Neoadjuvant chemoradiotherapy for adenocarcinoma of the pancreas: Analysis of histopathology and outcome

International Journal of Gastrointestinal Cancer

Volumn 34, Issue 2-3, 2004, Pages 121-127

  Sasson, Aaron R ^a   Wetherington, R Wesley ^a   Hoffman, John P ^a   Ross, Eric A ^a   Cooper, Harry ^a   Meropol, Neal J ^a   Freedman, Gary ^a   Pingpank, James F ^a   Eisenberg, Burton L ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

Adjuvant treatment; Chemotherapy; Histopathology; Pancreatic cancer; Radiotherapy

Indexed keywords

ANTINEOPLASTIC AGENT; FLUOROURACIL; GEMCITABINE; MITOMYCIN C;

ADULT; AGED; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SIZE; CANCER SURVIVAL; FEMALE; FIBROSIS; HISTOPATHOLOGY; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PANCREAS RESECTION; PANCREATICODUODENECTOMY; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY; REVIEW; TREATMENT OUTCOME;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DEOXYCYTIDINE; FEMALE; FIBROSIS; FLUOROURACIL; HUMANS; MALE; MIDDLE AGED; MITOMYCIN; NEOADJUVANT THERAPY; PANCREATECTOMY; PANCREATIC NEOPLASMS; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS;

EID: 4644328367     PISSN: 01694197     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (18)

1. Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer. Gastrointestinal Tumor Study Group. Cancer 1987;59(12):2006-2010.
2. Whittington R, Bryer MP, Haller DG, Solin LJ, Rosato EF. Adjuvant therapy of resected adenocarcinoma of the pancreas. Int J Radiat Oncol Biol Phys 1991 Oct;21(5): 1137-1143.
3. Yeo CJ, Abrams RA, Grochow LB, et al. Pancreaticoduodenectomy for pancreatic adenocarcinoma: postoperative adjuvant chemoradiation improves survival. A prospective, single-institution experience. Ann Surg 1997;225(5): 621-633.
4. Klinkenbijl JH, Jeekel J, Sahmoud T, et al. Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: phase III trial of the EORTC gastrointestinal tract cancer cooperative group. Ann Surg. 1999;230(6):776-782.
5. Spitz FR, Abbruzzese JL, Lee JE, et al. Preoperative and postoperative chemoradiation strategies in patients treated with pancreaticoduodenectomy for adenocarcinoma of the pancreas. J Clin Oncol 1997;15(3):928-937.
6. Yeo CJ, Cameron JL, Sohn TA, et al. Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: pathology, complications, and outcomes. Ann Surg 1997;226:248-257.
7. Conlon KC, Klimstra DS, Brennan MF. Long-term survival after curative resection for pancreatic ductal adenocarcinoma. Clinicopathologic analysis of 5-year survivors. Ann Surg 1996;223:273-279.
8. Benassai G, Mastrorilli M, Quarto G, Cappiello A, Giani U, Forestieri P, Mazzeo F. Factors influencing survival after resection for ductal adenocarcinoma of the head of the pancreas. J Surg Oncol 2000;73:212-218.
9. Millikan KW, Deziel DJ, Silverstein JC, Kanjo TM, Christein JD, Doolas A, Prinz RA. Prognostic factors associated with resectable adenocarcinoma of the head of the pancreas. Am Surg 1999;65:618-623.
10. Willett CG, Lewandrowski K, Warshaw AL, Efird J, Compton CC. Resection margins in carcinoma of the head of the pancreas. Implications for radiation therapy. Ann Surg 1993;217:144-148.
11. Geer RJ, Brennan MF. Prognostic indicators for survival after resection of pancreatic adenocarcinoma. Am J Surg 1993;165(1):68-72.
12. Pingpank JF, Hoffman JP, Ross E, et al. Effect of preoperative chemoradiotherapy on surgical margin status of resected adenocarcinoma of the head of the pancreas. J Gastrointest Surg 2001;5:121-130.
13. Ishikawa O, Ohhigashi H, Teshima T, et al. Clinical and histopathological appraisal of preoperative irradiation for adenocarcinoma of the pancreatoduodenal region. J Surg Oncol 1989;40:143-151.
14. Pendurthi, TK, Cooper HS, Young NA, et al. Histopathologic effects of preoperative chemoradiotherapy on pancreatic carcinoma (abstract). American Gastroenterology Association 1996;1082:271.
15. Hoffman JP, Weese JL, Solin LJ, et al. A single institutional experience with preoperative chemoradiotherapy for stage I-III pancreatic adenocarcinoma. Am Surg 1993; 59:772-780.
16. Hoffman JP, Lipsitz S, Pisansky T, Weese JL, Solin L, Benson AB 3rd. Phase II trial of preoperative radiation therapy and chemotherapy for patients with localized, resectable adenocarcinoma of the pancreas: an Eastern Cooperative Oncology Group Study. J Clin Oncol 1998;16:317-323.
17. Hoffman JP, McGinn CJ, Szarka C, Morphis J, Cooper HS, Wilkes J, Nicol S. A phase 1 study of preoperative gemcitabine (GEM) with radiation therapy (RT) followed by posteroperative GEM for patients with localized, resectable pancreatic adenocarcinoma (PAC). Proc Am Soc Clin Oncol 1998;17:A 1090 (abstract).
18. Breslin TM, Hess KR. Harbison DB. et al. Neoadjuvant chemoradiotherapy for adenocarcinoma of the pancreas: treatment variables and survival duration. Ann Surg Oncol 2001 Mar;8(2):123-132.