Clinical application of cerebrospinal fluid neopterin concentrations in HIV infection

Pteridines

Volumn 15, Issue 3, 2004, Pages 102-106

  Hagberg, Lars ^a   Andersson, Lars Magnus ^a   Abdulle, Sahra ^a   Gisslén, Magnus ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Antiretroviral therapy; Cerebrospinal fluid; HIV; Neopterin

Indexed keywords

ALBUMIN; ANTIRETROVIRUS AGENT; CD4 ANTIGEN; NEOPTERIN; NEUROFILAMENT PROTEIN; VIRUS RNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CEREBROSPINAL FLUID; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; RADIOIMMUNOASSAY; VIRUS LOAD;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 4644371877     PISSN: 09334807     EISSN: 21954720     Source Type: Journal    
DOI: 10.1515/pteridines.2004.15.3.102     Document Type: Article

References (23)

1. Ho DD, Rota TR, Schooley RT, Kaplan JC, Allan JD, Groopman JE et al. Isolation of HTLV-III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome. N Engl J Med 1985; 313:1493-1497
2. Chiodi F, Keys B, Albert J, Hagberg L, Lundeberg J, Uhlén M, Fenyö E-M, Norkrans G: HIV-1 is present in the cerebrospinal fluid of the majority of infected individuals. J Clin Microbiol 1992; 30:1768-1771.
3. Davis LE, Hjelle BL, Miller VE, Palmer DL, Llewellyn AL, Merlin TL et al. Early viral brain invasion in iatrogenic human immunodeficiency virus infection. Neurology 1992; 42:1736-1739
4. Gisslen, M, Chiodi F, Fuchs D, Norkrans G, Svennerholm B, Wachter H, Hagberg L. Markers of immune stimulation in the cerebrospinal fluid during HIV infection: a longitudinal study. Scand J Infect Dis 1994; 26(5):523-533.
5. Portegies P, de Gans J, Lange JM, Derix MM, Speelman H, Bakker M, Danner SA, Goudsmith J. Declining incidence of AIDS dementia after introduction of zidovudine treatment. Br Med J 1989; 299:819-821.
6. Trujillo JR, Garcia-Romeos G, Novak IS, Rivera VM, Huerta E, Essex M. Neurologic manifestations of AIDS: a comparative study of 2 populations from Mexico and the United States. J Acquir Immune Defic Syndr Hum Retrovirol 1995; 8:23-29.
7. Price RW, Brew BJ. The Aids dementia complex. J Infect Dis 1988; 158:1079-1083
8. Brew BJ, Dunbar N, Pemberton L, Kaldor J. Predicitive markers of AIDS dementia complex: CD4 cell count and cerebrospinal fluid concentrations of beta-2microglobulin and neopterin. J Infect Dis 1996; 174:294-298.
9. Hagberg L, Dotevall L, Norkrans G, Larsson M, Wachter H, Fuchs D. Cerebrospinal fluid neopterin concentration in central nervous system infection. J Infect Dis 1993; 168:1285-1288
10. Fuchs D, Chiodi F, Albert J, et al., Neopterin concentrations in cerebrospinal fluid and serum of individuals infected with HIV-1. AIDS 1989; 3(5):285-287.
11. Bogner JR, Junge-Hulsing B, Kronawitter U, Sadri I, Matuschke A, Goebel FD. Expansion of neopterin and course of human immunodeficiency virus infection. Clin. Investig 1992; 70:665-669.
12. Sönnerborg A, von Stedingk LV, Hansson LO, Strannegard Ö. Elevated neopterin and beta 2-microglobulin levels in blood and cerebrospinal fluid occur early in HIV-1 infection. AIDS 1989; 3(5):277-283.
13. Gisslén M, Hagberg L, Fuchs D, Norkrans G, Svennerholm B. Cerebrospinal fluid viral load in HIV-1 infected patients without antiretroviral treatment: a longitudinal study. J Aquir Immune Defic Syndr Hum Retrovirol 1998; 17:291-295.
14. Andersson LM, Hagberg L, Fuchs D, Svennerholm B, Gisslén M. Increased blood-brain barrier permeability in neuro-asymptomatic HIV-1 infected individuals-correlation with cerebrospinal fluid HIV-1 RNA and neopterin levels. J of NeuroVirology 2001; 7:542-547.
15. Hagberg L. The clinical use of cerebrospinal fluid neopterin concentrations in central nervous system infections. Pteridins 1995; 6:147-152.
16. Gisslén M, Fuchs D, Svennerholm B, Hagberg L. Cerebrospinal fluid viral load, intrathecal immunoactivation and cerebrospinal fluid monocytic cell count in HIV-1 infection. JAIDS 1999; 21, 271-276.
17. Bogner JR, Junge-Hulsing B, Kronawitter U, Sadri I, Matuschke A, Goebe FD. Expansion of neopterin and beta2-microglobulin in cerebrospinal fluid reaches maximum levels early and late in the course of human immunodificiency virus infection. Clin Invest 1992; 70:665-669.
18. Gisslen, M., G. Norkrans, B. Svennerholm, Hagberg L. HIV-1 RNA detectable with ultrasensitive quantitative polymerase chain reaction in plasma but not in cerebrospinal fluid during combination treatment with zidovudine, lamivudine and indinavir. AIDS 1998; 12(1):114-116.
19. Gisslen, M., B. Svennerholm, D. Fuchs, Hagberg L., Neurological efficacy of stavudine, zidovudine, and lamivudine. Lancet, 1998. 352(9125): 402-403.
20. Abdulle S, Hagberg L, Svennerholm B, Fuchs D, Gisslén M. Continuing intrathecal immunoactivation despite two years of effective antiretroviral therapy against HIV-1 infection. AIDS 2002; 16:2145-2149.
21. Gisslén M, Svennerholm B, Norkrans G, Franzén C, Säll C, Svensson R, Öberg S, Hagberg L. Cerebrospinal fluid and plasma viral load in HIV-1 infected patients with various antiretroviral treatment regimens. Scand J Infect Dis 2000; 32:365-369
22. Aurelius E, Forsgren M, Sköldenberg B, Strannegard Ö. Persistent intrathecal immune activation in patients with herpes simplex encephalitis. J Infect Dis 1993; 168:1248-1252.
23. Hagberg L, Gisslén M, Rosengren L. Cerebrospinal fluid signs of neuronal destruction in patients with human immunodeficiency virus infection. J Neuroimmunol. 2000; 102:51-55.