, Transfeldt EE, Kitchel SH, Watkins RG, Balderston RA: Clinical and radiographic outcomes of anterior lumbar interbody fusion using recombinant human bone morphogenetic protein-2. Spine 27:2396-2408, 2002
15. Dahners LE, Jacobs RR: Long bone defects treated with demineralized bone. South Med J 78:933-934, 1985
16. Erulkar JS, Grauer JN, Patel TC, Panjabi MM: Flexibility analysis of posterolateral fusions in a New Zealand white rabbit model. Spine 26:1125-1130, 2001
17. Feiertag M, Boden SD, Schimandle J, Norman J: A rabbit model for nonunion of lumbar intertransverse process spine arthrodesis. Spine 21:27-31, 1996
18. Fernyhough JC, Schimandle JH, Weigel MC, Edwards CC, Levine AM: Chronic donor site pain complicating bone graft harvesting from the posterior iliac crest for spinal fusion. Spine 17:1474-1480, 1992
19. Frenkel SR, Moskovich R, Spivak J, Zhang ZH, Prewett AB: Demineralized bone matrix. Enhancement of spinal fusion. Spine 18:1634-1639, 1993
20. Friedlaender GE: Bone allografts: the biological consequences of immunological events. J Bone Joint Surg Am 73:1119-1122, 1991
21. Gazdag AR, Lane JM, Glaser D, Forster R: Alternatives to autogenous bone graft: efficacy and indications. J Am Acad Orthop Surg 3:1-8, 1995
22. Guizzardi S, Di Silvestre M, Scandroglio R, Ruggeri A, Savini R: Implants of heterologous demineralized bone matrix for induction of posterior spinal fusion in rats. Spine 17:701-707, 1992
23. Karaismailoǧlu TN, Tomak Y, Andaç A, Ergün E: [Comparison of autograft, coralline graft, and xenograft in promoting posterior spinal fusion.] Acta Orthop Traumatol Turc 36:147-154, 2002 (Turkish)
24. Lee Y, Jo M, Luna M, Chien B, Lieberman J, Wang J: The efficacy of different commercially available demineralized bone matrix substances in an athymic rat model. J Spinal Disord Tech 18:439-444, 2005
25. Löfgren H, Johannsson V, Olsson T, Ryd L, Levander B: Rigid fusion after cloward operation for cervical disc disease using autograft, allograft, or xenograft: a randomized study with radiostereometric and clinical follow-up assessment. Spine 25:1908-1916, 2000
26. Louis-Ugbo J, Murakami H, Kim HS, Minamide A, Boden SD: Evidence of osteoinduction by Grafton demineralized bone matrix in nonhuman primate spinal fusion. Spine 29:360-366, 2004
27. Malca SA, Roche PH, Rosset E, Pellet W: Cervical interbody xenograft with plate fixation: evaluation of fusion after 7 years of use in post-traumatic discoligamentous instability. Spine 21:685-690, 1996
28. Martin G, Boden SD, Titus L, Scarborough NL: New formulations of demineralized bone matrix as a more effective graft alternative in experimental posterolateral lumbar spine arthrodesis. Spine 24:637-645, 1999
29. Martin GJ Jr, Boden SD, Titus L: Recombinant human bone morphogenetic protein-2 overcomes the inhibitory effect of ketorolac, a nonsteroidal anti-inflammatory drug (NSAID), on posterolateral lumbar intertransverse process spine fusion. Spine 24:2188-2193, 1999
30. Morone MA, Boden SD: Experimental posterolateral lumbar spinal fusion with a demineralized bone matrix gel. Spine 23:159-167, 1998
31. Nemzek JA, Arnoczky SP, Swenson CL: Retroviral transmission in bone allotransplantation. The effects of tissue processing. Clin Orthop Relat Res 324:275-282, 1996
32. Peterson B, Whang PG, Iglesias R, Wang JC, Lieberman JR: Osteoinductivity of commercially available demineralized bone matrix. Preparations in a spine fusion model. J Bone Joint Surg Am 86:2243-2250, 2004
33. Prolo DJ, Rodrigo JJ: Contemporary bone graft physiology and surgery. Clin Orthop Relat Res 200:322-342, 1985
34. Ragni P, Lindholm TS: Interaction of allogeneic demineralized bone matrix and porous hydroxyapatite bioceramics in lumbar interbody fusion in rabbits. Clin Orthop Relat Res 272:292-299, 1991
35. Reddi AH: Bone morphogenetic proteins, bone marrow stromal cells, and mesenchymal stem cells. Clin Orthop Relat Res 313:115-119, 1995
36. Riley EH, Lane JM, Urist MR, Lyons KM, Lieberman JR: Bone morphogenetic protein-2: biology and application. Clin Orthop Relat Res 324:39-46, 1996
37. Sandhu HS: Bone morphogenetic proteins and spinal surgery. Spine 28 (15 Suppl):S64-S73, 2003
38. Sandhu HS, Boden SD: Biologic enhancement of spinal fusion. Orthop Clin North Am 29:621-631, 1998
39. Schimandle JH, Boden SD: The use of animal models to study spinal fusion. Spine 19:1998-2006, 1999
40. Schimandle JH, Boden SD, Hutton WC: Experimental spinal fusion with recombinant human bone morphogenetic protein-2. Spine 20:1326-1337, 1995
41. Schultheiss M, Sarkar M, Arand M, Kramer M, Wilke HJ, Kinzl L, et al: Solvent-preserved, bovine cancellous bone blocks used for reconstruction of thoracolumbar fractures in minimally invasive spinal surgery-first clinical results. Eur Spine J 14:192-196, 2005
42. Sidhu KS, Herkowitz HN: Spinal instrumentation in the management of degenerative disorders of the lumbar spine. Clin Orthop Relat Res 335:39-53, 1997
43. Silcox DH III, Daftari T, Boden SD, Schimandle JH, Hutton WC, Whitesides TE Jr: The effect of nicotine on spinal fusion. Spine 20:1549-1553, 1995
44. Summers BN, Eisenstein SM: Donor site pain from the ilium. A complication of lumbar spine fusion. J Bone Joint Surg Br 71:677-680, 1989
45. Yoon ST, Boden SD: Osteoinductive molecules in orthopaedics: basic science and preclinical studies. Clin Orthop Relat Res 395:33-43, 2002
46. Urist MR: Bone: formation by autoinduction. Science 150:893-899, 1965
47. Urist MR, Mikulski A, Lietze A: Solubilized and insolubilized bone morphogenetic protein. Proc Natl Acad Sci U S A 76:1828-1832, 1979
48. Vaccaro AR, Chiba K, Heller JG, Patel TC, Thalgott JS, Truumees E, et al: Bone grafting alternatives in spinal surgery. Spine J 2:206-215, 2002
49. Vaccaro AR, Garfin SR: Internal fixation (pedicle screw fixation) for fusions of the lumbar spine. Spine 20 (24 Suppl):157S-165S, 1995
50. Wang JC, Alanay A, Mark D, Kanim LE, Campbell PA, Dawson EG, et al: A comparison of commercially available demineralized bone matrix for spinal fusion. Eur Spine J 16:1233-1240, 2007
51. West JL, Ogilvie JW, Bradford DS: Pedicle screw plate fixation with allograft bone. Orthopaedic Transactions 15:733, 1991
52. Younger EM, Chapman MW Morbidity at bone graft donor sites. J Orthop Trauma 3:192-195, 1989
53. Zdeblick TA: A prospective, randomized study of lumbar fusion. Preliminary results. Spine 18:983-991, 1993