The naturally occurring flavolignan, deoxypodophyllotoxin, inhibits lipopolysaccharide-induced iNOS expression through the NF-κB activation in RAW264.7 macrophage cells

Biological and Pharmaceutical Bulletin

Volumn 31, Issue 7, 2008, Pages 1312-1315

  Jin, Meihua ^a   Moon, Tae Chul ^b   Quan, Zhejiu ^a   Lee, Eunkyung ^c   Kim, Yun Kyung ^a   Yang, Ju Hae ^a   Suh, Seok Jong ^d   Jeong, Tae Cheon ^a   Lee, Seung Ho ^a   Kim, Cheorl Ho ^d   Chang, Hyeun Wook ^a  

^a Yeungnam University   (South Korea)

^b UNIVERSITY OF ALBERTA   (Canada)

^c Daegu Gyeongbuk Institute for Oriental Medicine Industry   (South Korea)

^d Sungkyunkwan University   (South Korea)

Author keywords

Deoxypodophyllotoxin; Electrophoretic mobility shift analysis; Inducible nitric oxide synthase; Nuclear factor B; Pyrrolidinedithiocarbamate; RAW264.7 cell

Indexed keywords

DEOXYPODOPHYLLOTOXIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; SYNAPTOTAGMIN I;

ANIMAL CELL; ANTHRISCUS SYLVESTRIS; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ISOLATION; ENZYME ACTIVITY; GEL MOBILITY SHIFT ASSAY; GENE REPRESSION; MACROPHAGE ACTIVATION; MEDICINAL PLANT; MOUSE; NONHUMAN; PLANT ROOT; PROTEIN DNA BINDING; REPORTER GENE;

ANIMALS; APIACEAE; BLOTTING, WESTERN; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; DNA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; INDICATORS AND REAGENTS; LIPOPOLYSACCHARIDES; LUCIFERASES; MACROPHAGES; MAGNETIC RESONANCE SPECTROSCOPY; MICE; NITRIC OXIDE SYNTHASE TYPE II; PLANT ROOTS; PODOPHYLLOTOXIN; TRANSCRIPTION FACTOR RELA; TRANSFECTION;

EID: 46449100372     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.31.1312     Document Type: Article

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