Deletion of the CCK2 receptor gene reduces mechanical sensitivity and abolishes the development of hyperalgesia in mononeuropathic mice

European Journal of Neuroscience

Volumn 20, Issue 6, 2004, Pages 1577-1586

  Kurrikoff, Kaido ^a   Kõks, Sulev ^a   Matsui, Toshimitsu ^b   Bourin, Michel ^c   Arend, Andres ^a   Aunapuu, Marina ^a   Vasar, Eero ^a  

^a UNIVERSITY OF TARTU   (Estonia)

^b KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITÉ DE NANTES   (France)

Author keywords

CCK; CCK2 knockout mice; Gene expression; Mechanical sensitivity; Neuropathic pain; Opioid

Indexed keywords

1 (2,3 DIHYDRO 1 METHYL 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL) 3 (3 METHYLPHENYL)UREA; CHOLECYSTOKININ B RECEPTOR; DELTA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR; NALOXONE; OPIATE RECEPTOR; PROOPIOMELANOCORTIN; RECEPTOR BLOCKING AGENT; BENZODIAZEPINE DERIVATIVE; CARBANILAMIDE DERIVATIVE; CHOLECYSTOKININ RECEPTOR; DYNORPHIN; ENKEPHALIN; MESSENGER RNA; NARCOTIC ANTAGONIST; PROENKEPHALIN; PROTEIN PRECURSOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; GENE DELETION; GENE EXPRESSION; HYPERALGESIA; KNOCKOUT GENE; MECHANICAL STIMULATION; MOUSE; NEUROPATHIC PAIN; NEUROPATHOLOGY; NONHUMAN; PAIN THRESHOLD; PHYSICAL SENSITIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECEPTOR GENE; RECEPTOR UPREGULATION; WILD TYPE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CLASSIFICATION; COMPARATIVE STUDY; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; INFLAMMATION; LIGATION; MALE; METABOLISM; METHODOLOGY; MOUSE MUTANT; PAIN ASSESSMENT; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCIATIC NEUROPATHY; TIME;

ANIMALS; BENZODIAZEPINONES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DYNORPHINS; ENKEPHALINS; GENE EXPRESSION; HYPERALGESIA; INFLAMMATION; LIGATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NALOXONE; NARCOTIC ANTAGONISTS; PAIN MEASUREMENT; PAIN THRESHOLD; PHENYLUREA COMPOUNDS; PRO-OPIOMELANOCORTIN; PROTEIN PRECURSORS; RECEPTOR, CHOLECYSTOKININ B; RECEPTORS, CHOLECYSTOKININ; RECEPTORS, OPIOID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SCIATIC NEUROPATHY; TIME FACTORS;

EID: 4644249150     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2004.03619.x     Document Type: Article

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