Substance P (neurokinin-1) receptor is a marker of human mucosal but not peripheral mononulear cells: Molecular quantitation and localization

Journal of Immunology

Volumn 161, Issue 5, 1998, Pages 2232-2240

  Goode, Triona ^a   O'Connell, Joe ^a   Sternini, Catia ^a   Anton, Peter ^a   Wong, Helen ^a   O'Sullivan, Gerald C ^b   Collins, J Kevin ^a   Shanahan, Fergus ^a,c  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University Hospital ^*  (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CD19 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; CELL ANTIGEN; CELL MARKER; MESSENGER RNA; SUBSTANCE P; SUBSTANCE P RECEPTOR;

ARTICLE; COLON MUCOSA; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; LAMINA PROPRIA; LYMPH FOLLICLE; MONONUCLEAR CELL; MUCOSA CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BIOLOGICAL MARKERS; CELL SEPARATION; COLON; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTESTINAL MUCOSA; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE SUBSETS; POLYMERASE CHAIN REACTION; RECEPTORS, NEUROKININ-1; RNA, MESSENGER;

EID: 0032167525     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Stanisz, A. M. 1994. Neuronal factors modulating immunity. Neuroimmunomodulation 1:217.
2. Payan, D. G. 1989. Neuropeptides and inflammation: the role of substance P. Annu. Rev. Med. 40:341.
3. Erspanner, V. 1981. The tachykinin peptide family. Trends Neurosci. 4:267.
4. Pernow, B. 1983. Substance P. Pharmacol. Rev. 35:85.
5. Felten, D. L., S. Y. Felten, D. L. Bellinger, and J. A. Olschowka. 1992. Noradrenergic and peptidergic innervation of lymphoid organs. In Neuroimmunoendocrinology. J. E. Blalock, ed. Karger, Basel, p. 25.
6. Stead, R. H., M. Tomioka, R. H. Riddell, and J. Bienenstock. 1988. Substance P and/or calcitonin gene-related peptide are present in sub-epithelial enteric nerves apposed to intestinal mucosal mast cells. In Inflammatory Bowel Disease: Current Status and Future Approach. R. P. MacDermott, ed. Elsevier, Amsterdam, p. 43.
7. Payan, D. G., D. R. Brewster, and E. J. Goetzl. 1983. Specific stimulation of human T lymphocytes by substance P. J. Immunol. 131:1613.
8. Payan, D. G., and E. J. Goetzl. 1985. Modulation of lymphocyte function by sensory neuropeptides. J. Immunol. 135:783.
9. Stanisz, A. M., D. Befus, and J. Bienenstock. 1986. Differential effects of vasoactive intestinal peptide, substance P and somatostatin on immunoglobulin synthesis and proliferation by lymphocytes from Peyer's patches, mesenteric lymph nodes and spleen. J. Immunol. 136:152.
10. Laurenzi, M. A., M. A. A. Persson, C. J. Dalsgaard, and O. Ringden. 1989. Stimulation of B lymphocyte differentiation by the neuropeptide substance P and neurokinin A. Scand. J. Immunol. 30:695.
11. Pascual, D. W., J. Xu-Amano, H. Kiyono, J. R. McGhee, and K. L. Bost. 1991. Substance P acts directly upon cloned B lymphoma cells to enhance IgA and IgM production. J. Immunol. 146:2130.
12. Ruff, M. R., S. M. Wahl, and C. B. Pert. 1985. Substance P receptor-mediated chemotaxis of human monocytes. Peptides 6:107.
13. Kolasinski, S. L., K. A. Haines, B. N. Cronstein, E. L. Siegel, and S. B. Abramson. 1992. Neuropeptides and inflammation: somatostatin as a selective antagonist of neutrophil activation by substance P. Arthritis Rheum. 35:369.
14. Kähler, C. M., B. A. Sitte, N. Reinisch, and C. J. Wiedermann. 1993. Stimulation of the chemotactic migration of human fibroblasts by substance P. Eur. J. Pharmacol. 249:281.
15. Lowman, M. A., R. C. Benyon, and M. K. Church. 1988. Characterization of neuropeptide-induced histamine release from human dispersed skin mast cells. Br. J. Pharmacol. 95:121.
16. Bar-Shavit, Z., R. Goldman, Y. Stabinsky, P. Gottlieb, M. Fridkin, V. I. Teichberg, and S. Blumberg. 1980. Enhancement of phagocytosis: a newly found activity of substance P residing in its N-terminal tetrapeptide sequence. Biochem. Biophys. Res. Commun. 94:1445
17. Lotz, M., J. H. Vaughan, and D. A. Carson. 1988. Effect of neuropeptides on production of inflammatory cytokines by human monocytes. Science 241:1218.
18. Pascual, D. W., and K. L. Bost. 1990. Substance P production by P388D1 macrophages: a possible autocrine function for this neuropeptide. Immunology 71:52.
19. Metwali, A., A. M. Blum, L. Ferraris, J. S. Klein, C. Fiocchi, and J. V. Weinstock. 1994. Eosinophils within healthy or inflamed human intestine produce substance P and vasoactive intestinal peptide. J. Neuroimmunol. 52:69.
20. Guard, S., and S. P. Watson. 1991. Tachykinin receptor types: classification and membrane signalling mechanisms. Neurochem. Int. 18:149.
21. Nakanishi, S. 1991. Mammalian tachykinin receptors. Annu. Rev. Neurosci. 14:123.
22. Payan, D. G., D. R. Brewster, A. Missirian-Bastian, and E. J. Goetzl. 1984. Substance P recognition by a subset of human T lymphocytes. J. Clin. Invest. 74:1532.
23. Payan, D. G., D. R. Brewster, and E. J. Goetzl. 1984. Stereospecific receptors for substance P on cultured human IM-9 lymphoblasts. J. Immunol. 133:3260.
24. Gates, T. S., R. P. Zimmerman, C. R. Mantyh, S. R. Vigna, J. E. Maggio, M. L. Welton, E. P. Passaro Jr., and P. W. Mantyh. 1989. Substance P and substance K receptor binding sites in the human gastrointestinal tract: localization by autoradiograpby. Peptides 9:1207.
25. Roberts, A. I., J. Taunk, and E. C. Ebert. 1992. Human lymphocytes lack substance P receptors. Cell. Immunol. 141:457.
26. i protein, calcium, phospholipase D, MAP kinase, and IL-6 production. J. Immunol. 153:3691.
27. Kavelaars, A., F. Jeurissen, J. von Frijtag Drabbe Künzel, J. H. van Roijen, G. T. Rijkers, and C. J. Heijnen. 1993. Substance P induces a rise in intracellular calcium concentration in human T lymphocytes in vitro: evidence of a receptor-independent mechanism. J. Neuroimmunol. 42:61.
28. B̊yum, A. 1968. Separation of leukocytes from blood and bone marrow. Scand. J. Clin. Lab. Invest. 21(Suppl. 97):31.
29. Bull, D. M., and M. A. Bookman. 1977. Isolation and functional characterization of human intestinal mucosal lymphoid cells. J. Clin. Invest. 59:966.
30. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156.
31. O'Connell, J., T. Goode, and F. Shanahan. 1997. Quantitative measurement of mRNA expression by competitive RT-PCR. In Methods in Molecular Biology, Vol. 92. S. L. Meltzer, ed. Humana Press, Totowa, p. 183.
32. Piatak, M., Jr., K. Luk, B. Williams, and J. D. Lifson. 1993. Quantitative competitive polymerase chain reaction for accurate quantitation of HIV DNA and RNA species. BioTechniques 14:70.
33. Kavelaars, A., F. Jeurissen, and C. J. Heijnen. 1994. Substance P receptors and signal transduction in leukocytes. ImmunoMethods 5:41.
34. Mantyh, P. W., C. J. Allen, J. R. Ghilardi, S. D. Rogers, C. R. Mantyh, H. Liu, A. I. Basbaum, S. R. Vigna, and J. E. Maggio. 1995. Rapid endocytosis of a G protein-coupled receptor: substance P-evoked internalization of its receptor in the rat striatum in vivo. Proc. Natl. Acad. Sci. USA 92:2622.
35. 1) receptor expressed in epithelial cells. Biochem. J. 303:177.
36. Joslin, G., J. E. Krause, A. D. Hershey, S. P. Adams, R. J. Fallon, and D. H. Perlmutter. 1991. Amyloid-β peptide, substance P, and bombesin bind to the serpin-enzyme complex receptor. J. Biol. Chem. 266:21897.
37. Jensen, R. T., and D. H. Coy. 1991. Progress in the development of potent bombesin receptor antagonists. Trends Pharmacol. Sci. 12:13.
38. Marasco, W. A., H. J. Showell, and E. L. Becker. 1981. Substance P binds to the formylpeptide chemotaxis receptor on the rabbit neutrophil. Biochem. Biophys. Res. Commun. 99:1065.
39. McCormack, R. J., R. P. Hart, and D. Ganea. 1996. Expression of NK-1 receptor mRNA in murine T lymphocytes. Neuroimmunomodulation 3:35.
40. Stanisz, A. M., R. Scicchitano, P. Dazin, J. Bienenstock, and D. G. Payan. 1987. Distribution of substance P receptors on murine Peyer's patch and splenic T and B lymphocytes. J. Immunol. 139:749.
41. Mantyh, C. R., T. S. Gates, R. P. Zimmerman, M. L. Welton, E. P. Passaro Jr., S. R. Vigna, J. E. Maggo, L. Kruger, and P. W. Mantyh. 1988. Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn's disease. Proc. Natl. Acad. Sci. USA 85:3235.
42. Mantyh, P. W., C. R. Mantyh, T. Gates, S. R. Vigna, and J. E. Maggio. 1988. Receptor binding sites for substance P and substance K in the canine gastrointestinal tract and their possible role in inflammatory bowel disease. Neuroscience 25:817.
43. Hadcock, J. R., D. L. Williams, and C. C. Malbon. 1989. Physiological regulation at the level of mRNA: analysis of steady-state levels of specific mRNAs by DNA-excess solution hybridization. Am. J. Physiol. 256:C457.
44. Fong, T. M., S. A. Anderson, H. Yu, R. C. Huang, and C. D. Strader. 1991. Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor. Mol. Pharmacol. 41:24.
45. Shanahan, F. 1994. The intestinal immune system. In Physiology of the Gastrointestinal Tract, 3rd Ed. L. R. Johnson, ed. Raven Press, New York, p. 643.
46. Elson, C. O., and K. W. Beagley. 1994. Cytokines and immune mediators. In Physiology of the Gastrointestinal Tract, 3rd Ed. L. R. Johnson, ed. Raven Press, New York, p. 243.
47. Sedqi, M., S. Roy, D. Mohanraj, S. Ramakrishnan, and H. H. Loh. 1996. Activation of rat thymocytes selectively up-regulates the expression of somatostatin receptor subtype-1. Biochem. Mol. Biol. Int. 38:103.
48. Rameshwar, P., and P. Gascon. 1995. Substance P (SP) mediates production of stem cell factor and interleukin-1 in bone marrow stroma: potential autoregulatory role for these cytokines in SP receptor expression and induction. Blood 86:482.
49. Ho, W.-Z., J.-P. Lai, X.-H. Zhu, M. Uvagdova, and S. D. Douglas. 1997. Human monocytes and macrophages express substance P and neurokinin-1 receptor. J. Immunol. 159:5654.