Inhibitory function of whey acidic protein in the cell-cycle progression of mouse mammary epithelial cells (EpH4 / K6 cells)

Journal of Reproduction and Development

Volumn 50, Issue 1, 2004, Pages 87-96

  Ikeda, Kayoko ^a   Nukumi, Naoko ^a   Iwamori, Tokuko ^a   Osawa, Megumi ^a   Naito, Kunihiko ^a   Tojo, Hideaki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Cell cycle; Cell proliferation; Cyclin Ds; EpH4 cells; Mammary epithelial cells; Whey acidic protein (WAP)

Indexed keywords

BROXURIDINE; CYCLIN D1; CYCLIN D2; CYCLIN D3; MILK PROTEIN; UNCLASSIFIED DRUG; WHEY ACIDIC PROTEIN; CYCLIN D; CYCLINE; SCLEROPROTEIN; WHEY ACIDIC PROTEINS;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; BREAST EPITHELIUM; CELL CULTURE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE MEDIUM; EXTRACELLULAR MATRIX; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PARACRINE SIGNALING; PLASMID; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; CELL DIVISION; CELL LINE; CYTOLOGY; EPITHELIUM CELL; GENE EXPRESSION; GENETICS; PHYSIOLOGY; UDDER;

ANIMALIA;

ANIMALS; AUTOCRINE COMMUNICATION; CELL DIVISION; CELL LINE; CYCLINS; EPITHELIAL CELLS; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION; MAMMARY GLANDS, ANIMAL; MICE; MILK PROTEINS; PARACRINE COMMUNICATION;

EID: 4644342508     PISSN: 09168818     EISSN: None     Source Type: Journal    
DOI: 10.1262/jrd.50.87     Document Type: Article

References (47)

1. Hennighausen LG, Sippel AE. Characterization and cloning of the mRNAs specific for the lactating mouse mammary gland. Eur J Biochem 1982; 125: 131-141.
2. Campbell SM, Rosen JM, Hennighausen LG, Strech JU, Sippel AE. Comparison of the whey acidic protein genes of the rat and mouse. Nucleic Acids Res 1984; 12: 8685-8697.
3. Beg OU, Bahr-Lindstrom HV, Zaidi ZH, Jornvall HA. A small camel-milk protein rich in cysteine/half-cysteine. Bioscience Rep 1984; 4: 1065.
4. Devinoy E, Hubert C, Jolivet G, Thepot D, Clergue N, Desaleux M, Servely JL, Houdebine LM. Recent data on the structure of rabbit milk protein genes and on the mechanism of the hormonal control of their expression. Reprod Nutr Dev 1988; 28: 1145-1164.
5. Simpson KJ, Bird P, Shaw D, Nicholas K. Molecular characterization and hormone-dependent expression of the porcine whey acidic protein gene. J Mol Endcrinol 1988; 20: 27-35.
6. Rival S, Attal J, Delville-Giraud C, Yerle M, Laffont P, Rogel-Gaillard C, Houdebine LM. Cloning, transcription and chromosomal localization of the porcine whey acidic protein gene and its expression in HC11 cell line. Gene 2001; 267: 37-47.
7. Simpson KJ, Ranganathan S, Fisher JA, Janssens PA, Shaw DC, Nicholas KR. The gene for a novel member of the whey acidic protein family encodes three four-disulfide core domains and is asynchronously expressed during lactation. J Biol Chem 2000; 275: 23074-23081.
8. Nicholas KR, Fisher JA, Muths E, Trott J, Janssens PA, Reich C, Shaw DC. Secretion of whey acidic protein and cystatin is down regulated at mid-lactation in the red kangaroo (Macropus rufus). Comp Biochem Physiol A Mol Integr Physiol 2001; 129: 851-858.
9. Demmer J, Stasiuk SJ, Grigor MR, Simpson KJ, Nicholas KR. Differential expression of the whey acidic protein gene during lactation in the brushtail possum (Trichosurus vulpecula). Biochim Biophys Acta 2001; 1522: 187-194.
10. Pittius CW, Sankaran L, Topper YJ, Hennighausen L. Comparison of the regulation of the whey acidic protein gene with that of a hybrid gene containing the whey acidic protein gene promoter in transgenic mice. Mol Endocrinol 1988; 2: 1027-1032.
11. Dandekar AM, Robinson EA, Appella E, Qasba PK. Complete sequence analysis of cDNA clones encoding rat whey phosphoprotein: Homology to a proteinase inhibitor. Proc Natl Acad Sci USA 1982; 79: 3987-3991.
12. Hennighausen LG, Sippel AE. Mouse whey acidic protein is a novel member of the family of four-disulfide core protein. Nucleic Acids Res 1982; 10: 2677-2684.
13. Heinzel R, Appelhans H, Gassen G, Seemuller U, Machleidt W, Fritz H, Steffens G. Molecular cloning and expression of cDNA for human anti-leukoprotease from cervix uterus. Eur J Biochem 1986; 160: 61-67.
14. Wiedow O, Schroder JM, Gregory H, Young JA, Christophers E. Elafin: an elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence. J Biol Chem 1990; 265: 14791-14795.
15. Kirchhoff C, Habben I, Ivell R, Krull N. A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular protease inhibitors. Biol Reprod 1991; 45: 350-357.
16. Garczynski MA, Goetz FW. Molecular characterization of a ribonucleic acid transcript that is highly up-regulated at the time of ovulation in the brook trout (Salvelinus fontinalis) ovary. Biol Reprod 1997; 57: 856-864.
17. Larsen M, Ressler SJ, Lu B, Gerdes MJ, Mcbride L, Dang TD, Rowley DR. Molecular cloning and expression of ps20 growth inhibitor A novel WAP-type "four-disulfide core" domain protein expressed in smooth muscle. J Biol Chem 1998; 273: 4574-4584.
18. Ranganathan S, Simpson KJ, Shaw DC, Nicholas KR. The whey acidic protein family: A new signature motif and three-dimensional structure by comparative modeling. J Mol Graph Model 2000; 17: 106-113.
19. Nicholas K, Simpson K, Wilson M, Trott J, Shaw D. The tammar wallaby: a model to study putative autocrine-induced changes in milk composition. J Mammary Gland Biol Neoplasia 1997; 2: 299-310.
20. Burdon T, Wall RJ, Shamay A, Smith GH, Hennighausen L. Over-expression of an endogenous milk protein gene in transgenic mice is associated with impaired mammary alveolar development and a milchlos phenotype. Median Dev 1992; 36: 67-74.
21. Shamay A, Pursel VG, Wilkinson E, Wall RJ, Hennighausen L. Expression of the whey acidic protein in transgenic pigs impairs mammary development. Transgenic Res 1992; 1: 124-132.
22. Guntzburg WH, Salmons B, Zimmermann B, Muller M, Erfle V, Brem G. A mammary-specific promoter directs expression of growth hormone not only to the mammary gland, but also to Bergman glia cells in transgenic mice. Mol Endocrinol 1991; 5: 123-132.
23. Tojo H, Tanaka S, Matsuzaka A, Takahashi M, Tachi C. Production and characterization of transgenic mice expression a hGH fusion gene driven by the promoter of mouse whey acidic protein (mWAP) putatively specific to mammary gland. J Reprod Dev 1993; 39: 145-155.
24. Wen J, Kawamata Y, Tojo H, Tanaka S, Tachi C. Expression of whey acidic protein (WAP) genes in tissues other than the mammary gland in normal and transgenic mice expressing mWAP/hGH fusion gene. Mol Reprod Dev 1995; 41: 399-406.
25. Niemann C, Brinkmann V, Spitzer E, Hartmann G, Sachs M, Naundorf H, Birchmeier W. Reconstitution of mammary gland development in vitro: requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis. J Cell Biol 1998; 143: 533-545.
26. Kuhl U, Ocalan M, Timol R, von der Mark K. Role of laminin and fibronectin in selecting myogenic versus fibrogenic cells from skeletal muscle cells in vitro. Dev Biol 1986; 117: 628-635.
27. Li G, Fridman R, Kim HR. Tissue inhibitor of metalloproteinase-1 inhibits apoptosis of human breast epithelial cells. Cancer Res 1999; 59: 6267-6275.
28. Hennighausen L, McKnight R, Burdon T, Baik M, Wall RJ, Smith GH. Whey acidic protein extrinsically expressed from the mouse mammary tumor virus long terminal repeat results in hyperplasia of the coagulation gland epithelium and impaired mammary development. Cell Growth Differ 1994; 5: 607-613.
29. Ballard FJ, Grbovac S, Nicholas KR, Owens PC, Read LC. Differential changes in the milk concentrations of epidermal growth factor and insulin-like growth factor-I during lactation in the tammar wallaby, Macropus eugenii. Gen Comp Endocrinol 1995; 98: 262-268.
30. Kordon EC, McKnight RA, Jhappan C, Hennighausen L, Merlino G, Smith GH. Ectopic TGF β1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population. Dev Biol 1995; 168: 47-61.
31. Robinson GW, Mcknight RA, Smith GH, Hennighausen L. Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation. Development 1995; 121: 2079-2090.
32. Ikeda K, Kato M, Yamanouchi K, Naito K, Tojo H. Novel development of mammary glands in the nursing transgenic mouse ubiquitously expressing WAP gene. Exp Anim 2002; 51: 395-399.
33. Sherr GJ, Roberts JM. CDK inhibitors: Positive and negative regulators of G1-phase progression. Genens Dev 1999; 13: 1501-1512.
34. Inaba T, Matsushime H, Valentine M, Roussel MF, Sherr CJ, Look AT. Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. Genomics 1992; 13: 565-574.
35. Xiong Y, Menninger J, Beach D, Ward DC. Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. Genomics 1992; 13: 575-584.
36. Matushime H, Ewen ME, Strom DK, Kato JY, Hanks SK, Roussel MF, Sherr CJ. Identification and properties of an atypical catalytic subunit (p34PSK-j3/cdk4) for mammalian D type G1 cyclins. Cell 1992; 71: 323-334.
37. Matushime H, Quelle DE, Shurtleff SA, Shibuya M, Sherr CJ, Kato JY. D-type cyclin-dependent kinase activity in mammalian cells. Mol Cell Biol 1994; 14: 2066-2076.
38. Bates S, Bonetta L, MacAllan D, Parry D, Holder A, Dickson C, Peters G. CDK6(PLSTIRE) and CDK4(PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1. Oncogene 1994; 9: 71-79.
39. Meyerson M, Harlow E. Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol Cell Biol 1994; 14: 2077-2086.
40. Adams PD. Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks. Biochim Biophys Acta 2001; 1471: M123-133.
41. Dickson C, Fantl V, Gillett C, Brookes S, Bartek J, Smith R, Fisher C, Barnes D, Peters G. Amplification of chromosome band 11q13 and a role for cyclin D1 in human breast cancer. Cancer Lett 1995; 90: 43-50.
42. Kronenberg HM, Auneld A. A novel cyclin encoded by a bell-linked candidate oncogene. Nature 1991; 350: 512-515.
43. Bartkova J, Lukas J, Muller H, Lutzhoft D, Strauss M, Bartek J. Cyclin D1 protein expression and function in human breast cancer. Int J Cancer 1994; 57: 353-361.
44. Wang TC, Cardiff RD, Zukerberg L, Lees E, Arnold A, Schmidt EV. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Nature 1994; 369: 669-671.
45. Burdon T, Sankaran L, Wall RJ, Spencer M, Hennighausen L. Expression of a whey acidic protein transgene during mammary development. J Biol Chem 1991; 266: 6909-6914.
46. Matsumoto T, Hayashi K, Nishida E. Cyclin-dependent kinase 2(Cdk2) is required for centrosome duplication in mammalian cells. Curr Biol 1999; 9: 429-432.
47. Kramps JA, Franken C, Dijkman JH. Quantity of anti-leukoprotease relative to alpha 1-proteinase inhibitor in peripheral airspaces of the human lung. Clin Sci (Lond) 1988; 75: 351-353.