Finding value in in silico biology

Drug Discovery Today: BIOSILICO

Volumn 1, Issue 1, 2003, Pages 18-22

  Bangs, Alex L ^a   Paterson, Thomas S ^a  

^a Entelos Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; INTERLEUKIN 5 ANTIBODY;

ASTHMA; CLINICAL TRIAL; COMPUTER MODEL; COMPUTER SIMULATION; DRUG INDUSTRY; DRUG TARGETING; GENE EXPRESSION; HUMAN; MEDICAL DECISION MAKING; MEDICAL INFORMATION; MEDICAL RESEARCH; MEDICAL TECHNOLOGY; MOLECULAR BIOLOGY; OUTCOMES RESEARCH; PHARMACOGENOMICS; PIPELINE; REVIEW; SCIENCE; VALIDATION PROCESS;

EID: 4644327461     PISSN: 17418364     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1478-5382(03)02218-2     Document Type: Review

References (11)

1. Ho, R.L. (2000) Biosystems modeling for in silico target validation: challenges to implementation. Emerg. Ther. Targets 4, 699-714
2. Tufts Center for Study of Drug Development, Outlook 2002, pg. 1, Boston, MA, USA. http://csdd.tufts.edu/InfoServices/OutlookReports.asp
3. Lehman Brothers and McKinsey & Company Report (2001) The Fruits of Genomics, p34
4. Forst, C.V. (2002) Using a systems biological approach to develop novel therapeutics. Pharmacogenomics 3, 12-14
5. Timchalk, C. et al. (2001) The virtual body workshop: current and future application of human biology models in environmental health research. Environ. Health Perspect. 109, 421-423
6. Su, F. (1998) Virtual human serves as platform for range of responses. OE Reports 169, http://www.spie.org/web/oer/january/jan98/vrhuman.html
7. Paterson, T. (2002) Applying simulation technology to the life sciences. In Seventh Annual Symposium on Frontiers of Engineering, pp. 85-90, Academic Press
8. Lewis, A.K. et al. (2001) The roles of cells and mediators in a computer model of chronic asthma. Int. Arch. Allergy Immunol. 124, 282-286
9. Leckie, M.J. et al. (2000) Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 356, 2144-2148
10. Wallwork, C.J. (2002) Using the Entelos Diabetes PhysioLab to improve clinical trial design and data analysis. Presented at Beyond Genome: In Silico Biology, San Diego, CA, USA, http://www.beyondgenome.com/isb2002.asp
11. Li, H. (2002) Application of in silico biology technology in clinical development and its challenges. Presented at Beyond Genome: In Silico Biology, San Diego, CA, USA, http://www.beyondgenome.com/isb2002.asp