Ethanol excitation of dopaminergic ventral tegmental area neurons is blocked by quinidine

Journal of Pharmacology and Experimental Therapeutics

Volumn 306, Issue 2, 2003, Pages 437-446

  Appel, Sarah B ^a,b   Liu, Zhaoping ^a   McElvain, Maureen A ^a   Brodie, Mark S ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (N ETHYL N PHENYLAMINO) 1,2 DIMETHYL 6 (METHYLAMINO)PYRIMIDINIUM CHLORIDE; ALCOHOL; BARIUM; CALCIUM; CESIUM; G PROTEIN COUPLED RECEPTOR; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM ION; QUINIDINE; TETRYLAMMONIUM;

ACTION POTENTIAL; AFTERHYPERPOLARIZATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; MALE; NERVE CELL STIMULATION; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; REINFORCEMENT; SINGLE UNIT ACTIVITY; VENTRAL TEGMENTUM;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; BARIUM; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CESIUM; DOPAMINE; DRUG INTERACTIONS; ETHANOL; ION CHANNELS; MALE; NEURONS; PYRIMIDINES; QUINIDINE; RATS; RATS, INBRED F344; RECEPTORS, DOPAMINE; TETRAETHYLAMMONIUM; VENTRAL TEGMENTAL AREA;

EID: 0037961005     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.050963     Document Type: Article

References (40)

1. Brodie MS and Appel SB (1998) The effects of ethanol on dopaminergic neurons of the ventral tegmental area studied with intracellular recording in brain slices. Alcoholism Clin Exp Res 22:236-244.
2. Brodie MS, Liu JP, Yu B, and Appel SB (2000) Ethanol decreases a sustained potassium current in rat dopaminergic neurons of the ventral tegmental area. Soc Neurosci Abstr 26:785.
3. Brodie MS, McElvain MA, Bunney EB, and Appel SB (1999a) Pharmacological reduction of small conductance calcium-activated potassium current (SK) potentiates the excitatory effect of ethanol on ventral tegmental area dopamine neurons. J Pharmacol Exp Ther 290:325-333.
4. Brodie MS, Pesold C, and Appel SB (1999b) Ethanol directly excites dopaminergic ventral tegmental area reward neurons. Alcoholism Clin Exp Res 23:1848-1852.
5. Brodie MS, Shefner SA, and Dunwiddie TV (1990) Ethanol increases the firing rate of dopamine neurons of the rat ventral tegmental area in vitro. Brain Res 508:65-69.
6. + channels. Ann NY Acad Sci 868:233-285.
7. Di Chiara G and Imperato A (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic dopamine system of freely moving rats. Proc Natl Acad Sci USA 85:5274-5278.
8. Ducouret P (1976) The effect of quinidine on membrane electrical activity in frog auricular fibres studied by current and voltage clamp. Br J Pharmacol 57:163-184.
9. Gessa GL, Muntoni F, Collu M, Vargiu L, and Mereu G (1985) Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area. Brain Res 348:201-203.
10. + channels, types Kv1.1, 1.2, 1.3, 1.5 and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol 45:1227-1234.
11. Haggard HW, Greenberg LA, and Rakieten N (1940) Studies on the absorption, distribution and elimination of alcohol. VI. The principles governing the concentration of alcohol in the blood and the concentration causing respiratory failure. J Pharmacol Exp Ther 69:252-265.
12. Harris NC and Constanti A (1995) Mechanism of block by ZD 7288 of the hyperpolarization-activated inward rectifying current in guinea pig substantia nigra neurons in vitro. J Neurophysiol 74:2366-2378.
13. Hermann A and Gorrean AL (1984) Action of quinidine on ionic currents of molluscan pacemaker neurons. J Gen Physiol 83:919-940.
14. Kang J, Chen XL, Wang L, and Rampe D (2001) Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK and HERG. J Pharmacol Exp Ther 299:290-296.
15. + channel mRNAs are differentially expressed in the adult rat brain. J Neurosci 16:3559-3570.
16. Kim K-M, Nakajima Y, and Nakajima S (1995) G protein-coupled inward rectifier modulated by dopamine agonists in cultured substantia nigra neurons. Neuroscience 69:1145-1158.
17. + channels. Nat Neurosci 2:1091-1097.
18. Lacey MG, Mercuri NB, and North RA (1987) Dopamine acts on D2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta. J Physiol (Lond) 392:397-416.
19. Lacey MG, Mercuri NB, and North RA (1989) Two cell types in rat substantia nigra zona compacta distinguished by membrane properties and the actions of dopamine and opioids. J Neurosci 9:1233-1241.
20. + channels. J Biol Chem 270:28660-28667.
21. Lewohl JM, Wilson WR, Mayfield RD, Brozowski SJ, Morrisett RA, and Harris RA (1999) G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action. Nat Neurosci 2:1084-1090.
22. Liu ZP, Appel SB, and Brodie MS (1999) Serotonin reduces time-dependent inward rectification (Ih) in ventral tegmental area dopamine neurons. Soc Neurosci Abstr 25:439.
23. Majchrowicz E and Hunt WA (1976) Temporal relationship of the induction of tolerance and physical dependence after continuous intoxication with maximum tolerable doses of ethanol in rats. Psychopharmacology 50:107-112.
24. h in rat midbrain dopaminergic neurons. Eur J Neurosci 7:462-469.
25. Mueller AL and Brodie MS (1989) Intracellular recording from putative dopamine-containing neurons in the ventral tegmental area of Tsai in a brain slice preparation. J Neurosci Methods 28:15-22.
26. Neuhoff H, Neu A, Liss B, and Roeper J (2002) I(h) channels contribute to the different functional properties of identified dopaminergic subpopulations in the midbrain. J Neurosci 22:1290-1302.
27. Oades RD and Halliday GM (1987) Ventral tegmental (A10) system: neurobiology. 1. Anatomy and connectivity. Brain Res Rev 12:117-165.
28. + channels. Proc Natl Acad Sci USA 93:9270-9275.
29. Rettig J, Wunder F, Stocker M, Lichtinghagen R, Mastiaux F, Beckh S, Kues W, Pedarzani P, Schroter KH, and Ruppersberg JP (1992) Characterization of a Shaw-related potassium channel family in rat brain. EMBO J 11:2473-2486.
30. Rodd-Henricks ZA, McKinzie DL, Crile RS, Murphy JM, and McBride WJ (2000) Regional heterogeneity for the intracranial self-administration of ethanol within the ventral tegmental area of female Wistar rats. Psychopharmacology (Berl) 149:217-224.
31. Samson HH, Tolliver GA, and Schwarz-Stevens K (1990) Oral ethanol self-administration: a behavioral pharmacological approach to CNS control mechanisms. Alcohol 7:187-191.
32. Schonherr R, Gessner G, Lober K, and Heinemann SH (2002) Functional distinction of human EAG1 and EAG2 potassium channels. FEBS Lett 514:204-208.
33. + conductance. Exp Brain Res 86:141-150.
34. Silva NL, Pechura CM, and Barker JL (1990) Postnatal rat nigrostriatal dopaminergic neurons exhibit five types of potassium conductances. J Neurophysiol 64:262-272.
35. Singh A and Singh S (1999) Unmasking of a novel potassium current in Drosophila by a mutation and drugs. J Neurosci 19:6838-6843.
36. Snyders DJ, Knoth KM, Roberds SL, and Tamkun MM (1992) Time-, voltage- and state-dependent block by quinidine of a cloned human cardiac potassium channel. Mol Pharmacol 41:322-330.
37. Weiss F, Lorang MT, Bloom FE, and Koob GF (1993) Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants. J Pharmacol Exp Ther 267:250-258.
38. Werner P, Hussy N, Buell G, Jones KA, and North RA (1996) D2, D3 and D4 dopamine receptors couple to G protein-regulated potassium channels in Xenopus oocytes. Mol Pharmacol 49:656-661.
39. + channel. Role of S6 in antiarrhythmic drug binding. Circ Res 78:1105-1114.
40. Yeola SW and Snyders DJ (1997) Electrophysiological and pharmacological correspondence between Kv4.2 current and rat cardiac transient outward current. Cardiovasc Res 33:540-547.