Functional up-regulation of basolateral Na+-dependeut HCO 3- transporter NBCn1 in medullary thick ascending limb of K+-depleted rats

Pflugers Archiv European Journal of Physiology

Volumn 448, Issue 6, 2004, Pages 571-578

  Jakobsen, Jakob K ^a   Odgaard, Elvin ^a   Wang, Weidong ^a   Elkjaer, Marie Louise ^a   Nielsen, Søren ^a   Aalkjaer, Christian ^a   Leipziger, Jens ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

Intracellular pH; mTAL; NBC; Perfused tubule

Indexed keywords

AMMONIA; BICARBONATE; BICARBONATE SODIUM COTRANSPORTER; BUFFER; POTASSIUM ION; PROTEIN NBCN1; SODIUM ION; UNCLASSIFIED DRUG;

ALKALINIZATION; AMMONIA FORMATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASOLATERAL MEMBRANE; CONTROLLED STUDY; FEMALE; HYPOKALEMIA; IMMUNOBLOTTING; KIDNEY MEDULLA; KIDNEY PROXIMAL TUBULE; METABOLIC ACIDOSIS; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRANSCYTOSIS;

ANIMALS; BICARBONATES; BLOTTING, WESTERN; DIET; FEMALE; IMMUNOHISTOCHEMISTRY; KIDNEY MEDULLA; LOOP OF HENLE; POTASSIUM; QUATERNARY AMMONIUM COMPOUNDS; RATS; RATS, WISTAR; SODIUM-BICARBONATE SYMPORTERS; UP-REGULATION;

EID: 4644361175     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00424-004-1303-4     Document Type: Article

References (25)

1. +-coupled base transport mechanisms in rat MTALH. Am J Physiol 282:F655-F668
2. Choi I, Aalkjaer C, Boulpaep EL, Boron WF (2000) An electroneutral sodium/bicarbonate cotransporter NBCn1 and associated sodium channel. Nature 405:571-575
3. Elkjaer ML, Kwon TH, Wang W, Nielsen J, Knepper MA, Frokiaer J, Nielsen S (2002) Altered expression of renal NHE3, TSC, BSC-1, and ENaC subunits in potassium-depleted rats. Am J Physiol 283:F1376-F1388
4. Frische S, Zolotarev AS, Kim YH, Praetorius J, Alper S, Nielsen S, Wall SM (2004) AE2 isoforms in rat kidney: immunohistochemical localization and regulation in response to chronic NH4Cl loading. Am J Physiol 286:F1163-F1170
5. Garella S, Chang B, Kahn SI (1979) Alterations of hydrogen ion homeostasis in pure potassium depletion: studies in rats and dogs during the recovery phase. J Lab Clin Med 93:321-331
6. Good DW (1985) Sodium-dependent bicarbonate absorption by cortical thick ascending limb of rat kidney. Am J Physiol 248: F821-F829
7. + intake. Am J Physiol 258:F1345-F1353
8. Good DW (1994) Ammonium transport by the thick ascending limb of Henle's loop. Annu Rev Physiol 56:623-647
9. + exchange in rat medullary thick ascending limb. Am J Physiol 270:F691-F699
10. Greger R (1985) Ion transport mechanisms in thick ascending limb of Henle's loop of mammalian nephron. Physiol Rev 65:760-797
11. Greger R, Hampel W (1981) A modified system for in vitro perfusion of isolated renal tubules. Pflugers Arch 389:175-176
12. Jaeger P, Karlmark B, Giebisch G (1983) Ammonium transport in rat cortical tubule: relationship to potassium metabolism. Am J Physiol 245:F593-F600
13. Kaufman AM, Kahn T (1988) Potassium-depletion alkalosis in the rat. Am J Physiol 255:F763-F770
14. - symporter regulate intracellular pH in mouse medullary thick limbs of Henle. Am J Physiol 258: F445-F456
15. 3 cotransporters NBCn1 and NBC3 but not NBC1. Am J Physiol 282:F341-F351
16. Laghmani K, Richer C, Borensztein P, Paillard M, Froissart M (2001) Expression of rat thick limb Na/H exchangers in potassium depletion and chronic metabolic acidosis. Kidney Int 60:1386-1396
17. - influx in rat medullary thick ascending limb. J Physiol (Lond) 555:205-218
18. Roos A, Boron WF (1981) Intracellular pH. Physiol Rev 61:296-434
19. + antiporters in mouse medullary thick ascending limbs. Am J Physiol 262:F241-F247
20. Tannen RL, McGill J (1976) Influence of potassium on renal ammonia production. Am J Physiol 231:1178-1184
21. Thomas JA, Buchsbaum RN, Zimniak A, Racker E (1979) Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ. Biochemistry 18:2210-2218
22. - cotransporter in rat kidney. Am J Physiol 279:F901-F909
23. + exchange in rat medullary thick ascending limb. pH-dependence and inhibition by hyperosmolality. J Biol Chem 269:20250-20255
24. Weiner ID, Hamm LL (1989) Use of fluorescent dye BCECF to measure intracellular pH in cortical collecting tubule. Am J Physiol 256:F957-F964
25. Wright PA, Burg MB, Knepper MA (1990) Microdissection of kidney tubule segments. Methods Enzymol 191:226-231