The influence of age on the treadmill exercise-induced c-Fos expression in the hippocampus of rats

Neuroscience Research Communications

Volumn 35, Issue 1, 2004, Pages 41-50

  Kim, Sang Ho ^a   Kim, Hong ^a,b   Kim, Sung Soo ^a   Shin, Mal Soon ^b   Chang, Hyun Kyung ^b   Lee, Taeck Hyun ^b   Jang, Mi Hyeon ^b   Shin, Min Chul ^b   Lee, Hee Hyuk ^b   Kim, Young Pyo ^c   Kim, Chang Ju ^b  

^a Korea University   (South Korea)

^b Kyung Hee University Hospital   (South Korea)

^c Hannam University   (South Korea)

Author keywords

Age; c Fos; Hippocampus; Immunohistochemistry; Treadmill exercise

Indexed keywords

AGE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENTATE GYRUS; GENE EXPRESSION; HIPPOCAMPUS; MALE; NONHUMAN; ONCOGENE C FOS; RAT; RUNNING; TREADMILL EXERCISE;

EID: 4644280511     PISSN: 08936609     EISSN: None     Source Type: Journal    
DOI: 10.1002/nrc.20018     Document Type: Article

References (38)

1. Kramer AF, Hahn S, Cohen NJ, Banich MT, McAuley E, Harrison CR, Chason J, Vakil E, Bardell L, Boileau RA, Colcombe A. Ageing, fitness and neurocognitive function. Nature 1999;400:418-419.
2. Cotman CW, Berchtold NC. Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci 2002;25:295-301.
3. Mattson MP. Neuroprotective signaling and the aging brain: take away my food and let me run. Brain Res 2000;886:47-53.
4. Laurin D, Verreault R, Lindsay J, MacPherson K, Rockwood K. Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol 2001;58:498-504.
5. Friedland RP, Fritsch T, Smyth KA, Koss E, Lerner AJ, Chen CH, Petot GJ, Debanne SM. Patients with Alzheimer's disease have reduced activities in midlife compared with healthy control-group members. Proc Natl Acad Sci USA 2001;98:3440-3445.
6. Neeper SA, Gómez-Pinilla F, Choi J, Cotman CW. Exercise and brain neurotrophins. Nature 1995;373:109.
7. Iwamoto GA, Wappel SM, Fox GM, Buetow KA, Waldrop TG. Identification of diencephalic and brainstem cardiorespiratory areas activated during exercise. Brain Res 1996;726:109-122.
8. Gómez-Pinilla F, So V, Kesslak JP. Spatial learning and physical activity contributes to the induction of fibroblast growth factor: neural substrates for increased cognition associated with exercise. Neuroscience 1998;85:53-61.
9. van Praag H, Christie BR, Sejnowski TJ, Gage FH. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci USA 1999;96:13427-13431.
10. Tong L, Shen H, Perreau VM, Balazs R, Cotman CW. Effects of exercise on gene-expression profile in the rat hippocampus. Neurobiol Dis 2001;8:1046-1056.
11. Hiroi N, Brown JR, Haile CN, Ye H, Greenberg ME, Nestler EJ. FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects. Proc Natl Acad Sci USA 1997;94:10397-10342.
12. Hoffmann GE, Smith MS, Verbalis JG. c-fos and related immediate early gene products as markers of activity in neuroendocrine systems. Front Neuroendocrinol 1993;14:173-213.
13. Kovács KJ. c-Fos as a transcription factor: a stressful (re)view from a functional map. Neurochem Int 1998;33:287-297.
14. Bellchambers CE, Chieng B, Keay KA, Christie MJ. Swim-stress but not opioid withdrawal increases expression of c-fos immunoreactivity in rat periaqueductal gray neurons which project to the rostral ventromedial medulla. Neuroscience 1998;83:517-524.
15. Lee TH, Jang MH, Shin MC, Lim BV, Kim YP, Kim H, Choi HH, Lee KS, Kim EH, Kim CJ. Dependence of rat hippocampal c-Fos expression on intensity and duration of exercise. Life Sci 2003;72:1421-1436.
16. Guzowski JF. Insights into immediate-early gene function in hippocampal memory consolidation using antisense oligonucleotide and fluorescent imaging approaches. Hippocampus 2002;12:86-104.
17. Tischmeyer W, Grimm R. Activation of immediate early genes and memory formation. Cell Mol Life Sci 1999;55:564-574.
18. Vann SD, Brown MW, Erichsen JT, Aggleton JP. Fos imaging reveals differential patterns of hippocampal and parahippocampal subfield activation in rats in response to different spatial memory tests. J Neurosci 2000;20:2711-2718.
19. He J, Yamada K, Nabeshima T. A role of Fos expression in the CA3 region of the hippocampus in spatial memory formation in rats. Neuropsychopharmacol 2002;26:259-268.
20. Worley PF, Bhat R, Baraban JM, Erickson CA, McNaughton BL, Barnes CA. Thresholds for synaptic activation of transcription factors in the hippocampus: Correlation with long term enhancement. J Neurosci 1933;13:4776-4786.
21. Desjardins S, Mayo W, ValléE M, Hancock D, Le Moal M, Simon H, Abrous DN. Effect of Aging on the Basal Expression of c-Fos, c-Jun, and Egr-1 Proteins in the Hippocampus. Neurobiol Aging 1997;18:37-44.
22. Sutin EL, Dement WC, Heller HG, Kilduff TS. Light-induced gene expression in the suprachiasmatic nucleus of young and aging rats. Neurobiol Aging 1993;14:441-446.
23. Kitraki E, Bozas E, Philippidis H, Stylianopoulou F. Aging-related changes in GF-II and c-fos gene expression in the rat brain. Int J Dev Neurosci 1993;11:1-9.
24. Cai A, Lehman MN, Lloyd JM, Wise PM. Transplantation of fetal suprachiasmatic nuclei into middle-aged rats restores diurnal Fos expression in host. Am J Physiol 1997;272:R422-R428.
25. Sutin EL, Dement, WC, Heller C, Kilduff TS. Light-induced gene expression in the suprachiasmatic nucleus of young and aging rats. Neurobiol Aging 1993;14:441-446.
26. Schmoll H, Badana I, Fischerb B, Wagner AP. Dynamics of gene expression for immediate early and late genes after seizure activity in aged rats. Arch Gerontol Geriatr 2001;32:199-218.
27. Sandin J, Nylander I, Georgieva J, Schott PA, Ogren SO, Terenius L. Hippocampal dynorphin B injections impair spatial learning in rats: a kappa-opioid receptor-mediated effect. Neuroscience 1998;85:375-382.
28. Rosenzweig ES, Barnes CA. Impact of aging on hippocampal function: plasticity, network dynamics, and cognition. Prog Neurobiol 2003;69:143-179.
29. Dayas CV, Buller KM, Crane JW, Xu Y, Day TA. Stressor categorization: acute physical and psychological stressors elicit distinctive recruitment patterns in the amygdala and in medullary noradrenergic cell groups. Eur J Neurosci 2001;14:1143-1152.
30. Oladehin A, Waters RS. Location and distribution of Fos protein expression in rat hippocampus following acute moderate aerobic exercise. Exp Brain Res 2001;137:26-35.
31. Bialy M, Kaczmarek L. c-Fos expression as a tool to search for the neurobiological base of the sexual behaviour of males. Acta Neurobiol Exp 1996;56:567-577.
32. Shizuki K, Ogawa K, Matsunobu T, Kanzaki J, Ogita K. Expression of c-Fos after noise-induced temporary threshold shift in the guinea pig cochlea. Neurosci Lett 2002;320:73-76.
33. Hoffman GE, Lyo D. Anatomical markers of activity in neuroendocrine systems: are we all 'fos-ed out'?. J Neuroendocrinol 2002;14:259-268.
34. Jasmin L, Gogas KR, Ahlgren SC, Levine JD, Basbaum AI. Walking evokes a distinctive pattern of Fos-like immunoreactivity in the caudal brainstem and spinal cord of the rat. Neuroscience 1994;58:275-286.
35. Carro E, Trejo JL, Busiguina S, Torres-Aleman I. Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy. J Neurosci 2001;21:5678-5684.
36. Skalicky M, Bubna-Littitz H, Viidik A. Influence of physical exercise on aging rats: I. Life-long exercise preserves patterns of spontaneous activity. Mech Ageing Dev 1996;87:127-139.
37. Fordyce DE, Wehner JM. Physical activity enhances spatial learning performance with an associated alteration in hippocampal protein kinase C activity in C57BL/6 and DBA/2 mice. Brain Res 1993;619:111-119.
38. Anderson BJ, Rapp DN, Baek DH, McCloskey DP, Coburn-Litvak PS, Robinson JK. Exercise influences spatial learning in the radial arm maze. Physiol Behav 2000;70:425-429.