Identification and structural ramifications of a hinge domain in apolipoprotein A-I discoidal high-density lipoproteins of different size

Biochemistry

Volumn 43, Issue 37, 2004, Pages 11717-11726

  Maiorano, J Nicholas ^a   Jandacek, Ronald J ^a   Horace, Erica M ^a   Davidson, W Sean ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; LIPIDS; MUTAGENESIS; PARTICLE SIZE ANALYSIS;

HIGH-DENSITY LIPOPROTEIN (HDL); HINGE DOMAIN; RAMIFICATIONS; SUBSPECIES;

PROTEINS;

APOLIPOPROTEIN A1; COMPLEMENTARY DNA; HIGH DENSITY LIPOPROTEIN;

AMINO ACID SEQUENCE; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; ESCHERICHIA COLI; FLUORESCENCE SPECTROSCOPY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; MUTAGENESIS; NONHUMAN; PARTICLE SIZE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL;

ACRYLAMIDE; AMINO ACID SEQUENCE; ANIMALS; APOLIPOPROTEIN A-I; HUMANS; LIPOPROTEINS, HDL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PARTICLE SIZE; PROTEIN CONFORMATION; SPIN LABELS; TRYPTOPHAN;

ESCHERICHIA COLI;

EID: 4644356941     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0496642     Document Type: Article

References (45)

1. Shore, B., and Shore, V. (1969) Isolation and characterization of polypeptides of human serum lipoproteins. Biochemistry 8, 4510-4516.
2. Segrest, J. P., Jackson, R. L., Morrisett, J. D., and Gotto, A. M. J. (1974) A molecular theory of lipid-protein interactions in the plasma lipoproteins. FEBS Lett. 38, 247-258.
3. Brouillette, C. G., and Anantharamaiah, G. M. (1995) Structural models of human apolipoprotein A-I. [Review]. Biochim. Biophys. Acta 1256, 103-129.
4. Borhani, D. W., Rogers, D. P., Engler, J. A., and Brouillette, C. G. (1997) Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation. Proc. Natl. Acad. Sci. U.S.A. 94, 12291-12296.
5. Phillips, J. C., Wriggers, W., Li, Z., Jonas, A., and Schulten, K. (1997) Predicting the structure of apolipoprotein A-I in reconstituted high-density lipoprotein disks. Biophys. J. 73, 2337-2346.
6. Segrest, J. P., Jones, M. K., Klon, A. E., Sheldahl, C. J., Hellinger, M., De Loof, H., and Harvey, S. C. (1999) A detailed molecular belt model for apolipoprotein A-I in discoidal high-density lipoprotein. J. Biol. Chem. 274, 31755-31758.
7. Klon, A. E., Segrest, J. P., and Harvey, S. C. (2002) Comparative models for human apolipoprotein A-I bound to lipid in discoidal high-density lipoprotein particles. Biochemistry 41, 10895-10905.
8. Cheung, M. C., Segrest, J. P., Albers, J. J., Cone, J. T., Brouillette, C. G., Chung, B. H., Kashyap, M., Glasscock, M. A., and Anantharamaiah, G. M. (1987) Characterization of high-density lipoprotein subspecies: structural studies by single vertical spin ultracentrifugation and immunoaffinity chromatography. J. Lipid Res. 28, 913-929.
9. Castro, G. R., and Fielding, C. J. (1988) Early incorporation of cell-derived cholesterol into pre-beta-migrating high-density lipoprotein. Biochemistry 27, 25-29.
10. Wang, N., Silver, D. L., Thiele, C., and Tall, A. R. (2001) Atp-binding cassette transporter a1 (abca1) functions as a cholesterol efflux regulatory protein. J. Biol. Chem. 276, 23742-23747.
11. Jonas, A., Zorich, N. L., Kezdy, K. E., and Trick, W. E. (1987) Reaction of discoidal complexes of apolipoprotein A-I and various phosphatidylcholines with lecithin cholesterol acyltransferase. Interfacial effects. J. Biol. Chem. 262, 3969-3974.
12. Brouillette, C. G., Jones, J. L., Ng, T. C., Kercret, H., Chung, B. H., and Segrest, J. P. (1984) Structural studies of apolipoprotein A-I/phosphatidylcholine recombinants by high-field proton NMR, nondenaturing gradient gel electrophoresis, and electron microscopy. Biochemistry 23, 359-367.
13. Jonas, A., Kezdy, K. E., and Wald, J. H. (1989) Defined apolipoprotein A-I conformations in reconstituted high-density lipoprotein discs. J. Biol. Chem. 264, 4818-4824.
14. Kunitake, S. T., Chen, G. C., Kung, S. F., Schilling, J. W., Hardman, D. A., and Kane, J. P. (1990) Pre-beta high-density lipoprotein. Unique disposition of apolipoprotein A-I increases susceptibility to proteolysis. Arteriosclerosis 10, 25-30.
15. Dalton, M. B., and Swaney, J. B. (1993) Structural and functional domains of apolipoprotein A-I within high-density lipoproteins. J. Biol. Chem. 268, 19274-19283.
16. Calabresi, L., Meng, Q. H., Castro, G. R., and Marcel, Y. L. (1993) Apolipoprotein A-I conformation in discoidal particles: evidence for alternate structures. Biochemistry 32, 6477-6484.
17. Curtiss, L. K., Bonnet, D. J., and Rye, K. A. (2000) The conformation of apolipoprotein A-I in high-density lipoproteins is influenced by core lipid composition and particle size: a surface plasmon resonance study. Biochemistry 39, 5712-5721.
18. Davidson, W. S., Arnvig-McGuire, K., Kennedy, A., Kosman, J., Hazlett, T. L., and Jonas, A. (1999) Structural organization of the N-terminal domain of apolipoprotein A-I: studies of tryptophan mutants. Biochemistry 38, 14387-14395.
19. Panagotopulos, S. E., Witting, S. R., Horace, E. M., Nicholas, M. J., and Sean, D. W. (2002) Bacterial expression and characterization of mature apolipoprotein A-I. Protein Expr. Purif. 25, 353-361.
20. Maiorano, J. N., and Davidson, W. S. (2000) The orientation of helix 4 in apolipoprotein A-I-containing reconstituted high-density lipoproteins. J. Biol. Chem. 275, 17374-17380.
21. Sokoloff, L., and Rothblat, G. H. (1974) Sterol to phospholipid molar ratios of L cells with qualitative and quantitative variations of cellular sterol. Proc. Soc. Exp. Biol. Med. 146, 1166-1172.
22. Davidson, W. S., Rodrigueza, W. V., Lund-Katz, S., Johnson, W. J., Rothblat, G. H., and Phillips, M. C. (1995) Effects of acceptor particle size on the efflux of cellular free cholesterol. J. Biol. Chem. 270, 17106-17113.
23. Markwell, M. A., Haas, S. M., Bieber, L. L., and Tolbert, N. E. (1978) A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal. Biochem. 87, 206-210.
24. Sparks, D. L., Lund-Katz, S., and Phillips, M. C. (1992) The charge and structural stability of apolipoprotein A-I in discoidal and spherical recombinant high-density lipoprotein particles. J. Biol. Chem. 267, 25839-25847.
25. Davidson, W. S., Hazlett, T., Mantulin, W. W., and Jonas, A. (1996) The role of apolipoprotein AI domains in lipid binding. Proc. Natl. Acad. Sci. U.S.A. 93, 13605-13610.
26. Lehrer, S. S. (1971) Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. Biochemistry 10, 3254-3263.
27. Panagotopulos, S. E., Horace, E. M., Maiorano, J. N., and Davidson, W. S. (2001) Apoliprotein A-I adopts a belt-like orientation in reconstituted high density lipoproteins. J. Biol. Chem. 276, 42965-42970.
28. Matz, C. E., and Jonas, A. (1982) Reaction of human lecithin cholesterol acyltransferase with synthetic micellar complexes of apolipoprotein A-I, phosphatidylcholine, and cholesterol. J. Biol. Chem. 257, 4541-4546.
29. Nichols, A. V., Gong, E. L., Blanche, P. J., Forte, T. M., and Shore, V. G. (1984) Interaction of model discoidal complexes of phosphatidylcholine and apolipoprotein A-I with plasma components. Physical and chemical properties of the transformed complexes. Biochim. Biophys. Acta 793, 325-337.
30. Gilardi, G., Mei, G., Rosato, N., Canters, G. W., and Finazzi-Agro, A. (1994) Unique environment of Trp48 in Pseudomonas aeruginosa azurin as probed by site-directed mutagenesis and dynamic fluorescence spectroscopy. Biochemistry 33, 1425-1432.
31. Sorci-Thomas, M. G., Curtiss, L., Parks, J. S., Thomas, M. J., Kearns, M. W., and Landrum, M. (1998) The hydrophobic face orientation of apolipoprotein A-I amphipathic helix domain 143-164 regulates lecithin: cholesterol acyltransferase activation. J. Biol. Chem. 273, 11776-11782.
32. Sorci-Thomas, M. G., Curtiss, L., Parks, J. S., Thomas, M. J., and Kearns, M. W. (1997) Alteration in apolipoprotein A-I 22-mer repeat order results in a decrease in lecithin: cholesterol acyltransferase reactivity. J. Biol. Chem. 272, 7278-7284.
33. Jonas, A. (1998) Regulation of lecithin cholesterol acyltransferase activity. Prog. Lipid Res. 37, 209-234.
34. Corsico, B., Toledo, J. D., and Garda, H. A. (2001) Evidence for a central apolipoprotein A-I domain loosely bound to lipids in discoidal lipoproteins that is capable of penetrating the bilayer of phospholipid vesicles. J. Biol. Chem. 276, 16978-16985.
35. Segrest, J. P. (1977) Amphipathic helixes and plasma lipoproteins: thermodynamic and geometric considerations. Chem. Phys. Lipids 18, 7-22.
36. Wlodawer, A., Segrest, J. P., Chung, B. H., Chiovetti, R. J., and Weinstein, J. N. (1979) High-density lipoprotein recombinants: evidence for a bicycle tire micelle structure obtained by neutron scattering and electron microscopy. FEBS Lett. 104, 231-235.
37. Koppaka, V., Silvestro, L., Engler, J. A., Brouillette, C. G., and Axelsen, P. H. (1999) The structure of human lipoprotein A-I. Evidence for the "belt" model. J. Biol. Chem. 274, 14541-14544.
38. Li, H., Lyles, D. S., Thomas, M. J., Pan, W., and Sorci-Thomas, M. G. (2000) Structural determination of lipid-bound ApoA-I using fluorescence resonance energy transfer. J. Biol. Chem. 275, 37048-37054.
39. Davidson, W. S., and Hilliard, G. M. (2003) The spatial organization of apolipoprotein A-I on the edge of discoidal high-density lipoprotein particles. J. Biol. Chem. 278, 27199-27207.
40. Jonas, A., Wald, J. H., Toohill, K. L., Krul, E. S., and Kezdy, K. E. (1990) Apolipoprotein A-I structure and lipid properties in homogeneous, reconstituted spherical and discoidal high-density lipoproteins. J. Biol. Chem. 265, 22123-22129.
41. Li, H. H., Lyles, D. S., Pan, W., Alexander, E., Thomas, M. J., and Sorci-Thomas, M. G. (2002) ApoA-I structure on discs and spheres. Variable helix registry and conformational states. J. Biol. Chem. 277, 39093-39101.
42. Klon, A. E., Segrest, J. P., and Harvey, S. C. (2002) Molecular dynamics simulations on discoidal HDL particles suggest a mechanism for rotation in the apo A-I belt model. J. Mol. Biol. 324, 703-721.
43. Segrest, J. P., De Loof, H., Dohlman, J. G., Brouillette, C. G., and Anantharamaiah, G. M. (1990) Amphipathic helix motif: classes and properties. Proteins 8, 103-117.
44. Roberts, L. M., Ray, M. J., Shin, T. W., Hayden, E., Reader, M. M., and Brouillette, C. G. (1997) Structural analysis of apolipoprotein A-I: limited proteolysis of methionine-reduced and -oxidized lipid-free and lipid-bound human apo A-I. Biochemistry 36, 7615-7624.
45. Sparks, D. L., and Phillips, M. C. (1992) Quantitative measurement of lipoprotein surface charge by agarose gel electrophoresis, J. Lipid Res. 33, 123-130.