Induction of acute graft-versus-host disease by T cells that do not respond to in vitro alloantigen stimulation

British Journal of Haematology

Volumn 126, Issue 6, 2004, Pages 828-836

  New, Jen Yan ^a   Chan, Soh Ha ^a   Yap, Eu Hian ^a   Hu, Huaizhong ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Alloreactive response; Cellular proliferation; Graft versus host disease; T lymphocytes; Transplant tolerance

Indexed keywords

ALLOANTIGEN; CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER;

ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL PRACTICE; CONTROLLED STUDY; GRAFT VERSUS HOST REACTION; IMMUNOSTIMULATION; LYMPH NODE CELL; LYMPHOCYTE PROLIFERATION; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; SPLEEN CELL; T LYMPHOCYTE;

ACUTE DISEASE; ADOPTIVE TRANSFER; ANIMALS; CELL DIVISION; GRAFT VS HOST DISEASE; ISOANTIGENS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, SCID; T-LYMPHOCYTE SUBSETS;

EID: 4644269695     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2004.05131.x     Document Type: Article

References (44)

1. Amrolia, P.J., Muccioli-Casadei, G., Yvon, E., Huls, H., Sili, U., Wieder, E.D., Bollard, C., Heslop, H.E., Molldrem, J. J., Rooney, C.M. & Brenner, M.K. (2003) Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses. Blood, 102, 2292-2299.
2. Angulo, R. & Fulcher, D.A. (1998) Measurement of Candida-specific blastogenesis: comparison of carboxyfluorescein succinimidyl ester labelling of T cells, thymidine incorporation, and CD69 expression. Cytometry, 34, 143-151.
3. Bell, E.B., Sparshott, S.M., Drayson, M.T. & Ford, W.L. (1987) The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells. Journal of Immunology, 139, 1379-1384.
4. Bishop, D.K. & Orosz, C.G. (1989) Limiting dilution analysis for alloreactive, TCGF-secretory T cells: two related LDA methods that discriminate between unstimulated precursor T cells and in vivo-alloactivated T cells. Transplantation, 47, 671-677.
5. Cavazzana-Calvo, M., Stephan, J.L., Sarnacki, S., Chevret, S., Fromont, C., de Coene, C., Le Deist, F., Guy-Grand, D. & Fischer, A. (1994) Attenuation of graft-versus-host disease and graft rejection by ex vivo immunotoxin elimination of alloreactive T cells in an H-2 haplotype disparate mouse combination. Blood, 83, 288-298.
6. Chen, B.J., Cui, X., Liu, C. & Chao, N.J. (2002) Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process. Blood, 99, 3083-3088.
7. Falkenburg, J.H.F., van de Corput, L., Marijt, E.W.A. & Willemze, R. (2003) Minor histocompatibility antigens in human stem cell transplantation. Experimental Hematology, 31, 743-751.
8. Ford, W.L., Simmonds, S.J. & Atkins, R.C. (1975) Early cellular events in a systemic graft-vs.-host reaction. II. Autoradiographic estimates of the frequency of donor lymphocytes which respond to each Ag-B-determined antigenic complex. Journal of Experimental Medicine, 141, 681-696.
9. Fussell, S.T., Donnellan, M., Cooley, M.A. & Farrell, C. (1994) Cytotoxic T lymphocyte precursor frequency does not correlate with either the incidence or severity of graft-versus-host disease after matched unrelated donor bone marrow transplantation. Transplantation, 57, 673-676.
10. Garderet, L., Snell, V., Przepiorka, D., Schenk, T., Lu, J.G., Marini, F., Gluckman, E., Andreeff, M. & Champlin, R.E. (1999) Effective depletion of alloreactive lymphocytes from peripheral blood mononuclear cell preparations. Transplantation, 67, 124-130.
11. Goulmy, E., Stijnen, T., Groenewoud, A.F., Persijn, G.G., Blokland, E., Pool, J., Paul, L.C. & van Rood, J.J. (1989) Renal transplant patients monitored by the cell-mediated lympholysis assay. Evaluation of its clinical value. Transplantation, 48, 559-563.
12. Hall, B.M. (1991) Cells mediating allograft rejection. Transplantation, 51, 1141-1151.
13. Harris, D.T., Sakiestewa, D., Lyons, C., Kreitman, R.J. & Pastan, I. (1999) Prevention of graft-versus-host disease (GVHD) by elimination of recipient-reactive donor T cells with recombinant toxins that target the interleukin 2 (IL-2) receptor. Bone Marrow Transplantation, 23, 137-144.
14. Hayry, P. (1989) Mechanisms of rejection. Current Opinions in Immunology, 1, 1230-1235.
15. Hu, U.Z., Robertus, M., de Jonge, N., Gmelig-Meyling, F.H., van der Meulen, A., Schuurman, H.J., Doornewaard, H., van Prooijen, H.C. & de Weger, R.A. (1994) Reduction of donor-specific cytotoxic T lymphocyte precursors in peripheral blood of allografted heart recipients. Transplantation, 58, 1263-1268.
16. Hu, H.Z., Li, G.L., Lim, Y.K., Chan, S.H. & Yap, E.H. (1999) Kinetics of interferon-γ secretion and its regulatory factors in the early phase of acute graft-versus-host disease. Immunology, 98, 379-385.
17. Hu, H.Z., Dong, Y., Feng, P., Fechner, J., Hamawy, M. & Knechtle, S.J. (2003) Effect of immunosuppressants on T-cell subsets observed in vivo using carboxy-fluorescein diacetate succinimidyl ester labeling. Transplantation, 75, 1075-1077.
18. Hu, H.Z., Tang, K.F., Chua, Y.N., Lu, J.H., Feng, P., Chew, C.T. & Chan, S.H. (2004) Expression of interleukin-18 by nasopharyngeal carcinoma cells: a factor that possibly initiates the massive leukocyte infiltration. Human Pathology, 35, 722-728.
19. Jones, G. (1973) The number of reactive cells in mouse lymphocyte cultures stimulated by PHA, Con A or histocompatibility antigen. Journal of immunology, 111, 914-920.
20. Koh, M.B., Prentice, H.G., Corbo, M., Morgan, M., Cotter, F.E. & Lowdell, M.W. (2002) Alloantigen-specific T-cell depletion in a major histocompatibility complex fully mismatched murine model provides effective graft-versus-host disease prophylaxis in the presence of lymphoid engraftment. British Journal of Haematology, 118, 108-116.
21. Li, B., New, J.Y., Yap, E.H., Lu, J., Chan, S.H. & Hu, H.Z. (2001a) Blocking L-selectin and α4-integrin changes donor cell homing pattern and ameliorates murine acute graft-versus-host disease. European Journal of immunology, 31, 617-624.
22. Li, X.C., Demirci, G., Ferrari-Lacraz, S., Groves, C., Coyle, A., Malek, T.R. & Strom, T.B. (2001b) IL-15 and IL-2: a matter of life and death for T cells in vivo. Nature Medicine, 7, 114-118.
23. Li, B., New, J.Y., Tay, Y.K., Goh, E., Yap, E.H., Chan, S.H., & Hu, H.Z. (2004) Delaying acute graft versus host disease in mouse bone marrow transplantation by treating donor cells with antibodies directed at L-selectin and α4-integrin prior to infusion. Scandinavian Journal of Immunology, 59, 464-468.
24. Lyons, A.B. & Parish, C.R. (1994) Determination of lymphocyte division by flow cytometry. Journal of Immunological Methods, 171, 131-137.
25. Matesic, D., Lehmann, P.V. & Heeger, P.S. (1998) High-resolution characterization of cytokine-producing alloreactivity in naive and allograft-primed mice. Transplantation, 65, 906-914.
26. Maury, S., Salomon, B., Klatzmann, D. & Cohen, J.L. (2001) Division rate and phenotypic differences discriminate alloreactive and nonalloreactive T cells transferred in lethally irradiated mice. Blood, 98, 3156-3158.
27. van der Meer, A., Allebes, W.A., Voorter, C.E., van den Berg-Loonen, E.M., Schattenberg, A.V., de Witte, T.J. & Joosten, I. (1998) Helper and cytotoxic T cell precursor frequencies are not predictive for development of acute graft-versus-host disease after partially T cell-depleted HLA-identical sibling BMT. Bone Marrow Transplantation, 22, 1049-1055.
28. Mickelson, E.M., Bartsch, G.E., Hansen, J.A. & Dupont, B. (1993) The MLC assay as a test for HLA-D region compatibility between patients and unrelated donors: results of a national marrow donor program involving multiple centers. Tissue Antigens, 42, 465-472.
29. Mickelson, E.M., Longton, G., Anasetti, C., Petersdorf, E., Martin, P., Guthrie, L.A. & Hansen, J.A. (1996) Evaluation of the mixed lymphocyte culture (MLC) assay as a method for selecting unrelated donors for marrow transplantation. Tissue Antigens, 47, 27-36.
30. Najafian, N., Salama, A.D., Fedoseyeva, E.V., Benichou, G. & Sayegh, M.H. (2002) Enzyme-linked immunosorbent spot assay analysis of peripheral blood lymphocyte reactivity to donor HLA-DR peptides: potential novel assay for prediction of outcomes for renal transplant recipients. Journal of the American Society of Nephrology, 13, 252-259.
31. New, J.Y., Li, B., Koh, W.P., Ng, H.K., Tan, S.Y., Yap, E.H., Chan, S.H. & Hu, H.Z. (2002) T cell infiltration and chemokine expression: Relevance to the disease localization in murine graft-versus-host disease. Bone Marrow Transplantation, 29, 979-986.
32. Nielsen, H.E. (1978) Quantitative aspects of in vitro lymphocyte culture. Danish Medical Bulletin, 25, 93-106.
33. Nikolic, B., Lee, S., Bronson, R.T., Grusby, M.J. & Sykes, M. (2000) Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets. Journal of Clinical Investigation, 105, 1289-1298.
34. Pei, J., Martin, P.J., Longton, G., Masewicz, S., Mickelson, E., Petersdorf, E., Anasetti, C. & Hansen, J. (1997) Evaluation of pretransplant donor anti-recipient cytotoxic and helper T lymphocyte responses as correlates of acute graft-vs.-host disease and survival after unrelated marrow transplantation. Biology of Blood and Marrow Transplantation, 3, 142-149.
35. Reinsmoen, N.L. (2002) Cellular methods used to evaluate the immune response in transplantation. Tissue Antigens, 59, 241-250.
36. Rocha, B., Dautigny, N. & Pereira, P. (1989) Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo. European Journal of Immunology, 19, 905-911.
37. Segall, M., Noreen, H., Edwins, L., Haake, R., Shu, X.O. & Kersey, J. (1996) Lack of correlation of MLC reactivity with acute graft-versus-host disease and mortality in unrelated donor bone marrow transplantation. Human Immunology, 49, 49-55.
38. Skinner, M.A. & Marbrook, J. (1976) An estimation of the frequency of precursor cells which generate cytotoxic lymphocytes. Journal of Experimental Medicine, 143, 1562-1567.
39. Steinmann, J., Kaden, J., May, G., Schroder, K., Herwartz, C. & Muller-Ruchholtz, W. (1994) Failure of in vitro T-cell assays to predict clinical outcome after human kidney transplantation. Journal of Clinical Lab Analysis, 8, 157-162.
40. Suchin, E.J., Langmuir, P.B., Palmer, E., Sayegh, M.H., Wells, A.D. & Turka, L.A. (2001) Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question. Journal of Immunology, 166, 973-981.
41. Tang, K.F., Tan, S.Y., Chan, S.H., Chong, S.M., Loh, K.S., Tan, L.K.S. & Hu, H.Z. (2001) A distinct expression of C-C chemokines by macrophages in nasopharyngeal carcinoma: implication for the intense tumor infiltration by T lymphocytes and macrophages. Human Pathology, 32, 42-49.
42. Tary-Lehmann, M., Hricik, D.E., Justice, A.C., Potter, N.S. & Heeger, P.S. (1998) Enzyme-linked immunosorbent assay spot detection of interferon-gamma and interleukin 5-producing cells as a predictive marker for renal allograft failure. Transplantation, 66, 219-224.
43. Wilson, D.B. & Nowell, P.C. (1968) Quantitative studies on the mixed lymphocyte interaction in rats III. Kinetics of the response. Journal of Experimental Medicine, 129, 1157-1181.
44. Wilson, D.B. & Nowell, P.C. (1970) Quantitative studies on the mixed lymphocyte interaction in rats IV. Immunologic potentiality of the responding cells. Journal of Experimental Medicine, 131, 391-407.