Absence of NK1 receptors in human blood lymphocytes and granulocytes

Neuropsychobiology

Volumn 50, Issue 3, 2004, Pages 221-225

  Marazziti, Donatella ^a   Giannaccini, Gino ^a   Baroni, Stefano ^a   Betti, Laura ^a   Giusti, Laura ^a   Lucacchini, Antonio ^a   Cassano, Giovanni B ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

3H SR140333; 125I BHSP; Granulocytes; Human blood; Lymphocytes; NK1 receptors; Rat cerebral cortex; Substance P

Indexed keywords

BOLTON HUNTER REAGENT I 125; CELL NUCLEUS RECEPTOR; NOLPITANTIUM; ANTIDEPRESSANT AGENT; DIAGNOSTIC AGENT; DRUG DERIVATIVE; NEUROKININ 1 RECEPTOR; PIPERIDINE DERIVATIVE; QUINUCLIDINE DERIVATIVE; SUBSTANCE P; SUBSTANCE P, SAR(9) MET(O2)(11); SUBSTANCE P, SAR(9)-MET(O2)(11)-;

ADULT; ARTICLE; BINDING AFFINITY; BLOOD CELL; BRAIN CORTEX; CONTROLLED STUDY; FEMALE; GRANULOCYTE; HUMAN; HUMAN EXPERIMENT; LYMPHOCYTE; MALE; MOLECULAR DYNAMICS; NORMAL HUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; ANIMAL; COMPARATIVE STUDY; MENTAL STRESS; METABOLISM; PHYSIOLOGY; RAT; STEREOISOMERISM;

ADULT; ANIMALS; ANTIDEPRESSIVE AGENTS; CEREBRAL CORTEX; FEMALE; GRANULOCYTES; HUMANS; LYMPHOCYTES; MALE; PIPERIDINES; QUINUCLIDINES; RATS; RECEPTORS, NEUROKININ-1; STEREOISOMERISM; STRESS, PSYCHOLOGICAL; SUBSTANCE P;

EID: 4644347302     PISSN: 0302282X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000079974     Document Type: Article

References (30)

1. Von Euler US, Gaddum JH: An unidentified depressor substance in certain tissue extracts. J Physiol 1931;72:74-87.
2. Nakanishi S: Mammalian tachykinin receptors. Annu Rev Neurosci 1991;14:123-136.
3. Khawaja AM, Rogers DF: Tachykinins: Receptor to effector. Int J Biochem Cell Biol 1996;28:721-738.
4. Sagan S, Chassaing G, Pradier L, Lavielle S: Tachykinin peptides affect differently the second messenger pathways after binding to CHO-expressed human NK-1 receptors. J Pharmacol Exp Ther 1996;276:1039-1048.
5. Kramer MS, Cutler N, Shrivastava R, Carman J, Srmek JJ, Reines SA, Liu G, Snavely D, Wyatt-Knowels E, Hale JJ, Millis SG, MacCoss M, Swain CJ, Harrison T, Hill RG, Hefti F, Scolnick EM, Cascieri MA, Chicchi GG, Sadowski S, Williams AR, Hewson L, Smith D, Rupniak NM: Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science 1998;281:1640-1645.
6. Rupniak NM: New insights into the antidepressant actions of substance P (NK1 receptor) antagonists. Can J Physiol Pharmacol 2002;80:489-494.
7. Rimon R, Le Greves P, Nyberg F, Heikkila L, Salmela L, Terenius L: Elevation of substance P-like peptide in the CSF of psychiatric patients. Biol Psychiatry 1984;19:509-516.
8. Berrettini WH, Rubinow DR, Nurnberger JI Jr, Simmons-Alling S, Post RM, Gershon ES: CSF substance P immunoreactivity in affective disorders. Biol Psychiatry 1985;20:965-970.
9. Kleinman JE, Hong J, Iadarola M, Govoni S, Gillin J: Neuropeptides in human brain postmortem studies. Prog Neuropsychopharmacol Biol Psychiatry 1985;9:91-95.
10. Miller C, Kirchmair R, Troger J, Saria A, Fleischhacker WW, Fischer-Colbrie R, Benzer A, Winkler H: CSF of neuroleptic-naive first-episode schizophrenic patients: Levels of biogenic amines, substance P, and peptides derived from chromogranin A (GE-25) and secretogranin II (secretoneurin). Biol Psychiatry 1989;1:911-918.
11. Heikkila L, Rimon R, Terenius L: Dynorphin A and substance P in the cerebrospinal fluid of schizophrenic patients. Psychiatry Res 1990; 34: 229-236.
12. Marazziti D, Rossi A, Giannaccini G, Baroni S, Lucacchini A, Cassano GB: Presence and characterization of the serotonin transporter in human resting lymphocytes. Neuropsychopharmacology 1998;19:154-159.
13. Burcher E, Buck SH, Lovenberg W, O'Donohue L: Characterization and autoradiographic localization of multiple tachykinin binding sites in gastrointestinal tract and bladder. J Pharmacol Exp Ther 1986;236:819-831.
14. Campbell VA, Beddy P, Foley A, Bakhle YS, Bell C: Reduced inflammation in genetically hypertensive rat airways is associated with reduced tachykinin NK1 receptor numbers. Eur J Pharmacol 2000;401:109-114.
15. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-275.
16. Mazzone SB, Hinrichsen CF, Geraghty DP: Substance P receptors in brain stem respiratory centers of the rat: Regulation of NK1 receptors by hypoxia. J Pharmacol Exp Ther 1997;282:1547-1556.
17. Beaujouan JC, Saffroy M, Torrens Y, Glowinski J: Different subtypes of tachykinin NK1 receptor binding sites are present in the rat brain. J Neurochem 2000;75:1015-1026.
18. Payan DG, Brewster DR, Goetzel EJ: Stereospecific receptors for substance P on cultured human IM-9 lymphoblasts. J Immunol 1984; 133: 3260-3265.
19. Roberts AI, Taunk J, Ebert EC: Human lymphocytes lack substance P receptors. Cell Immunol 1992; 141: 457-465.
20. Kavelaars A, Broeke D, Jeurissen F, Kardux J, Meijer A, Franklin R, Gelfand EW, Heijnen CJ: Activation of human monocytes via a nonneurokinin substance P receptor that is coupled to Gi protein, calcium, phospholipase D, MAP kinase, and IL-6 production. J Immunol 1994;153:3691-3699.
21. Kavelaars A, Jeurissen F, Heijnen CJ: Substance P receptor and signal transduction in leukocytes. Immunomethods 1994; 5: 41-48.
22. Ho WZ, Lai JP, Zhu XH, Uvaydova M, Douglas SD: Human monocytes and macrophages express substance P and neurokinin-1 receptor. J Immunol 1997;159:5654-5660.
23. Lai JP, Douglas SD, Ho WZ: Human lymphocytes express substance P and its receptor. J Neuroimmunol 1998;86:80-86.
24. Goode T, O'Connell J, Sternini C, Anton P, Wong H, O'Sullivan GC, Collins JK, Douglas SD, Shanahan F: Substance P (neurokinin-1) receptor is a marker of human mucosal but not peripheral mononuclear cells: Molecular quantitation and localization. J Immunol 1998;161:2232-2240.
25. Goode T, O'Connell J, Ho WZ, O'Sullivan GC, Collins JK, Douglas SD, Shanahan F: Differential expression of neurokinin-1 receptor by human mucosal and peripheral lymphoid cells. Clin Diagn Lab Immunol 2000;7:371-376.
26. Camarda V, Rizzi A, Calo G, Guerrini R, Salvadori S, Regoli D: Pharmacological profile of hemokinin 1: A novel member of the tachykinin family. Life Sci 2002;71:363-370.
27. Mantyh PW, Allen CJ, Ghilardi JR, Rogers SD, Mantyh CR, Liu H, Basbaum AJ, Vigna SR, Maggio JE: Rapin endocytosis of a G protein-coupled receptor: Substance P-evoked internalization of its receptor in the rat striatum in vivo. Proc Natl Acad Sci USA 1995;92:2622-2626.
28. Garland AM, Grady EF, Payan DG, Vigna SR, Bunnett N: Agonist-induced internalization of the substance P (NK1) receptor expressed in epithelial cells. Biochem J 1994;303:177-186.
29. 3H] substance P analogues in NK-1 receptor transfected CHO cells. Biochem Biophys Res Commun 2001;282:958-964.
30. Kim HR, Lavielle S, Sagan S: The two NK-1 binding sites are distinguished by one radiolabelled substance P analogue. Biochem Biophys Res Commun 2003;306:725-729.