Transtympanic perfusion: Indications and limitations

Current Opinion in Otolaryngology and Head and Neck Surgery

Volumn 12, Issue 5, 2004, Pages 378-383

  Light, Joshua P ^a   Silverstein, Herbert ^b  

^a Palm Beach ENT   (United States)

^b Ear Research Foundation   (United States)

Author keywords

Dexamethasone; Gentamicin; Inner ear perfusion; Meniere; Sudden hearing loss; Transtympanic; Vertigo

Indexed keywords

DEXAMETHASONE; GENTAMICIN; STEROID;

AUTOIMMUNE DISEASE; DRUG CONTRAINDICATION; DRUG DELIVERY SYSTEM; ENDOLYMPH; HUMAN; INNER EAR DISEASE; LABYRINTHECTOMY; MENIERE DISEASE; PERCEPTION DEAFNESS; PERFUSION; PRIORITY JOURNAL; REVIEW; TINNITUS; TRANSTYMPANIC PERFUSION; VERTIGO; VESTIBULAR NERVE;

EID: 4644347357     PISSN: 10689508     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.moo.0000134438.91734.38     Document Type: Review

References (37)

1. Schuknecht HF: Ablation therapy for relief of Meniere's disease. Laryngoscope 1956, 66:859-870.
2. Jackson LE, Silverstein H: Chemical perfusion of the inner ear. Otolaryngol Clin North Am 2002, 35:639-653. Review of inner ear perfusion including surgical techniques as well as the basic science behind perfusion via the round window membrane.
3. Silverstein H, Jackson LE, Rosenberg SI: Silverstein MicroWick for the treatment of inner ear disease. Oper Tech Otolaryngol Head Neck Surg 2001, 12:44-47.
4. Plontke SK, Wood AW, Salt AN: Analysis of gentamicin kinetics in fluids of the inner ear with round window administration. Otol Neurotol 2002, 23:967-974.
5. Chelikh L, Teixeira M, Martin C, et al.: High variability of perilymphatic entry of neutral molecules through the round window. Acta Otolaryngol 2003, 123:199-202.
6. Silverstein H, Rowan PT, Olds MJ, et al.: Inner ear perfusion and the role of round window patency. Am J Otol 1997, 18:540-543.
7. Becvarovski Z, Bojrab DI, Michaelides EM, et al.: Round window gentamicin absorption: an in vivo human model. Laryngoscope 2002, 112:1610-1613.
8. Chandrasekhar SS: Intratympanic dexamethasone for sudden sensorineural hearing loss: clinical and laboratory evaluation. Otol Neurotol 2001, 22:18-23. Animal study comparing systemic administration to inner ear perfusion, shows enhanced drug delivery via transtympanic delivery.
9. Beck C, Schmidt CL: 10 years experience with intratympanically applied streptomycin (gentamicin) in the therapy of Morbus Meniere. Arch Otorhinolaryngol 1978, 221:149-152.
10. Nedzelski JM, Schessel DA, Bryce GE, et al.: Chemical labyrinthectomy: local application of gentamicin for the treatment of unilateral Meniere's disease. Am J Otol 1992, 13:18-22.
11. Hoffer ME, Kopke RD, Weisskopf P, et al.: Microdose gentamicin administration via the round window microcatheter: results in patients with Meniere's disease. Ann N Y Acad Sci 2001, 942:46-51.
12. Light JP, Silverstein H, Jackson LE: Gentamicin perfusion, vestibular response and hearing loss. Otol Neurotol 2003, 24:294-298. Study analyzing the relationship between vestibular ablation, vertigo control, and hearing preservation. Attempts to answer what is the optimal end point of treatment.
13. Diamond C, O'Connell DA, Hornig JD, et al.: Systematic review of intratympanic gentamicin in Meniere's disease. J Otolaryngol 2003, 32:351-361. Good meta analysis of gentamicin treatment in the management of Meniere disease.
14. Hillman TA, Chen DA, Arriaga MA: Vestibular nerve section versus intratympanic gentamicin for Meniere's disease. Laryngoscope 2004, 114:216-222.
15. Obholzer RJ, Wareing MJ: Intratympanic gentamicin for Meniere's disease; a survey of current UK practice. J Laryngol Otol 2003, 117:459-461.
16. Martin E, Perez N: Hearing loss after intratympanic gentamicin therapy for unilateral Meniere's Disease. Otol Neurotol 2003, 24:800-806.
17. Shea JJ Jr: The role of dexamethasone or streptomycin perfusion in the treatment of Meniere's disease. Otolaryngol Clin North Am 1997, 30:1051-1059.
18. DeKleyn A: Sudden complete or partial loss of function of the octavus-system in apparently normal persons. Acta Otolaryngol 1944, 32:407-429.
19. Byl FM, Freeman MA, Haberkamp TJ, et al.: Sudden sensorinueral hearing loss. Otolaryngol Clin North Am 1996, 29:393-405.
20. Byl FM Jr: Sudden hearing loss: eight years' experience and suggested prognostic table. Laryngoscope 1984, 94:647-661.
21. Mattox DE, Simmons FB: Natural history of sudden sensorineural hearing loss. Ann Otol Rhinol Laryngol 1977, 86:463-480.
22. Jaffe BF: Viral causes of sudden inner ear deafness. Otolaryngol Clin North Am 1978, 11:63-69.
23. Schuknecht HF, Kimura RS, Naufal PM: The pathology of sudden deafness. Acta Otolaryngol 1973, 76:75-97.
24. Westerlaken BO, Stokroos RJ, Dhooge IJ, et al.: Treatment of idiopathic sudden sensorineural hearing loss with antiviral therapy: a prospective, randomized, double-blind clinical trial. Ann Otol Rhinol Laryngol 2003, 112:993-1000.
25. Uri N, Doweck I, Cohen-Kerem R, et al.: Acyclovir in the treatment of idiopathic sudden sensorineural hearing loss. Otolaryngol Head Neck Surg 2003, 128:544-549.
26. Wilson WR, Byl FM, Laird N: The efficacy of steroids in the treatment of idiopathic sudden hearing loss. A double-blind clinical study. Arch Otolaryngol 1980, 106:772-776.
27. Alexiou C, Arnold W, Fauser C, et al.: Sudden sensorineural hearing loss: does application of glucocorticoids make sense? Arch Otolaryngol Head Neck Surg 2001, 127:253-258.
28. Chen CY, Halpin C, Rauch SD: Oral steroid treatment of sudden sensorineural hearing loss: a ten year retrospective analysis. Otol Neurotol 2003, 24:728-733. Excellent review of large number of patients with SSNHL and their response to treatment with steroids.
29. Haberkamp TJ, Tanyeri HM: Management of idiopathic sudden sensorineural hearing loss. Am J Otol 1999, 20:587-592.
30. Parnes LS, Sun AH, Freeman DJ: Corticosteroid pharmacokinetics in the inner ear fluids: an animal study followed by clinical application. Laryngoscope 1999, 109:1-17.
31. Gianoli GJ, Li JC: Transtympanic steroids for treatment of sudden hearing loss. Otolaryngol Head Neck Surg 2001, 125:142-146.
32. Kopke R, Hoffer M, Wester D, et al.: Targeted topical steroid therapy in sudden sensorineural hearing loss. Otol Neurotol 2001, 22:475-479.
33. Silverstein H, Light JP, Jackson LE, et al.: Dexamethasone inner ear perfusion for the treatment of sudden deafness. Presented at Amer Acad Otolaryngol Head Neck Surg Annual Meeting. San Diego, CA: September 2002.
34. Hillman TM, Arriaga MA, Chen DA: Intratympanic steroids: do they acutely improve hearing in cases of cochlear hydrops? Laryngoscope 2003, 113:1903-1907.
35. Yang GS, Song HT, Keithley EM, et al.: Intratympanic immunosuppressives for prevention of immune-mediated sensorineural hearing loss. Am J Otol 2000, 21:499-504.
36. Silverstein H, Durand B, Jackson LE, et al.: Use of the maleus handle as a landmark for localization of the round window membrane. Ear Nose Throat J 2001, 80:444-448.
37. Silverstein H, Lewis WB, Jackson LJ, et al.: Changing trends in the surgical treatment of Meniere's disease: results of a 10-year study. Ear Nose Throat J 2003, 82:185-194.