Development of a new analgesic based on metabolism of endomorphin, an endogenous opioid peptide

Yakugaku Zasshi

Volumn 124, Issue 8, 2004, Pages 549-554

  Sakurada, Chikai ^a,b  

^a DAIICHI UNIVERSITY OF PHARMACY   (Japan)

^b NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Antinociception; Dipeptidyl peptidase IV; Endomorphin 2; Metabolic pathway; Mouse brain; Synaptic membranes

Indexed keywords

3 (2 INDANYLACETYL) 4 (1 PYRROLIDINYLCARBONYL)THIAZOLIDINE; AMINOPEPTIDASE; ANALGESIC AGENT; BESTATIN; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; DIPROTIN A; DIPROTIN B; ENALAPRIL; ENDOMORPHIN 2; ENDORPHIN; ENDORPHIN DERIVATIVE; ENZYME INHIBITOR; OPIATE PEPTIDE; PHENYLALANINE; PHOSPHORAMIDON; TYROSINE; OLIGOPEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; BRAIN; CONTROLLED STUDY; DEGRADATION; DRUG EFFICACY; MOUSE; NONHUMAN; REVIEW; SYNAPTIC MEMBRANE; ANIMAL; DRUG DESIGN; HUMAN; METABOLISM; PHYSIOLOGY;

ANALGESICS; ANIMALS; ANTIGENS, CD26; BRAIN; DRUG DESIGN; HUMANS; MICE; OLIGOPEPTIDES; SYNAPTIC MEMBRANES;

EID: 4644371616     PISSN: 00316903     EISSN: None     Source Type: Journal    
DOI: 10.1248/yakushi.124.549     Document Type: Review

References (10)

1. Zadina J. E., Hackler L., Ge L. J., Kastin A. J., Nature, 386, 499-502 (1997).
2. Mansour A., Fox C. A., Burke S., Akil H., Watson S. J., J. Chem. Neuroanat., 8, 283-305 (1995).
3. Goldberg I. E., Rossi G. C., Letchworth S. R., Mathis J. P., Ryan-Moro J., Leventhal L., Su W., Emmel D., Bolan E. A., Pasternak G. W., J. Pharmacol. Exp. Ther., 286, 1007-1013 (1998).
4. Sakurada S., Zadina J. E., Kastin A. J., Katsuyama S., Fujimura T., Murayama K., Yuki M., Ueda H., Sakurada T., Eur. J. Pharmacol., 372, 25-30 (1999).
5. Stone L. S., Fairbanks C. A., Laughlin T. M., Nguyen H. O., Bushy T. M., Wessendorf M. W., Wilcox G., NeuroReport, 8, 3131-3135 (1997).
6. Sakurada S., Hayashi T., Yuhki M., Fujimura T., Murayama K., Yonezawa A., Sakurada C., Takeshita M., Sato T., Zadina J. E., Kastin A. J., Sakurada T., Peptides, 23, 895-901 (2002).
7. Mizoguchi H., Narita M., Oji D. E., Suganuma C., Nagase H., Sora I., Uhl G. R., Cheng E. Y., Tseng L. F., Neuroscience, 94, 203-207 (1999).
8. Roques B. P., Noble F., Dauge V., Fournie-Zaluski M. C., Beaumont A., Pharmacol. Rev., 45, 87-146 (1993).
9. Sakurada C., Sakurada S., Hayashi T., Katsuyama S., Tan-No K., Sakurada T., Biochem. Pharmacol., 66, 653-661 (2003).
10. Smith R. R., Martin-Schild S., Kastin A. J., Zadina J. E. Neuroscience, 105, 773-778 (2001).