CARB-9, a carbenicillinase encoded in the VCR region of Vibno cholerae non-O1, non-O139 belongs to a family of cassette-encoded β-lactamases

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 10, 2004, Pages 4042-4046

  Petroni, Alejandro ^a   Melano, Roberto G ^a,b   Saka, Héctor A ^a   Garutti, Alicia ^a   Mange, Laura ^a   Pasterán, Fernando ^a   Rapoport, Melina ^a   Miranda, Mariana ^a   Faccone, Diego ^a   Rossi, Alicia ^a   Hoffman, Paul S ^b   Galas, Marcelo F ^a  

^a INSTITUTO NACIONAL DE ENFERMEDADES INFECCIOSAS   (Argentina)

^b DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE; CARBENICILLINASE 9; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; DNA FLANKING REGION; GENE CASSETTE; GENE LOCATION; INTEGRON; MINIMUM INHIBITORY CONCENTRATION; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; SEQUENCE ANALYSIS; VIBRIO CHOLERAE;

AMINO ACID SEQUENCE; ARGENTINA; BETA-LACTAMASES; MOLECULAR SEQUENCE DATA; PENICILLINASE; REPETITIVE SEQUENCES, AMINO ACID; VIBRIO CHOLERAE;

EID: 4644279303     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.10.4042-4046.2004     Document Type: Article

References (29)

1. Ambler, R. P., A. F. W. Coulson, J. M. Frere, J. M. Ghuysen, B. Joris, M. Forsman, R. C. Levesque, G. Tirabi, and S. G. Waley. 1991. A standard numbering scheme for the class A β-lactamases. Biochem. J. 276:269-272.
2. Briggs, C. E., and P. M. Fratamico. 1999. Molecular characterization of an antibiotic resistance gene cluster of Salmonella typhimurium DT104. Antimicrob. Agents Chemother. 43:846-849.
3. Chakraborty, S., P. Garg, T. Ramamurthy, M. Thungapathra, J. K. Gautam, C. Kumar, S. Maiti, S. Yamasaki, T. Shimada, Y. Takeda, A. Ghosh, and G. B. Nair. 2001. Comparison of antibiogram, virulence genes, ribotypes and DNA fingerprints of Vibrio cholerae of matching serogroups isolated from hospitalised diarrhoea cases and from the environment during 1997-1998 in Calcutta, India. J. Med. Microbiol. 50:879-888.
4. Choury, D., G. Aubert, M.-F. Szajnert, K. Azibi, M. Delpech, and G. Paul. 1999. Characterization and nucleotide sequence of CARB-6, a new carbenicillin-hydrolyzing β-lactamase from Vibrio cholerae. Antimicrob. Agents Chemother. 43:297-301.
5. RTG-2 (CARB-5) gene and phylogeny of a new group of carbenicillinases. Antimicrob. Agents Chemother. 44:1070-1074.
6. Clark, C. A., L. Purins, P. Kaewrakon, T. Focareta, and P. A. Manning. 2000. The Vibrio cholerae O1 chromosomal integron. Microbiology 146:2605-2612.
7. Dalsgaard, A., A. Forslund, D. Bodhidatta, C. Serichantalergs, L. Pitarangsi, T. Pang, T. Shimada, and P. Echevema. 1999. A. high proportion of V. cholerae isolated from children with diarrhoea in Bangkok, Thailand are multiple antibiotic resistant and belong to heterogeneous non-O1, non-O139 O-serotypes. Epidemiol. Infect. 122:217-226.
8. Dalsgaard, A., A. Forslund, O. Serichantalergs, and D. Sandvang. 2000. Distribution and content of class 1 integrons in different Vibrio cholerae O-serotype strains isolated in Thailand. Antimicrob. Agents Chemother. 44:1315-1321.
9. Heidelberg, J., J. Eisen, W. Nelson, R. Clayton, M. Gwinn, R. Dodson, D. Haft, E. Hickey, J. Peterson, L. Umayam, S. Gill, K. Nelson, T. Read, H. Tettelin, D. Richardson, M. Ermolaeva, J. Vamathevan, S. Bass, H. Qin, I. Dragoi, P. Sellers, L. McDonald, T. Utterback, R. Fleishmann, W. Nierman, O. White, S. Salzberg, H. Smith, R. Colwell, J. Mekalanos, J. Venter, and C. Fraser. 2000. DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae. Nature 406:477-483.
10. Isaac-Márquez, A. P., C. M. Lezama-Davila, C. Eslava-Campos, A. Navarro-Ocana, and A. Cravioto-Quintana. 1998. Serotypes of Vibrio cholerae non-O1 isolated from water supplies for human consumption in Campeche, México and their antibiotic susceptibility patterns. Mem. Inst. Oswaldo Cruz 93:17-22.
11. Ito, Y., and T. Hirano. 1997. Carbenicillin-hydrolysing penicillinase mediated by a plasmid of Proteus mirabilis and its relationship to the PSE-type enzymes of Pseudomonas aeruginosa. J. Appl. Microbiol. 83:175-180.
12. Joris, B., J. Ghuysen, G. Dive, A. Renard, O. Dideberg, P. Charlier, J. Frère, J. Kelly, J. Boyington, P. Moews, and J. Knox. 1988. The active-site-serine penicillin-recognizing enzymes as members of the Streptomyces R61 DD-peptidase family. Biochem. J. 250:313-324.
13. Lachapelle, J., J. Dufresne, and R. C. Levesque. 1991. Characterization of the blaCARB-3 gene encoding the carbenicillinase-3 beta-lactamase of Pseudomonas aeruginosa. Gene 102:7-12.
14. Levesque, R. C., and G. A. Jacoby. 1988. Molecular structure and interrelationships of multiresistance β-lactamase transposons. Plasmid 19:21-29.
15. Lim, D., F. Sanschagrin, L. Passmore, L. De Castro, R. C. Levesque, and N. C. Strynadka. 2001. Insights into the molecular basis for the carbenicillinase activity of PSE-4 beta-lactamase from crystallographic and kinetic studies. Biochemistry 40:395-402.
16. Mammeri, H., L. Poirel, N. Mangeney, and P. Nordmann. 2003. Chromosomal integration of a cephalosporinase gene from Acinetobacter baumannii into Oligella urethralis as a source of acquired resistance to β-lactams. Antimicrob. Agents Chemother. 47:1536-1542.
17. Mazel, D., B. Dychinco, V. Webb, and J. Davies. 1998. A distinctive class of integron in the Vibrio cholerae genome. Science 280:605-608.
18. Medeiros, A. A., R. W. Hedges, and G. A. Jacoby. 1982. Spread of a "Pseudomonas-specific" β-lactamase to plasmids of enterobacteria. J. Bacteriol. 149: 700-707.
19. Melano, R., A. Petroni, A. Garutti, H. A. Saka, L. Mange, F. Pasterán, M. Rapoport, A. Rossi, and M. Galas. 2002. New carbenicillin-hydrolyzing beta-lactamase (CARB-7) from Vibrio cholerae non-O1, non-O139 strains encoded by the VCR region of the V. cholerae genome. Antimicrob. Agents Chemother. 46:2162-2168.
20. Naas, T., Y. Mikami, T. Imai, L. Poirel, and P. Nordmann. 2001. Characterization of In53, a class 1 plasmid- and composite transposon-located integron of Escherichia coli which carries an unusual array of gene cassettes. J. Bacteriol. 183:235-249.
21. Pai, H., J.-H. Byeon, S. Yu, B. K. Lee, and S. Kim. 2003. Salmonella enterica serovar Typhi strains isolated in Korea containing a multidrug resistance class 1 integron. Antimicrob. Agents Chemother. 47:2006-2008.
22. Partridge, S. R., H. J. Brown, and R. M. Hall. 2002. Characterization and movement of the class 1 integron known as Tn2527 and Tn1405. Antimicrob. Agents Chemother. 46:1288-1294.
23. Partridge, S. R., G. D. Recchia, H. W. Stokes, and R. M. Hall. 2001. Family of class 1 integrons related to In4 from Tn1696. Antimicrob. Agents Chemother. 45:3014-3020.
24. Rowe-Magnus, D. A., A.-M. Guerout, L. Biskri, P. Bouige, and D. Mazel. 2003. Comparative analysis of superintegrons: engineering extensive genetic diversity in the Vibrionaceae. Genome Res. 13:428-442.
25. Rowe-Magnus, D. A., A.-M. Guerout, and D. Mazel. 2002. Bacterial resistance evolution by recruitment of super-integron gene cassettes. Mol. Microbiol. 43:1657-1669.
26. Sakurai, Y., K. Tsukamoto, and T. Sawai. 1991. Nucleotide sequence and characterization of a carbenicillin-hydrolyzing penicillinase gene from Proteus mirabilis. J. Bacteriol. 173:7038-7041.
27. Sanschagrin, F., N. Bejaoui, and R. C. Levesque. 1998. Structure of CARB-4 and AER-1 carbenicillin-hydrolyzing β-lactamases. Antimicrob. Agents Chemother. 42:1966-1972.
28. Stokes, H. W., D. B. O'Gorman, G. D. Recchia, M. Parsekhian, and R. M. Hall. 1997. Structure and function of 59-base element recombination sites associated with mobile gene cassettes. Mol. Microbiol. 26:731-745.
29. Thungapathra, M., Amita, K. K. Sinha, S. R. Chaudhuri, P. Garg, T. Ramamurthy, G. B. Nair, and A. Ghosh. 2002. Occurrence of antibiotic resistance gene cassettes aac(6′)-Ib, dfrA5, dfrA12, and ereA2 in class I integrons in non-O1, non-O139 Vibrio cholerae strains in India. Antimicrob. Agents Chemother. 46:2948-2955.