The role of peripheral chemoreceptor activity on the respiratory responses to hypoxia and hypercapnia in anaesthetised rabbits with induced hypothyroidism

Chinese Journal of Physiology

Volumn 47, Issue 3, 2004, Pages 153-159

  Simsek, Gonul ^a   Yelmen, Nermin Karaturan ^a   Guner, Ibrahim ^a   Sahin, Gulderen ^a   Oruc, Tulin ^a   Karter, Yesari ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Hypercapnia; Hypothyroidism; Peripheral chemoreceptors; Respiratory pattern

Indexed keywords

CARBON DIOXIDE; IODIDE; LIOTHYRONINE; NITROGEN; OXYGEN; THIAMAZOLE; THYROTROPIN; THYROXINE;

AIR; ANESTHESIOLOGICAL TECHNIQUES; ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL MODEL; AORTA CHEMORECEPTOR; ARTERIAL PRESSURE; AUTONOMIC DENERVATION; BREATHING RATE; CARBON DIOXIDE TENSION; CONTROLLED STUDY; FEMALE; HYPERCAPNIA; HYPOTHYROIDISM; HYPOXIA; LUNG MINUTE VOLUME; MALE; NONHUMAN; OXYGEN TENSION; PH; RABBIT; RESPIRATION CONTROL; REVIEW; STATISTICAL SIGNIFICANCE; TIDAL VOLUME;

EID: 4644352908     PISSN: 03044920     EISSN: 26660059     Source Type: Journal    
DOI: None     Document Type: Review

References (24)

1. Coates, E.L., Li, A. and Nattie, E.E. Widespread sites of brain stem ventilatory chemoreceptors. J. Appl. Physiol. 75: 5-14, 1993.
2. Cream, C.L., Li, A. and Nattie, E.E. RTN TRH causes prolonged respiratory stimulation. J. Appl. Physiol. 83: 792-799, 1997.
3. Dariyerli, N., Andican, G., Çatakoglu, A.B., Hatemi, H. and Burçak, G. Hyperuricemia in hypothyroidism: Is it associated with post-insulin infusion glycemic response? Tohoku J. Exp. Med. 199:59-68, 2003.
4. Duranti, R., Gheri, R.G., Gorini, M., Gigliotti, F., Spinelli, A., Fanelli, A. and Scano, G. Control of breathing in patients with severe hypothyroidism. Am. J. Med. 95: 29-37, 1993.
5. Güner, I., Yelmen, N., Sahin, G. and Oruc, T. The effect of intracerebroventricular dopamine administration on the respiratory response to hypoxia. Tohoku J. Exp. Med. 196: 219-230, 2002.
6. Iannuzzo, C.O., Chen, V., O'Brien, P. and Keens, T.G. Effect of experimental dysthyroidism on the enzymatic character of the diaphragm. J. Appl. Physiol. 56: 117-121, 1984.
7. Karaturan, Y.N., Sabin, G., Oruc, T. and Hacibekiroglu, M. Hypoxic initiation of pulmonary hypertension is mediated by serotonin secretion from neuroepithelial bodies in chemodenervated dogs. Chinese J. Physiol. 46: 27-33, 2003.
8. Khaleeli, A.A., Griffith, D.G. and Edwards, R.H. The clinical presentation of hypothyroid myopathy and its relationship to abnormalites in structure and function of skeletal muscles. Clin. Endocrinol (Oxf). 19: 365-376, 1983.
9. Kragie, L. and Smiehorowski, R. Measures of skeletal muscle calcium channels and acetlycholine receptors in thyroidectomized rats. Endocr. Res. 19: 207-219, 1993.
10. Ladenson, P.W., Goldenheim, P.D. and Ridgwaey, E.C. Predietian and reversal of blunted ventilatory responsiveness in patients with hypothyroidism. Am. J. Med. 84: 877-883, 1988.
11. Laroche, C.M., Cairns, T., Moxham, I. and Green, M. Hypothyroidism presenting with expiratory muscle weakness. Am. Rev. Respir. 138: 472-474, 1988.
12. Li, A., Eugene, E. and Nattie, E.E. Prolonged stimulation of respiration by brain stem metabotropic glutamate receptors. J. Appl. Physiol. 79: 1650-1656, 1995.
13. Martinez, F.J., Bermudez-Gomez, M. and Celli, B.R. Hypothyroidism. A reversible cause of diaphragmatic dysfunction. Chest 96: 1059-1063, 1989.
14. Massumi, R.A. and Winnacker, J.L. Severe depression of the respiratory center in myxedema. Am. J. Med. 36: 876-882, 1964.
15. McCown, T.J., Hedner, I., Towle, A., Breese, G. and Mueller, R. Brainstem localization of a thyrotropin releasing hormone induced change in respiratory function. Brain Res. 373: 189-196, 1986.
16. Oruc, T. The activation of the central and peripheral respiratory control mechanism in hyperoxia and hypoxia. Bull. Europ. Physiopath. Resp. Suppl. 18: 113, 1982.
17. Oruc, T., Terzioglu, M., Sahin, G. and Dursun, S. Response of the central respiratory control mechanisms to hyperoxia and hypoxia. Bull. Europ. Physiopath. Resp. 18: 439-447, 1982.
18. Pearce, R., Stometta, R. and Guyenet, P. Retrotrapezoid nucleus in the rat. Neurocsi. Lett. 101: 138-142, 1989.
19. Rekling, J.E., Champagnat, I. and Denavit-Saubie, M. Thyrotropin-releasing hormone (TRH) depolarizes a subset of inspiratory neurons in the newbom mouse brain stem in vitro. J. Neurophysiol. 75:811-819, 1996.
20. Simsek, G., Andican, G., Karakoc, Y., Yigit, G., Hatemi, H. and Candan,G. Calcium, magnesium and zinc status in experimental hypothyroidism. Biol. Trace Element Res. 60: 205-213, 1997.
21. Simsek, G. Karaturan, N., Sabin, G. Oruc, T. and Hatemi, H. Respiratory responses to hypoxia and hypercapnia in anaesthetised rabbits with induced hypothyroidism. Med. Sci. Res. 24: 635-637, 1996.
22. Sabin, G. and Terzioglu, M. The influence of chronic hypoxia on erythrocyte 2,3 diphospho glycerate and the sensitivity of peripheral chemoreceptors of rabbits. Cerrahpasa Med. Review. 4: 46-56, 1985.
23. Wilson, W.R. and Bedell, G.N. The pulmonary abnormalities in myxedema. J. Clin. Invest. 39: 42-55, 1960.
24. ZwilIich, C.W., Pierson, D.J., Hofeldt, F.D., Lufkin, E.G. and Weil, I.V. Ventilatory control in myxedema and hypothyroidism. N. Eng. J. Med. 292: 662-665, 1975.