Clinical and microbiological effects of topical subgingival application of hyaluronic acid gel adjunctive to scaling and root planing in the treatment of chronic periodontitis

Journal of Periodontology

Volumn 75, Issue 8, 2004, Pages 1114-1118

  Xu, Yi ^a   Hofling K ^b   Fimmers, R ^b   Frentzen, M ^b   Jervoe Storm P M ^b  

^a SICHUAN UNIVERSITY   (China)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Adjunctive therapy; Hyaluronic acid therapeutic use; Periodontitis drug therapy; Periodontitis therapy; Planing; Scaling

Indexed keywords

GENGIGEL; HYALURONIC ACID;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ADULT; ARTICLE; BACTERIUM DETECTION; CHRONIC DISEASE; CLINICAL ARTICLE; CLINICAL OBSERVATION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG USE; FEMALE; FLOW RATE; FLUID FLOW; GEL; GINGIVA; GINGIVA BLEEDING; GRAM NEGATIVE BACTERIUM; HUMAN; HUMAN TISSUE; INTERMETHOD COMPARISON; MALE; NONHUMAN; PATIENT MONITORING; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; PREVENTIVE DENTISTRY; PREVOTELLA INTERMEDIA; TANNERELLA FORSYTHENSIS; TOOTH PLAQUE; TREATMENT OUTCOME; TREPONEMA DENTICOLA;

ADMINISTRATION, TOPICAL; ANALYSIS OF VARIANCE; ANTI-BACTERIAL AGENTS; BACTERIA, ANAEROBIC; CHEMOTHERAPY, ADJUVANT; CHRONIC DISEASE; DENTAL SCALING; FEMALE; GELS; GINGIVAL CREVICULAR FLUID; GRAM-NEGATIVE BACTERIA; HUMANS; HYALURONIC ACID; MALE; MIDDLE AGED; PERIODONTAL INDEX; PERIODONTITIS; SECRETORY RATE;

EID: 4644262177     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2004.75.8.1114     Document Type: Article

References (19)

1. Bollen CML, Quirynen M. Microbiological response to mechanical treatment in combination with adjunctive therapy. A review of the literature. J Periodontol 1996; 67:1143-1158.
2. Cugini MA, Haffajee AD, Smith C, Kent RL Jr, Socransky SS. The effect of scaling and root planing on the clinical and microbiological parameter of periodontal diseases: 12-month results. J Clin Periodontol 2000;27:30-36.
3. Quirynen M, Teughels W, De Soete M, Van Steenberghe D. Topical antiseptics and antibiotics in the initial therapy of chronic adult periodontitis: Microbiological aspects. Periodontol 2000 2002;28:72-90.
4. Slots J. The search for effective, safe and affordable periodontal therapy. Periodontol 2000 2002;28:9-11.
5. Slots J, Ting M. Systemic antibiotics in the treatment of periodontal disease. Periodontol 2000 2002;28:106-176.
6. Roberts MC. Antibiotic toxicity, interactions and resistance development. Periodontol 2000 2002;28:280-297.
7. Oksala O, Salvo T, Tammi R, et al. Expression of proteoglycans and hyaluronan during wound healing. J Histochem Cytochem 1995;43:125-135.
8. Stamenkovic I, Aruffo A. Hyaluronic acid receptors. Meth Enzymol 1994;245:195-216.
9. Tammi R, Tammi M, Häkkinin L, Larjava H. Histochemical localization of hyaluronate in human oral epithelium using a specific hyaluronate-binding probe. Arch Oral Biol 1990;35:219-223.
10. Giannobile WV, Riviere GR, Gorski JP, Tira DE, Cobb CM. Glycosaminoglycans and periodontal disease: Analysis of GCF by safranin O. J Periodontol 1993;64:186-190.
11. Pirnaza P, Wolinsky L, Nachnani S, Haake S, Pilloni A, Bernhard GW. Bacteriostatic effects of hyaluronic acid. J Periodontol 1999;70:370-374.
12. Pagnacco A, Vangelisti R, Erra C, Poma A. Double-blind clinical trial versus placebo of a new sodium-hyaluronate-based gingival gel (in Italian). Attualità Terapeutica Interpazzionale 1997; 15:1-7.
13. Jentsch H, Pomowski R, Kundt G, Göcke, R. Treatment of gingivitis with hyaluronan. J Clin Periodontol 2003;30:159-164.
14. Eick S, Pfister W. Comparison of microbial cultivation and a commercial nucleic acid based method for detection of periodontopathogenic species in subgingival plaque samples. J Clin Periodontol 2002;29:638-644.
15. Haffajee AD, Cugini MA, Dibart S, Smith C, Kent RL Jr, Socransky SS. The effect of SRP on the clinical and microbiological parameters of periodontal diseases. J Clin Periodontol 1997;24:324-334.
16. Hung HC, Douglass CW. Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss. J Clin Periodontol 2002;29:975-986.
17. Flötra LS, Gjermo P, Rölla G, Waerhaug J. A 4-month study on the effect of chlorhexidine mouthwashes on 50 soldiers. Scand J Dent Res 1972;80:10-17.
18. Darby IB, Mooney J, Kinane DF. Changes in subgingival microflora and humoral immune response following periodontal therapy. J Clin Periodontol 2001;28:796-805
19. Haffajee AD, Socransky SS. Microbial etiological agents of destructive periodontal diseases. Periodontol 2000 1994;5:78-111.