The BOLD response: A new look at an old riddle

NeuroReport

Volumn 15, Issue 13, 2004, Pages 1997-2000

  Marcar, Valentine L ^a   Loenneker, Thomas ^a,b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

Author keywords

Action potential; Cerebral blood flow; Neuronal population; Oxygen consumption

Indexed keywords

ACTION POTENTIAL; BRAIN BLOOD FLOW; BRAIN METABOLISM; BRAIN NERVE CELL; BRAIN OXYGEN CONSUMPTION; ELECTROENCEPHALOGRAM; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; REVIEW; SIGNAL DETECTION; STIMULUS RESPONSE; THEORETICAL MODEL;

ANIMALS; BRAIN; HUMANS; MAGNETIC RESONANCE IMAGING; MODELS, NEUROLOGICAL; NEURONS; OXYGEN; TIME FACTORS;

EID: 4644300758     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001756-200409150-00001     Document Type: Review

References (16)

1. Keri S and Gulyas B. Four facets of a single brain: behaviour, cerebral blood flow/metabolism, neuronal activity and neurotransmitter dynamics. Neuroreport 2003; 14:1097-1106.
2. Ogawa S, Menon RS, Tank DW, Kim SG, Merkle H, Ellermann JM et al. Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model. Biophys J 1993; 64:803-812.
3. Shmuel A, Yacoub E, Pfeuffer J, Van de Moortele PF, Adriany G, Hu X and Ugurbil K. Sustained negative BOLD, blood flow and oxygen consumption response and its coupling to the positive response in the human brain. Neuron 2002; 36:1195-1210.
4. Malonek D, Dirnagl U, Lindauer U, Yamada K, Kanno I and Grinvald A. Vascular imprints of neuronal activity: relationships between the dynamics of cortical blood flow, oxygenation, and volume changes following sensory stimulation. Proc Natl Acad Sci USA 1997; 94: 14826-14831.
5. Logothetis NK, Pauls J, Augath M, Trinath T and Oeltermann A. Neurophysiological investigation of the basis of the fMRI signal. Nature 2001; 412:150-157.
6. Kleinschmidt A, Lee BB, Requardt M and Frahm J. Functional mapping of color processing by magnetic resonance imaging of responses to selective P- and M-pathway stimulation. Exp Brain Res 1996; 110:279-288.
7. 2 from CBF and BOLD changes: significant increase of oxygen consumption rate during visual stimulation. Magn Reson Med 1999; 41:1152-1161.
8. Fox PTR. Stimulus Rate Determines Regional Brain Blood Flow in Striate Cortex. Ann Neurol 1985; 17:303-305.
9. Shulman RG, Hyder F and Rothman DL. Cerebral energetics and the glycogen shunt: neurochemical basis of functional imaging. Proc Natl Acad Sci USA 2001; 98:6417-6422.
10. Cholet N, Seylaz J, Lacombe P and Bonvento G. Local uncoupling of the cerebrovascular and metabolic responses to somatosensory stimulation after neuronal nitric oxide synthase inhibition. J Cerebr Blood Flow Metab 1997; 17:1191-1201.
11. Wobst P, Wenzel R, Kohl M, Obrig H and Villringer A. Linear aspects of changes in deoxygenated hemoglobin concentration and cytochrome oxidase oxidation during brain activation. Neuroimage 2001; 13:520-530.
12. Marcar VLS, Loenneker A, Girard T and Martin E. When more means less: a paradox BOLD response in human visual cortex. Magn Reson Imag 2004; 22:441-450.
13. Thompson JK, Peterson MR and Freeman RD. Single-neuron activity and tissue oxygenation in the cerebral cortex. Science 2003; 299:1070-1072.
14. Bookheimer SY, Strojwas MH, Cohen MS, Saunders AM, Pericak-Vance MA, Mazziotta JC et al. Patterns of brain activation in people at risk for Alzheimer's disease. N Engl J Med 2000; 343:450-456.
15. Huk AC and Heeger DJ. Task-related modulation of visual cortex. J Neurophysiol 2000; 83:3525-3536.
16. Albright TD, Desimone R and Gross CG. Columnar organization of directionally selective cells in visual area MT of the macaque. J Neurophysiol 1984; 51:16-31.