Measurement of bone blood flow using the hydrogen washout technique - Part I: Quantitative evaluation of tissue perfusion in the laboratory rat

Journal of Orthopaedic Research

Volumn 26, Issue 6, 2008, Pages 741-745

  Pelzer, Michael ^a,b   Larsen, Mikko ^a,c   Friedrich, Patricia F ^a   Bishop, Allen T ^a  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Blood flow; Bone; Hydrogen washout

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BIOSENSOR; BONE BLOOD FLOW; COMPUTER PROGRAM; CONTROLLED STUDY; DIAGNOSTIC TEST; HYDROGEN WASH OUT; MECHANICAL PROBE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; TISSUE PERFUSION; ANIMAL; BIOLOGICAL MODEL; BLOOD FLOW; BONE; ELECTRODE; INSTRUMENTATION; METHODOLOGY; MICROMANIPULATION; PERFUSION; REPRODUCIBILITY; STANDARD; VASCULARIZATION;

DIAGNOSTIC AGENT; HYDROGEN;

ANIMALS; BONE AND BONES; ELECTRODES; HYDROGEN; MICROMANIPULATION; MODELS, CARDIOVASCULAR; PERFUSION; RATS; REGIONAL BLOOD FLOW; REPRODUCIBILITY OF RESULTS;

EID: 46449096451     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1002/jor.20562     Document Type: Article

References (15)

1. Anetzberger H, Thein E, Becker M, et al. 2003. Validity ot fluorescent microspheres method for bone blood flow measurement during intentional arterial hypotension. J Appl Physiol 95:1153-1158.
2. Tu YK, Bishop AT, Kato T, et al. 2000. Experimental carpal reverse-flow pedicle vascularized bone grafts. Part II: bone blood flow measurement by radioactive-labeled microspheres in a canine model. J Hand Surg [Am] 25:46-54.
3. Wongtrakul S, Bishop AT, Friedrich PF. 2002. Vascular endothelial growth factor promotion of neoangiogenesis in conventional nerve grafts. J Hand Surg [Am] 27:277-285.
4. Suzuki O, Bishop AT, Sunagawa T, et al. 2004. VEGF-promoted surgical angiogenesis in necrotic bone. Microsurgery 24:85-91.
5. McGrory BJ, Moran CG, Bronk J, et al. 1994. Canine bone blood flow measurements using serial microsphere injections. Clin Orthop 303:264-279.
6. McCarthy JD. 1998. Blood flow and transport in bone. In: Hughes SM, McCarthy JD, editors. Sciences basic to orthopaedics. London: WB Saunders; p 15-27.
7. Lausten GS, Kiaer T, Dahl B. 1993. Laser Doppler flowmetry for estimation of bone blood flow: studies of reproducibility and correlation with microsphere technique. J Orthop Res 11:573-580.
8. Kety SS, Schmidt CF. 1945. The determination of cerebral blood flow in man by the use of nitrous oxide in low concentrations. Am J Physiol 143:53.
9. Aukland K, Bower BF, Berliner RW. 1964. Measurement of local blood flow with hydrogen gas. Circ Res 14:164-187.
10. Whiteside LA, Lesker PA, Simmons DJ. 1977. Measurement of regional bone and bone marrow blood flow in the rabbit using the hydrogen washout technique. Clin Ortho 122:340-346.
11. Dole WP, Jackson DL, Rosenblatt JI, et al. 1982. Relative error and variability in blood flow measurements with radio-labeled microspheres. Am J Physiol 243:H371-H378.
12. Stanek KA, Smith TL, Murphy WR, et al. 1983. Hemodynamic disturbances in the rat as a function of the number of microspheres injected. Am J Physiol 245:H920-923.
13. Tothill P, MacPherson JM. 1980. Limitations of radioactive microspheres as tracers for bone blood flow and extraction ratio studies. Calcif Tissue Int 31:261-265.
14. Hellem S, Jacobsson LS, Nilsson GE, et al. 1983. Measurement of microvascular blood flow in cancellous bone using laser Doppler flowmetry and 133Xe-clearance. Int J Oral Surg 12:165-177.
15. Jain R, Podworny N, Schemitsch EH. 2000. In vivo assessment of second generation implantable laser Doppler flowmetry fibres for bone blood flow determination. Int J Surg Invest 2:89-98.