Simvastatin plus nitric oxide synthase inhibition modulates remote organ damage following skeletal muscle ischemia-reperfusion injury

Journal of Investigative Surgery

Volumn 21, Issue 3, 2008, Pages 119-126

  Cowled, P A ^a   Khanna, A ^a,b   Laws, P E ^a,c   Field, J B F ^a   Fitridge, R A ^d  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c WORTHING HOSPITAL   (United Kingdom)

^d UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Ischemia reperfusion injury; Kidney; Lung; Neutrophil; Nitric oxide; Skeletal muscle; Statin

Indexed keywords

COLLAGEN TYPE 4; GELATINASE B; MYELOPEROXIDASE; N5 (1 IMINOETHYL)ORNITHINE; NITRIC OXIDE SYNTHASE; SIMVASTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; COLLAGEN DEGRADATION; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME INHIBITION; IMMUNOHISTOCHEMISTRY; KIDNEY INJURY; KIDNEY PARENCHYMA; LUNG INJURY; LUNG PARENCHYMA; MALE; MONOTHERAPY; MUSCLE ISCHEMIA; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RENAL PROTECTION; REPERFUSION INJURY; SINGLE DRUG DOSE; VASCULAR SURGERY;

ANIMALS; COLLAGEN TYPE IV; ENZYME INHIBITORS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MATRIX METALLOPROTEINASE 9; MUSCLE, SKELETAL; NITRIC OXIDE SYNTHASE; ORNITHINE; PEROXIDASE; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RNA, MESSENGER; SIMVASTATIN;

EID: 46649115559     PISSN: 08941939     EISSN: 15210553     Source Type: Journal    
DOI: 10.1080/08941930802046501     Document Type: Article

References (31)

1. Norwood, M. G., Bown, M. J. and Sayers, R. D. (2004) Ischaemia-reperfusion injury and regional inflammatory responses in abdominal aortic aneurysm repair. Eur J Vasc Endovasc Surg, 28, pp. 234-245.
2. Adembri, C., Kastamoniti, E. Bertolozzi, L. et al. (2004) Pulmonary injury follows systemic inflammatory reaction in infrarenal aortic surgery. Crit Care Med, 32, pp. 1170-1177.
3. Groeneveld, A. B., Raijmakers, P. G. Rauwerda, J. A. et al. (1997) The inflammatory response to vascular surgery-associated ischaemia and reperfusion in man: Effect on postoperative pulmonary function. Eur J Vasc Endovasc Surg, 14, pp. 351-359.
4. Tallgren, M., Niemi, T. Poyhia, R. et al. (2007) Acute renal injury and dysfunction following elective abdominal aortic surgery. Eur J Vasc Endovasc Surg, 33, pp. 550-555.
5. Laws, P. E., Spark, J. I. Cowled, P. A. et al. (2004) The role of statins in vascular disease. Eur J Vasc Endovasc Surg, 27, pp. 6-16.
6. Cowled, P. A., Khanna, A. Laws, P. E. et al. (2007) Statins inhibit neutrophil infiltration in skeletal muscle reperfusion injury. J Surg Res, 141, pp. 267-276.
7. Dillon, J. P., Laing, A. J. Chandler, J. R. et al. (2006) Pravastatin attenuates tourniquet-induced skeletal muscle ischemia reperfusion injury. Acta Orthop, 77, pp. 27-32.
8. Emanueli, C., Monopoli, A. Kraenkel, N. et al. (2007) Nitropravastatin stimulates reparative neovascularisation and improves recovery from limb Ischaemia in type-1 diabetic mice. Br J Pharmacol, 150, pp. 873-882.
9. Cowled, P. A., Leonardos, L. Millard, S. H. et al. (2001) Apoptotic cell death makes a minor contribution to reperfusion injury in skeletal muscle in the rat. Eur J Vasc Endovasc Surg, 21, pp. 28-34.
10. Roach, D. M., Fitridge, R. A. Laws, P. E. et al. (2002) Up-regulation of MMP-2 and MMP-9 leads to degradation of type IV collagen during skeletal muscle reperfusion injury; protection by the MMP inhibitor, doxycycline. Eur J Vasc Endovasc Surg, 23, pp. 260-269.
11. Lindsey, M., Wedin, K., Brown, M. D., Keller, C., Evans, A. J. and Smolen, J. (2001) Matrix-dependent mechanism of neutrophil-mediated release and activation of matrix metalloproteinase 9 in myocardial ischemia/reperfusion. Circulation, 103, pp. 2181-2187.
12. Hernandez-Perera, O., Perez-Sala, D. Navarro-Antolin, J. et al. (1998) Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells. J Clin Invest, 101, pp. 2711-2719.
13. Wagner, A. H., Schwabe, O. and Hecker, M. (2002) Atorvastatin inhibition of cytokine-inducible nitric oxide synthase expression in native endothelial cells in situ. Br J Pharmacol, 136, pp. 143-149.
14. Tanaka, J., Ishida, Y. Ohshima, T. et al. (2003) The gene expression of cytokines and chemokines induced by tourniquet shock in mice. Leg Med (Tokyo), 5, pp. 146-155.
15. Tiefenbacher, C. P., Kapitza, J. Dietz, V. et al. (2003) Reduction of myocardial infarct size by fluvastatin. Am J Physiol Heart Circ Physiol, 285, p. H59.
16. Trinkl, A., Vosko, M. R. Wunderlich, N. et al. (2006) Pravastatin reduces microvascular basal lamina damage following focal cerebral ischemia and reperfusion. Eur J Neurosci, 24, pp. 520-526.
17. Sun, X. F., Wang, L. L. Wang, J. K. et al. (2007) Effects of simvastatin on lung injury induced by ischaemia-reperfusion of the hind limbs in rats. J Int Med Res, 35, pp. 523-533.
18. Joyce, M., Kelly, C. J. Chen, G. et al. (2001) Pravastatin attenuates lower torso ischaemia-reperfusion-induced lung injury by upregulating constitutive endothelial nitric oxide synthase. Eur J Vasc Endovasc Surg, 21, pp. 295-300.
19. Khanna, A., Cowled, P. A. and Fitridge, R. A. (2005) Nitric oxide and skeletal muscle reperfusion injury: Current controversies (research review). J Surg Res, 128, pp. 98-107.
20. Wang, W. Z., Fang, X. H. Stephenson, L. L. et al. (2005) Microcirculatory effects of melatonin in rat skeletal muscle after prolonged ischemia. J Pineal Res, 39, pp. 57-65.
21. Zimiani, K., Guarnier, F. A. Miranda, H. C. et al. (2005) Nitric oxide mediated oxidative stress injury in rat skeletal muscle subjected to ischemia/reperfusion as evaluated by chemiluminescence. Nitric Oxide, 13, pp. 196-203.
22. Di Napoli, P, Taccardi, A. A. Grilli, A. et al. (2005) Chronic treatment with rosuvastatin modulates nitric oxide synthase expression and reduces ischemia-reperfusion injury in rat hearts. Cardiovasc Res, 66, pp. 462-471.
23. Madonna, R., Di Napoli, P Massaro, M. et al. (2005) Simvastatin attenuates expression of cytokine-inducible nitric-oxide synthase in embryonic cardiac myoblasts. J Biol Chem, 280, pp. 13503-13511.
24. McCall, T. B., Feelisch, M. Palmer, R. M. et al. (1991) Identification of N-iminoethyl-L-ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells. Br J Pharmacol, 102, pp. 234-238.
25. Rees, D. D., Palmer, R. M. Schulz, R. et al. (1990) Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol, 101, pp. 746-752.
26. Harkin, D. W., Rubin, B. B. Romaschin, A. et al. (2004) Selective inducible nitric oxide synthase (iNOS) inhibition attenuates remote acute lung injury in a model of ruptured abdominal aortic aneurysm. J Surg Res, 120, pp. 230-241.
27. Qi, W. N., Chen, L. E. Zhang, L. et al. (2004) Reperfusion injury in skeletal muscle is reduced in inducible nitric oxide synthase knockout mice. J Appl Physiol, 97, pp. 1323-1328.
28. Rivera-Chavez, F. A., Toledo-Pereyra, L. H. Dean, R. E. et al. (2001) Exogenous and endogenous nitric oxide but not iNOS inhibition improves function and survival of ischemically injured livers. J Invest Surg, 14, pp. 267-273.
29. Cuzzocrea, S., Misko, T. P. Costantino, G. et al. (2000) Beneficial effects of peroxynitrite decomposition catalyst in a rat model of splanchnic artery occlusion and reperfusion. Faseb J, 14, pp. 1061-1072.
30. Heart Protection Study Collaborative Group (2002) MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: A randomised placebo-controlled trial. Lancet, 360, pp. 7-22.
31. Heart Protection Study Collaborative Group (2007) Randomized trial of the effects of cholesterol-lowering with simvastatin on peripheral vascular and other major vascular outcomes in 20,536 people with peripheral arterial disease and other high-risk conditions. J Vasc Surg, 45, pp. 645-654.